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• W4387036982 abstract "Coordination of mitotic exit with chromosome segregation is key for successful mitosis. Mitotic exit in budding yeast is executed by the mitotic exit network (MEN), which is negatively regulated by the spindle position checkpoint (SPOC). SPOC kinase Kin4 is crucial for SPOC activation in response to spindle positioning defects. Here, we report that the lysosomal signalling lipid phosphatidylinositol-3,5-bisphosphate (PI3,5P 2 ) has an unanticipated role in the timely execution of mitotic exit. We show that the lack of PI3,5P 2 causes a delay in mitotic exit, whereas elevated levels of PI3,5P 2 accelerates mitotic exit in mitotic exit defective cells. Our data indicate that PI3,5P 2 promotes mitotic exit in part through impairment of Kin4. This process is largely dependent on the known PI3,5P 2 effector protein Atg18. Our work thus uncovers a novel link between PI3,5P 2 and mitotic exit." @default.
• W4387036982 created "2023-09-27" @default.
• W4387036982 creator A5020450484 @default.
• W4387036982 creator A5062430824 @default.
• W4387036982 creator A5092940276 @default.
• W4387036982 creator A5092940277 @default.
• W4387036982 date "2023-09-01" @default.
• W4387036982 modified "2023-10-11" @default.
• W4387036982 title "The signalling lipid PI3,5P ₂ is essential for timely mitotic exit" @default.
• W4387036982 cites W116093739 @default.
• W4387036982 cites W1495616591 @default.
• W4387036982 cites W1497947649 @default.
• W4387036982 cites W1542805579 @default.
• W4387036982 cites W1876069258 @default.
• W4387036982 cites W1897417227 @default.
• W4387036982 cites W1963318786 @default.
• W4387036982 cites W1980057048 @default.
• W4387036982 cites W1987767376 @default.
• W4387036982 cites W1993828912 @default.
• W4387036982 cites W1995966088 @default.
• W4387036982 cites W2001985415 @default.
• W4387036982 cites W2003391646 @default.
• W4387036982 cites W2003416728 @default.
• W4387036982 cites W2008187459 @default.
• W4387036982 cites W2018046158 @default.
• W4387036982 cites W2018697695 @default.
• W4387036982 cites W2029819246 @default.
• W4387036982 cites W2031198628 @default.
• W4387036982 cites W2034320996 @default.
• W4387036982 cites W2036806208 @default.
• W4387036982 cites W2039713740 @default.
• W4387036982 cites W2040896118 @default.
• W4387036982 cites W2044718215 @default.
• W4387036982 cites W2045714699 @default.
• W4387036982 cites W2053071160 @default.
• W4387036982 cites W2057975768 @default.
• W4387036982 cites W2063448502 @default.
• W4387036982 cites W2065105328 @default.
• W4387036982 cites W2066298493 @default.
• W4387036982 cites W2066841738 @default.
• W4387036982 cites W2068728659 @default.
• W4387036982 cites W2069423909 @default.
• W4387036982 cites W2069628410 @default.
• W4387036982 cites W2072107269 @default.
• W4387036982 cites W2072317853 @default.
• W4387036982 cites W2073057670 @default.
• W4387036982 cites W2075171680 @default.
• W4387036982 cites W2078547053 @default.
• W4387036982 cites W2079116237 @default.
• W4387036982 cites W2080247794 @default.
• W4387036982 cites W2082692750 @default.
• W4387036982 cites W2083294698 @default.
• W4387036982 cites W2085333060 @default.
• W4387036982 cites W2085850073 @default.
• W4387036982 cites W2086280671 @default.
• W4387036982 cites W2088609845 @default.
• W4387036982 cites W2093365370 @default.
• W4387036982 cites W2097497257 @default.
• W4387036982 cites W2098013039 @default.
• W4387036982 cites W2100025072 @default.
• W4387036982 cites W2100850659 @default.
• W4387036982 cites W2101717366 @default.
• W4387036982 cites W2106754534 @default.
• W4387036982 cites W2106959576 @default.
• W4387036982 cites W2109595760 @default.
• W4387036982 cites W2112605694 @default.
• W4387036982 cites W2114268618 @default.
• W4387036982 cites W2118612600 @default.
• W4387036982 cites W2119889328 @default.
• W4387036982 cites W2120945691 @default.
• W4387036982 cites W2126659352 @default.
• W4387036982 cites W2127449899 @default.
• W4387036982 cites W2131188751 @default.
• W4387036982 cites W2131266367 @default.
• W4387036982 cites W2139139999 @default.
• W4387036982 cites W2140758058 @default.
• W4387036982 cites W2151650074 @default.
• W4387036982 cites W2151907317 @default.
• W4387036982 cites W2152231771 @default.
• W4387036982 cites W2154019163 @default.
• W4387036982 cites W2154046032 @default.
• W4387036982 cites W2156128107 @default.
• W4387036982 cites W2156748406 @default.
• W4387036982 cites W2156989591 @default.
• W4387036982 cites W2158334311 @default.
• W4387036982 cites W2159007909 @default.
• W4387036982 cites W2162126864 @default.
• W4387036982 cites W2163277462 @default.
• W4387036982 cites W2164918307 @default.
• W4387036982 cites W2165079759 @default.
• W4387036982 cites W2170445185 @default.
• W4387036982 cites W2170783561 @default.
• W4387036982 cites W2171302195 @default.
• W4387036982 cites W2171837066 @default.
• W4387036982 cites W2276772012 @default.
• W4387036982 cites W2278179716 @default.
• W4387036982 cites W2281088055 @default.
• W4387036982 cites W2371923445 @default.
• W4387036982 cites W2410463335 @default.
• W4387036982 cites W2472093118 @default.

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