Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387046244> ?p ?o ?g. }
- W4387046244 endingPage "216413" @default.
- W4387046244 startingPage "216413" @default.
- W4387046244 abstract "Immune checkpoint blockade therapy has revolutionized the field of cancer treatment, leading to durable responses in patients with advanced and metastatic cancers where conventional therapies were insufficient. However, factors like immunosuppressive cells and immune checkpoint molecules within the tumor microenvironment (TME) can suppress the immune system and thus negatively affect the efficiency of immune checkpoint inhibitors. Pyroptosis, a gasdermin-induced programmed cell death, could transform cold tumors to hot tumors to improve the milieu of TME, thus enhancing the immune response and preventing tumor growth. Recently, evidence showed that epigenetics could regulate pyroptosis, which further affects tumorigenesis, suggesting that epigenetics-based tumor cells pyroptosis could be a promising therapeutic strategy. Hence, this review focuses on the pyroptotic mechanism and summarizes three common types of epigenetics, DNA methylation, histone modification, and non-coding RNA, all of which have a role in regulating the expression of transcription factors and proteins involved in pyroptosis in cancer. Especially, we discuss targeting strategies on epigenetic-regulated pyroptosis and provide insights on the future trend of cancer research which may fuel cancer therapies into a new step." @default.
- W4387046244 created "2023-09-27" @default.
- W4387046244 creator A5006266198 @default.
- W4387046244 creator A5032881192 @default.
- W4387046244 creator A5044766711 @default.
- W4387046244 creator A5079972337 @default.
- W4387046244 date "2023-10-01" @default.
- W4387046244 modified "2023-10-07" @default.
- W4387046244 title "Epigenetic regulation of pyroptosis in cancer: Molecular pathogenesis and targeting strategies" @default.
- W4387046244 cites W1529674879 @default.
- W4387046244 cites W1663536395 @default.
- W4387046244 cites W1882905539 @default.
- W4387046244 cites W1941339056 @default.
- W4387046244 cites W1967334449 @default.
- W4387046244 cites W1978660434 @default.
- W4387046244 cites W1999460825 @default.
- W4387046244 cites W2000090224 @default.
- W4387046244 cites W2004172747 @default.
- W4387046244 cites W2010287588 @default.
- W4387046244 cites W2029746613 @default.
- W4387046244 cites W2079882002 @default.
- W4387046244 cites W2095242372 @default.
- W4387046244 cites W2265419075 @default.
- W4387046244 cites W2301157369 @default.
- W4387046244 cites W2463708289 @default.
- W4387046244 cites W2564122215 @default.
- W4387046244 cites W2591639353 @default.
- W4387046244 cites W2596054989 @default.
- W4387046244 cites W2605255264 @default.
- W4387046244 cites W2608687752 @default.
- W4387046244 cites W2725398806 @default.
- W4387046244 cites W2748881498 @default.
- W4387046244 cites W2783618610 @default.
- W4387046244 cites W2802115757 @default.
- W4387046244 cites W2889823397 @default.
- W4387046244 cites W2894328098 @default.
- W4387046244 cites W2898289679 @default.
- W4387046244 cites W2900507152 @default.
- W4387046244 cites W2912896196 @default.
- W4387046244 cites W2920068846 @default.
- W4387046244 cites W2945002892 @default.
- W4387046244 cites W2972758365 @default.
- W4387046244 cites W2974304113 @default.
- W4387046244 cites W2976271971 @default.
- W4387046244 cites W2977026913 @default.
- W4387046244 cites W2979879967 @default.
- W4387046244 cites W2983652778 @default.
- W4387046244 cites W2989083977 @default.
- W4387046244 cites W2996313857 @default.
- W4387046244 cites W2999534343 @default.
- W4387046244 cites W3003551870 @default.
- W4387046244 cites W3010700815 @default.
- W4387046244 cites W3012485477 @default.
- W4387046244 cites W3013736176 @default.
- W4387046244 cites W3013856967 @default.
- W4387046244 cites W3014576212 @default.
- W4387046244 cites W3016675545 @default.
- W4387046244 cites W3016811071 @default.
- W4387046244 cites W3018541786 @default.
- W4387046244 cites W3030553520 @default.
- W4387046244 cites W3033191323 @default.
- W4387046244 cites W3042107687 @default.
- W4387046244 cites W3044471567 @default.
- W4387046244 cites W3047602940 @default.
- W4387046244 cites W3048653545 @default.
- W4387046244 cites W3084494759 @default.
- W4387046244 cites W3092400718 @default.
- W4387046244 cites W3113195716 @default.
- W4387046244 cites W3118458553 @default.
- W4387046244 cites W3127004122 @default.
- W4387046244 cites W3133536578 @default.
- W4387046244 cites W3135641447 @default.
- W4387046244 cites W3137422569 @default.
- W4387046244 cites W3138339791 @default.
- W4387046244 cites W3142080073 @default.
- W4387046244 cites W3163284831 @default.
- W4387046244 cites W3183286210 @default.
- W4387046244 cites W3201399941 @default.
- W4387046244 cites W3203575974 @default.
- W4387046244 cites W4205328155 @default.
- W4387046244 cites W4212932622 @default.
- W4387046244 cites W4213089954 @default.
- W4387046244 cites W4220713828 @default.
- W4387046244 cites W4223500161 @default.
- W4387046244 cites W4224936668 @default.
- W4387046244 cites W4225117243 @default.
- W4387046244 cites W4280644103 @default.
- W4387046244 cites W4283219601 @default.
- W4387046244 cites W4283798609 @default.
- W4387046244 cites W4289525443 @default.
- W4387046244 cites W4289598317 @default.
- W4387046244 cites W4295011627 @default.
- W4387046244 cites W4301391425 @default.
- W4387046244 cites W4304471387 @default.
- W4387046244 cites W4308147670 @default.
- W4387046244 cites W4308348622 @default.
- W4387046244 cites W4311955174 @default.
- W4387046244 cites W4321793310 @default.