FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387037310> ?p ?o ?g. }

• W4387037310 endingPage "S10" @default.
• W4387037310 startingPage "S10" @default.
• W4387037310 abstract "Introduction: The development of overt hepatic encephalopathy (oHE) is a dreaded complication in patients with liver cirrhosis. Additionally, advanced liver disease is associated with increased risk of rehospitalization and mortality. The evaluation and comparison of prognostic values of different minimal hepatic encephalopathy (mHE) tests regarding these outcomes is an unmet need. We evaluated 6 widely used mHE tests regarding their predictive value for oHE, rehospitalization and death. Patients and Methods: In this prospective study, we recruited 132 patients with liver cirrhosis between August 2021 and April 2022. All patients performed a mHE assessment consisting of PSE-Syndrome Test (PHES), Animal Naming Test (ANT), Critical Flicker Frequency (CFF), Inhibitory Control Test (ICT), EncephalApp (Stroop) and Continuous Reaction Time Test (CRT). Patients were monitored for 365 days regarding development of oHE, rehospitalization and death. We performed competing risk analyses (treating death/liver transplantation as competitor) for oHE and rehospitalization and cox regression for death. Results: At baseline, median age was 57, median MELD 12 and Child Pugh Score 7. The majority of patients were male (69%) and had an alcohol-related liver cirrhosis (52%). 30% of patients had a history of oHE and approximately half of patients had evidence of mHE. During follow up, 24 (18%) patients developed oHE, 58 (44%) were re-admitted to hospital and 32 (24%) patients died. Pathological PHES was significantly linked to oHE development in competing risk analysis during follow up, ANT only with cut-off uncorrected for age and education (Figure 1). Regarding rehospitalization, only pathological PHES results showed a significant correlation in the competing risk analysis (HR: 1.801; P=0.031). Pathological uncorrected ANT results (<23 animals) but not normalized ANT Z-scores were significantly associated with mortality in cox regression (HR: 2.397; P=0.032). Pathological results in CRT, ICT, Stroop and CFF were not significantly linked to any endpoint (oHE, rehospitalization, death). Of note, all test parameters had inferior prognostic value than the standard laboratory test results assessed in liver patients. Conclusion: This study underlines the frequency of poor outcome in patients with cirrhosis and mHE. PHES was the most reliable prognostic value among the mHE tests in predicting oHE and rehospitalization.Figure 1.: Competing risk analyses for the prediction of oHE." @default.
• W4387037310 created "2023-09-27" @default.
• W4387037310 creator A5002302125 @default.
• W4387037310 creator A5018980107 @default.
• W4387037310 creator A5035674123 @default.
• W4387037310 creator A5058530846 @default.
• W4387037310 creator A5068739017 @default.
• W4387037310 creator A5076739762 @default.
• W4387037310 creator A5089146145 @default.
• W4387037310 creator A5092940346 @default.
• W4387037310 date "2023-09-01" @default.
• W4387037310 modified "2023-09-27" @default.
• W4387037310 title "P12 Value of Six Minimal Hepatic Encephalopathy Tests in Predicting Clinical Outcome in Patients With Liver Cirrhosis" @default.
• W4387037310 doi "https://doi.org/10.14309/01.ajg.0000948332.98271.b4" @default.
• W4387037310 hasPublicationYear "2023" @default.
• W4387037310 type Work @default.
• W4387037310 citedByCount "0" @default.
• W4387037310 crossrefType "journal-article" @default.
• W4387037310 hasAuthorship W4387037310A5002302125 @default.
• W4387037310 hasAuthorship W4387037310A5018980107 @default.
• W4387037310 hasAuthorship W4387037310A5035674123 @default.
• W4387037310 hasAuthorship W4387037310A5058530846 @default.
• W4387037310 hasAuthorship W4387037310A5068739017 @default.
• W4387037310 hasAuthorship W4387037310A5076739762 @default.
• W4387037310 hasAuthorship W4387037310A5089146145 @default.
• W4387037310 hasAuthorship W4387037310A5092940346 @default.
• W4387037310 hasBestOaLocation W43870373101 @default.
• W4387037310 hasConcept C126322002 @default.
• W4387037310 hasConcept C2777075537 @default.
• W4387037310 hasConcept C2777214474 @default.
• W4387037310 hasConcept C2779250428 @default.
• W4387037310 hasConcept C2779609443 @default.
• W4387037310 hasConcept C2780325230 @default.
• W4387037310 hasConcept C2911091166 @default.
• W4387037310 hasConcept C71924100 @default.
• W4387037310 hasConcept C90924648 @default.
• W4387037310 hasConceptScore W4387037310C126322002 @default.
• W4387037310 hasConceptScore W4387037310C2777075537 @default.
• W4387037310 hasConceptScore W4387037310C2777214474 @default.
• W4387037310 hasConceptScore W4387037310C2779250428 @default.
• W4387037310 hasConceptScore W4387037310C2779609443 @default.
• W4387037310 hasConceptScore W4387037310C2780325230 @default.
• W4387037310 hasConceptScore W4387037310C2911091166 @default.
• W4387037310 hasConceptScore W4387037310C71924100 @default.
• W4387037310 hasConceptScore W4387037310C90924648 @default.
• W4387037310 hasIssue "9S" @default.
• W4387037310 hasLocation W43870373101 @default.
• W4387037310 hasOpenAccess W4387037310 @default.
• W4387037310 hasPrimaryLocation W43870373101 @default.
• W4387037310 hasRelatedWork W2009016048 @default.
• W4387037310 hasRelatedWork W2033977098 @default.
• W4387037310 hasRelatedWork W2139870153 @default.
• W4387037310 hasRelatedWork W2605146346 @default.
• W4387037310 hasRelatedWork W2768302875 @default.
• W4387037310 hasRelatedWork W2791972014 @default.
• W4387037310 hasRelatedWork W3030351087 @default.
• W4387037310 hasRelatedWork W3031456540 @default.
• W4387037310 hasRelatedWork W4327907396 @default.
• W4387037310 hasRelatedWork W4381891058 @default.
• W4387037310 hasVolume "118" @default.
• W4387037310 isParatext "false" @default.
• W4387037310 isRetracted "false" @default.
• W4387037310 workType "article" @default.