Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387047129> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W4387047129 endingPage "1214" @default.
- W4387047129 startingPage "1214" @default.
- W4387047129 abstract "<ns4:p><ns4:bold>Background:</ns4:bold> Recent evidence suggests that some flavonoid compounds obtained from crude methanol extract of mistletoe leaves (<ns4:italic>Dendrophthoe pentandra L. Miq</ns4:italic>), also known as Benalu Duku (BD), have antimicrobial effects. Thus, the plant has the potential to eliminate viruses that may cause outbreaks in chicken farms. This study aimed to prove the<ns4:italic> in vitro</ns4:italic> ability of flavonoid compounds, namely quercetin-like compounds (QLCs), to eliminate field viruses, specifically the Newcastle disease virus (NDV).</ns4:p><ns4:p> <ns4:bold>Methods:</ns4:bold> This research was performed in two stages. An <ns4:italic>in vitro</ns4:italic> test was used with a post-test of the control groups designed at a significance of 0.05. BD leaves (5 kg) were extracted using a maceration method with methanol and then separated into hexane, chloroform, ethyl acetate, and methanol fractions. The final extracted products were separated using semi-preparative high-performance liquid chromatography (HPLC) to obtain QLCs. The QLCs were identified and compared with quercetin using HPLC, proton and carbon nuclear magnetic resonance spectrometry, Fourier transform infrared spectrophotometry, and ultra-performance liquid chromatography–mass spectrometry. The activity of QLCs was tested <ns4:italic>in vitro</ns4:italic> against the NDV at a virulency titer of 10<ns4:sup>−5</ns4:sup> Tissue Culture Infectious Dose 50% (TCID50) and in chicken kidney cell culture.</ns4:p><ns4:p> <ns4:bold>Results:</ns4:bold> Solutions of 0.05% (w/v) QLCs were discovered to have antiviral activity against NDVs, with an average cytopathogenic effect antigenicity at a 10<ns4:sup>−5</ns4:sup> dilution (p<0.05).</ns4:p><ns4:p> <ns4:bold>Conclusions:</ns4:bold> QLCs from flavonoids from the leaves of BD have antiviral bioactivity against NDVs and may have the potential to be developed as medicinal compounds for the treatment of other human or animal viral infections.</ns4:p>" @default.
- W4387047129 created "2023-09-27" @default.
- W4387047129 creator A5058328039 @default.
- W4387047129 creator A5067313111 @default.
- W4387047129 creator A5083122112 @default.
- W4387047129 creator A5084206178 @default.
- W4387047129 date "2023-09-26" @default.
- W4387047129 modified "2023-09-30" @default.
- W4387047129 title "In vitro analysis of quercetin-like compounds from mistletoe Dendrophthoe pentandra (L.) Miq as a potential antiviral agent for Newcastle disease" @default.
- W4387047129 cites W1996334059 @default.
- W4387047129 cites W2093238533 @default.
- W4387047129 cites W2138595118 @default.
- W4387047129 cites W2158421639 @default.
- W4387047129 cites W2294701553 @default.
- W4387047129 cites W2337645272 @default.
- W4387047129 cites W2487885777 @default.
- W4387047129 cites W2741206764 @default.
- W4387047129 cites W2918551010 @default.
- W4387047129 cites W2954294089 @default.
- W4387047129 cites W3005276061 @default.
- W4387047129 cites W3024707013 @default.
- W4387047129 cites W3121596726 @default.
- W4387047129 cites W3128061772 @default.
- W4387047129 cites W3208203763 @default.
- W4387047129 cites W4210536376 @default.
- W4387047129 cites W4213444150 @default.
- W4387047129 cites W4220742576 @default.
- W4387047129 cites W4223419062 @default.
- W4387047129 cites W4224287561 @default.
- W4387047129 cites W4224442536 @default.
- W4387047129 cites W4225312570 @default.
- W4387047129 cites W4225410156 @default.
- W4387047129 cites W4226410482 @default.
- W4387047129 cites W4280517075 @default.
- W4387047129 cites W4280591394 @default.
- W4387047129 cites W4283071258 @default.
- W4387047129 cites W4289521329 @default.
- W4387047129 cites W4294844268 @default.
- W4387047129 cites W4304775423 @default.
- W4387047129 cites W4309725805 @default.
- W4387047129 cites W4309998798 @default.
- W4387047129 cites W4311945414 @default.
- W4387047129 cites W4312043189 @default.
- W4387047129 cites W4312082417 @default.
- W4387047129 cites W4312115025 @default.
- W4387047129 cites W4312141130 @default.
- W4387047129 cites W4312224035 @default.
- W4387047129 cites W4313825991 @default.
- W4387047129 cites W4318475503 @default.
- W4387047129 cites W8288655 @default.
- W4387047129 doi "https://doi.org/10.12688/f1000research.133489.1" @default.
- W4387047129 hasPublicationYear "2023" @default.
- W4387047129 type Work @default.
- W4387047129 citedByCount "0" @default.
- W4387047129 crossrefType "journal-article" @default.
- W4387047129 hasAuthorship W4387047129A5058328039 @default.
- W4387047129 hasAuthorship W4387047129A5067313111 @default.
- W4387047129 hasAuthorship W4387047129A5083122112 @default.
- W4387047129 hasAuthorship W4387047129A5084206178 @default.
- W4387047129 hasBestOaLocation W43870471291 @default.
- W4387047129 hasConcept C2778004101 @default.
- W4387047129 hasConcept C2779054382 @default.
- W4387047129 hasConcept C2781263971 @default.
- W4387047129 hasConcept C55493867 @default.
- W4387047129 hasConcept C556039675 @default.
- W4387047129 hasConcept C71924100 @default.
- W4387047129 hasConcept C86803240 @default.
- W4387047129 hasConceptScore W4387047129C2778004101 @default.
- W4387047129 hasConceptScore W4387047129C2779054382 @default.
- W4387047129 hasConceptScore W4387047129C2781263971 @default.
- W4387047129 hasConceptScore W4387047129C55493867 @default.
- W4387047129 hasConceptScore W4387047129C556039675 @default.
- W4387047129 hasConceptScore W4387047129C71924100 @default.
- W4387047129 hasConceptScore W4387047129C86803240 @default.
- W4387047129 hasLocation W43870471291 @default.
- W4387047129 hasOpenAccess W4387047129 @default.
- W4387047129 hasPrimaryLocation W43870471291 @default.
- W4387047129 hasRelatedWork W1993323069 @default.
- W4387047129 hasRelatedWork W1999618802 @default.
- W4387047129 hasRelatedWork W2005426509 @default.
- W4387047129 hasRelatedWork W2077900998 @default.
- W4387047129 hasRelatedWork W2081187091 @default.
- W4387047129 hasRelatedWork W2315510413 @default.
- W4387047129 hasRelatedWork W2614678177 @default.
- W4387047129 hasRelatedWork W2900017146 @default.
- W4387047129 hasRelatedWork W3089526588 @default.
- W4387047129 hasRelatedWork W4366370468 @default.
- W4387047129 hasVolume "12" @default.
- W4387047129 isParatext "false" @default.
- W4387047129 isRetracted "false" @default.
- W4387047129 workType "article" @default.