Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387041508> ?p ?o ?g. }
- W4387041508 endingPage "176083" @default.
- W4387041508 startingPage "176083" @default.
- W4387041508 abstract "Diabetic foot ulcer (DFU) is a common diabetic complication associated with disability and reduced quality of life. Available therapeutics are not sufficient to combat the spread of DFU. Here we aim to investigate the impact of alagebrium, an advanced glycation end product (AGE)-crosslink breaker, on the healing of DFU. Diabetes was induced in Wistar rats by STZ, and after four weeks, wound was induced on the foot. Alagebrium (10 mg/kg) was administered orally for 14 days, and wound size was measured every 3 days. Behavioral tests i.e., hot plate and footprint tests, were performed to assess sensory function and gait. Blood was collected to assess HbA1c, serum AGEs, MDA and NOX1. Tissue was collected to assess histological changes and expression of NF-κB, iNOS, TNF-α, VEGF and EGF. In a subsequent set of experiments with similar design, alagebrium was applied topically as a film-forming gel. Systemic alagebrium treatment accelerated the healing of diabetic wound, improved sensory functions and gait, and ameliorated histological changes. It also reduced serum levels of AGEs, MDA and NOX1, and the tissue expression of NF-κB, iNOS, TNF-α, and increased VEGF and EGF in diabetic rats. Topical alagebrium led to similar beneficial effects i.e., accelerated diabetic wound healing, improved wound histological changes, reduced expression of NF-κB and iNOS and increased VEGF. Our findings suggest repurposing of alagebrium for the management of DFU to accelerate the healing process and improve the clinical outcomes in diabetic patients." @default.
- W4387041508 created "2023-09-27" @default.
- W4387041508 creator A5009376390 @default.
- W4387041508 creator A5012343926 @default.
- W4387041508 creator A5020091276 @default.
- W4387041508 creator A5033572460 @default.
- W4387041508 creator A5053842104 @default.
- W4387041508 creator A5066672804 @default.
- W4387041508 date "2023-11-01" @default.
- W4387041508 modified "2023-10-04" @default.
- W4387041508 title "Repurposing alagebrium for diabetic foot ulcer healing: Impact on AGEs/NFκB/NOX1 signaling" @default.
- W4387041508 cites W1966234811 @default.
- W4387041508 cites W1968299608 @default.
- W4387041508 cites W2003255311 @default.
- W4387041508 cites W2017800180 @default.
- W4387041508 cites W2018610822 @default.
- W4387041508 cites W2032789741 @default.
- W4387041508 cites W2060857735 @default.
- W4387041508 cites W2082402431 @default.
- W4387041508 cites W2086204200 @default.
- W4387041508 cites W2086327676 @default.
- W4387041508 cites W2097474009 @default.
- W4387041508 cites W2120293565 @default.
- W4387041508 cites W2121269493 @default.
- W4387041508 cites W2129418175 @default.
- W4387041508 cites W2133022777 @default.
- W4387041508 cites W2136262455 @default.
- W4387041508 cites W2137880963 @default.
- W4387041508 cites W2140228577 @default.
- W4387041508 cites W2140300856 @default.
- W4387041508 cites W2140576571 @default.
- W4387041508 cites W2140915335 @default.
- W4387041508 cites W2159602704 @default.
- W4387041508 cites W2160384365 @default.
- W4387041508 cites W2172778470 @default.
- W4387041508 cites W2198148859 @default.
- W4387041508 cites W2224312260 @default.
- W4387041508 cites W2558491404 @default.
- W4387041508 cites W2588967785 @default.
- W4387041508 cites W2604493252 @default.
- W4387041508 cites W2606850324 @default.
- W4387041508 cites W2740617459 @default.
- W4387041508 cites W2767589056 @default.
- W4387041508 cites W2790819275 @default.
- W4387041508 cites W2810458489 @default.
- W4387041508 cites W2911258909 @default.
- W4387041508 cites W2983012744 @default.
- W4387041508 cites W2987578460 @default.
- W4387041508 cites W2992584895 @default.
- W4387041508 cites W3004626042 @default.
- W4387041508 cites W3018333173 @default.
- W4387041508 cites W3049234060 @default.
- W4387041508 cites W3126655217 @default.
- W4387041508 cites W3127835035 @default.
- W4387041508 cites W3184606829 @default.
- W4387041508 cites W3204296900 @default.
- W4387041508 cites W4206076964 @default.
- W4387041508 cites W4210916095 @default.
- W4387041508 cites W4308580168 @default.
- W4387041508 doi "https://doi.org/10.1016/j.ejphar.2023.176083" @default.
- W4387041508 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37769985" @default.
- W4387041508 hasPublicationYear "2023" @default.
- W4387041508 type Work @default.
- W4387041508 citedByCount "0" @default.
- W4387041508 crossrefType "journal-article" @default.
- W4387041508 hasAuthorship W4387041508A5009376390 @default.
- W4387041508 hasAuthorship W4387041508A5012343926 @default.
- W4387041508 hasAuthorship W4387041508A5020091276 @default.
- W4387041508 hasAuthorship W4387041508A5033572460 @default.
- W4387041508 hasAuthorship W4387041508A5053842104 @default.
- W4387041508 hasAuthorship W4387041508A5066672804 @default.
- W4387041508 hasConcept C126322002 @default.
- W4387041508 hasConcept C134018914 @default.
- W4387041508 hasConcept C141071460 @default.
- W4387041508 hasConcept C147990577 @default.
- W4387041508 hasConcept C18903297 @default.
- W4387041508 hasConcept C2776061955 @default.
- W4387041508 hasConcept C2776151105 @default.
- W4387041508 hasConcept C2777858829 @default.
- W4387041508 hasConcept C2778144972 @default.
- W4387041508 hasConcept C2779280383 @default.
- W4387041508 hasConcept C2779719074 @default.
- W4387041508 hasConcept C2780269544 @default.
- W4387041508 hasConcept C519536355 @default.
- W4387041508 hasConcept C555293320 @default.
- W4387041508 hasConcept C71924100 @default.
- W4387041508 hasConcept C86803240 @default.
- W4387041508 hasConceptScore W4387041508C126322002 @default.
- W4387041508 hasConceptScore W4387041508C134018914 @default.
- W4387041508 hasConceptScore W4387041508C141071460 @default.
- W4387041508 hasConceptScore W4387041508C147990577 @default.
- W4387041508 hasConceptScore W4387041508C18903297 @default.
- W4387041508 hasConceptScore W4387041508C2776061955 @default.
- W4387041508 hasConceptScore W4387041508C2776151105 @default.
- W4387041508 hasConceptScore W4387041508C2777858829 @default.
- W4387041508 hasConceptScore W4387041508C2778144972 @default.
- W4387041508 hasConceptScore W4387041508C2779280383 @default.
- W4387041508 hasConceptScore W4387041508C2779719074 @default.