FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387046368> ?p ?o ?g. }

• W4387046368 endingPage "105704" @default.
• W4387046368 startingPage "105704" @default.
• W4387046368 abstract "Trastuzumab (TRZ) is a novel targeted anti-tumor agent that significantly improve the survival of patients with human epidermal growth factor receptor (HER2) positive breast cancer. However, its clinical application is limited due to the side effects of cardiotoxicity. Osthol (OST), a coumarin derivative isolated from Cnidium monnieri (L.) Cusson, has previously demonstrated cardioprotective effects. The aim of this study was to observe the protective effect of OST on TRZ-induced cardiomyocytes damage and to explore its potential mechanism. The results showed that OST pretreatment could significantly inhibit TRZ-induced cardiomyocytes damage, and markedly increase the ratio of LC3II/I and Beclin-1 protein expression, and reduce the protein expression of p62. OST pretreatment significantly attenuated oxidative stress and apoptosis induced by TRZ, as evidenced by reducing intracellular ROS level, Bax/Bcl-2 ratio, and Caspase-3 protein expression. Additionally, OST markedly increased the phosphorylation level of p38MAPK and decreased mTOR phosphorylation level. However, the effects of OST on enhancing autophagy, reducing oxidative stress, apoptosis and the phosphorylation level of mTOR were reversed after the addition of 3-MA or SB203580. Molecular docking results indicated that OST exerted a good binding ability with p38MAPK protein. Our findings suggested that OST could protect TRZ-induced cardiomyocytes damage by enhancing autophagy via the p38MAPK/mTOR signaling pathway." @default.
• W4387046368 created "2023-09-27" @default.
• W4387046368 creator A5013478611 @default.
• W4387046368 creator A5023962135 @default.
• W4387046368 creator A5063514061 @default.
• W4387046368 creator A5079827153 @default.
• W4387046368 date "2023-12-01" @default.
• W4387046368 modified "2023-10-03" @default.
• W4387046368 title "Osthole protects H9c2 cardiomyocytes against trastuzumab-induced damage by enhancing autophagy through the p38MAPK/mTOR signaling pathway" @default.
• W4387046368 cites W1928191263 @default.
• W4387046368 cites W1965766554 @default.
• W4387046368 cites W1998334997 @default.
• W4387046368 cites W2004012896 @default.
• W4387046368 cites W2051449338 @default.
• W4387046368 cites W2058909257 @default.
• W4387046368 cites W2059137112 @default.
• W4387046368 cites W2070515279 @default.
• W4387046368 cites W2074170320 @default.
• W4387046368 cites W2082398895 @default.
• W4387046368 cites W2085163888 @default.
• W4387046368 cites W2086525709 @default.
• W4387046368 cites W2093870248 @default.
• W4387046368 cites W2167141775 @default.
• W4387046368 cites W2330366426 @default.
• W4387046368 cites W2341881834 @default.
• W4387046368 cites W2514340051 @default.
• W4387046368 cites W2528999955 @default.
• W4387046368 cites W2606436918 @default.
• W4387046368 cites W2770088926 @default.
• W4387046368 cites W2897470657 @default.
• W4387046368 cites W2976013438 @default.
• W4387046368 cites W2981328279 @default.
• W4387046368 cites W2987519833 @default.
• W4387046368 cites W3007470603 @default.
• W4387046368 cites W3033684458 @default.
• W4387046368 cites W3048138702 @default.
• W4387046368 cites W3119711869 @default.
• W4387046368 cites W3134933214 @default.
• W4387046368 cites W3156623499 @default.
• W4387046368 cites W3170674626 @default.
• W4387046368 cites W3178815355 @default.
• W4387046368 cites W3199410205 @default.
• W4387046368 cites W4206757514 @default.
• W4387046368 cites W4312085343 @default.
• W4387046368 cites W4323364814 @default.
• W4387046368 doi "https://doi.org/10.1016/j.tiv.2023.105704" @default.
• W4387046368 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37769856" @default.
• W4387046368 hasPublicationYear "2023" @default.
• W4387046368 type Work @default.
• W4387046368 citedByCount "0" @default.
• W4387046368 crossrefType "journal-article" @default.
• W4387046368 hasAuthorship W4387046368A5013478611 @default.
• W4387046368 hasAuthorship W4387046368A5023962135 @default.
• W4387046368 hasAuthorship W4387046368A5063514061 @default.
• W4387046368 hasAuthorship W4387046368A5079827153 @default.
• W4387046368 hasConcept C11960822 @default.
• W4387046368 hasConcept C178790620 @default.
• W4387046368 hasConcept C185592680 @default.
• W4387046368 hasConcept C190283241 @default.
• W4387046368 hasConcept C203522944 @default.
• W4387046368 hasConcept C2776151105 @default.
• W4387046368 hasConcept C2778233292 @default.
• W4387046368 hasConcept C29730261 @default.
• W4387046368 hasConcept C502942594 @default.
• W4387046368 hasConcept C55493867 @default.
• W4387046368 hasConcept C62478195 @default.
• W4387046368 hasConcept C71924100 @default.
• W4387046368 hasConcept C75217442 @default.
• W4387046368 hasConcept C79879829 @default.
• W4387046368 hasConcept C86554907 @default.
• W4387046368 hasConcept C86803240 @default.
• W4387046368 hasConcept C95444343 @default.
• W4387046368 hasConcept C98274493 @default.
• W4387046368 hasConceptScore W4387046368C11960822 @default.
• W4387046368 hasConceptScore W4387046368C178790620 @default.
• W4387046368 hasConceptScore W4387046368C185592680 @default.
• W4387046368 hasConceptScore W4387046368C190283241 @default.
• W4387046368 hasConceptScore W4387046368C203522944 @default.
• W4387046368 hasConceptScore W4387046368C2776151105 @default.
• W4387046368 hasConceptScore W4387046368C2778233292 @default.
• W4387046368 hasConceptScore W4387046368C29730261 @default.
• W4387046368 hasConceptScore W4387046368C502942594 @default.
• W4387046368 hasConceptScore W4387046368C55493867 @default.
• W4387046368 hasConceptScore W4387046368C62478195 @default.
• W4387046368 hasConceptScore W4387046368C71924100 @default.
• W4387046368 hasConceptScore W4387046368C75217442 @default.
• W4387046368 hasConceptScore W4387046368C79879829 @default.
• W4387046368 hasConceptScore W4387046368C86554907 @default.
• W4387046368 hasConceptScore W4387046368C86803240 @default.
• W4387046368 hasConceptScore W4387046368C95444343 @default.
• W4387046368 hasConceptScore W4387046368C98274493 @default.
• W4387046368 hasLocation W43870463681 @default.
• W4387046368 hasLocation W43870463682 @default.
• W4387046368 hasOpenAccess W4387046368 @default.
• W4387046368 hasPrimaryLocation W43870463681 @default.
• W4387046368 hasRelatedWork W1585268103 @default.
• W4387046368 hasRelatedWork W2031322368 @default.
• W4387046368 hasRelatedWork W2127153258 @default.

• next