FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387045724> ?p ?o ?g. }

• W4387045724 abstract "Abstract Quorum sensing is the process by which bacterial cells can communicate by producing substances to regulate viable processes such as gene expression, virulence, and biofilm formation. Gram-positive bacteria such as Staphylococcus aureus and Enterococcus faecalis have specific enzymes (autoinducers) that control the quorum sensing system. Sortase A is a surface protein that regulates virulence and cell‒cell communication in Gram-positive bacteria. To interfere with this system and reduce virulence and cell‒cell communication, quorum sensing inhibitors are used, which are nonantibiotic substances. In this study, we aimed to use Food and Drug Administration-approved drugs (analgesics and antipsychotics) and investigate their activity using molecular docking and microbiological assays against both quorum sensing in Gram-positive S. aureus and E. faecalis. This study investigated the quorum sensing inhibitors acetylsalicylic acid and trifluoperazine and evaluated their affinity to the active site of SrtA (PDB:1t2w) using AutoDock Vina software. Agar diffusion and minimum inhibitory concentration tests were performed to experimentally validate the quorum sensing inhibitor activity of acetylsalicylic acid and trifluoperazine. Molecular docking illustrated that acetylsalicylic acid and trifluoperazine have high affinity as quorum sensing inhibitors in both S. aureus and E. faecalis. However, only acetylsalicylic acid showed inhibition activity at 1000 µg/ml in E. faecalis and at 250 µg/ml by the agar well diffusion method in S. aureus. The high affinity of these quorum sensing inhibitors, as presented by the molecular docking and inhibition of growth experiments, are indications of their ability to act as quorum sensing inhibitors and as promising synergistic with nonantibiotic drugs to treat infection." @default.
• W4387045724 created "2023-09-27" @default.
• W4387045724 creator A5027759701 @default.
• W4387045724 creator A5029330727 @default.
• W4387045724 creator A5074391759 @default.
• W4387045724 creator A5092943234 @default.
• W4387045724 creator A5092943235 @default.
• W4387045724 date "2023-09-26" @default.
• W4387045724 modified "2023-10-16" @default.
• W4387045724 title "In silico identification of new potential inhibitors of quorum sensing by Gram-positive bacteria through specialized molecular docking" @default.
• W4387045724 cites W1573067122 @default.
• W4387045724 cites W1887624773 @default.
• W4387045724 cites W1975613378 @default.
• W4387045724 cites W1980957722 @default.
• W4387045724 cites W1982537960 @default.
• W4387045724 cites W1987837071 @default.
• W4387045724 cites W2006155478 @default.
• W4387045724 cites W2015154615 @default.
• W4387045724 cites W2040605556 @default.
• W4387045724 cites W2062521206 @default.
• W4387045724 cites W2068086276 @default.
• W4387045724 cites W2091710634 @default.
• W4387045724 cites W2120857280 @default.
• W4387045724 cites W2126894693 @default.
• W4387045724 cites W2126922170 @default.
• W4387045724 cites W2137085824 @default.
• W4387045724 cites W2138648191 @default.
• W4387045724 cites W2144501842 @default.
• W4387045724 cites W2145877521 @default.
• W4387045724 cites W2159721904 @default.
• W4387045724 cites W2165615238 @default.
• W4387045724 cites W2166550586 @default.
• W4387045724 cites W2312895436 @default.
• W4387045724 cites W2319408189 @default.
• W4387045724 cites W2409858324 @default.
• W4387045724 cites W2533325435 @default.
• W4387045724 cites W2580560999 @default.
• W4387045724 cites W2725837350 @default.
• W4387045724 cites W2887766329 @default.
• W4387045724 cites W2896002881 @default.
• W4387045724 cites W2913198824 @default.
• W4387045724 cites W2913573831 @default.
• W4387045724 cites W2947314486 @default.
• W4387045724 cites W2954297401 @default.
• W4387045724 cites W2955426417 @default.
• W4387045724 cites W3005021171 @default.
• W4387045724 cites W3012106863 @default.
• W4387045724 cites W3042576497 @default.
• W4387045724 cites W3135489256 @default.
• W4387045724 cites W3157707661 @default.
• W4387045724 cites W3209230852 @default.
• W4387045724 cites W4239852528 @default.
• W4387045724 cites W4281493823 @default.
• W4387045724 cites W787318908 @default.
• W4387045724 doi "https://doi.org/10.1007/s43994-023-00080-3" @default.
• W4387045724 hasPublicationYear "2023" @default.
• W4387045724 type Work @default.
• W4387045724 citedByCount "0" @default.
• W4387045724 crossrefType "journal-article" @default.
• W4387045724 hasAuthorship W4387045724A5027759701 @default.
• W4387045724 hasAuthorship W4387045724A5029330727 @default.
• W4387045724 hasAuthorship W4387045724A5074391759 @default.
• W4387045724 hasAuthorship W4387045724A5092943234 @default.
• W4387045724 hasAuthorship W4387045724A5092943235 @default.
• W4387045724 hasBestOaLocation W43870457241 @default.
• W4387045724 hasConcept C104317684 @default.
• W4387045724 hasConcept C118687296 @default.
• W4387045724 hasConcept C159110408 @default.
• W4387045724 hasConcept C185592680 @default.
• W4387045724 hasConcept C19655278 @default.
• W4387045724 hasConcept C2775905019 @default.
• W4387045724 hasConcept C2778839769 @default.
• W4387045724 hasConcept C2779489039 @default.
• W4387045724 hasConcept C2779895986 @default.
• W4387045724 hasConcept C41685203 @default.
• W4387045724 hasConcept C523546767 @default.
• W4387045724 hasConcept C54355233 @default.
• W4387045724 hasConcept C55493867 @default.
• W4387045724 hasConcept C58123911 @default.
• W4387045724 hasConcept C60987743 @default.
• W4387045724 hasConcept C71924100 @default.
• W4387045724 hasConcept C86803240 @default.
• W4387045724 hasConcept C89423630 @default.
• W4387045724 hasConcept C95282255 @default.
• W4387045724 hasConceptScore W4387045724C104317684 @default.
• W4387045724 hasConceptScore W4387045724C118687296 @default.
• W4387045724 hasConceptScore W4387045724C159110408 @default.
• W4387045724 hasConceptScore W4387045724C185592680 @default.
• W4387045724 hasConceptScore W4387045724C19655278 @default.
• W4387045724 hasConceptScore W4387045724C2775905019 @default.
• W4387045724 hasConceptScore W4387045724C2778839769 @default.
• W4387045724 hasConceptScore W4387045724C2779489039 @default.
• W4387045724 hasConceptScore W4387045724C2779895986 @default.
• W4387045724 hasConceptScore W4387045724C41685203 @default.
• W4387045724 hasConceptScore W4387045724C523546767 @default.
• W4387045724 hasConceptScore W4387045724C54355233 @default.
• W4387045724 hasConceptScore W4387045724C55493867 @default.
• W4387045724 hasConceptScore W4387045724C58123911 @default.
• W4387045724 hasConceptScore W4387045724C60987743 @default.
• W4387045724 hasConceptScore W4387045724C71924100 @default.

• next