Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387048304> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W4387048304 abstract "Multicellular organisms are composed of specialized cells with distinct proteomes. While recent advances in single-cell transcriptome analyses have revealed differential expression of mRNAs, cellular diversity in translational profiles remains to be understood. In this study, by performing RNA-seq and ribo-seq in genetically-defined cells in the Drosophila brain, we revealed substantial posttranscriptional regulations that augment the cell-type distinctions. Specifically, we found that translational efficiency of proteins fundamental to neuronal functions, such as ion channels and neurotransmitter receptors, was maintained low in glia, leading to preferential translation in neurons. Notably, distribution of ribosome footprints on these mRNAs exhibited a remarkable bias towards the 5′ untranslated regions (UTR) in glia. Using a transgenic reporter, we provide evidence that the UTR confer translational suppression selectively in glia. Overall, these findings underscore the profound impact of translational regulation in shaping cell identity and provide new insights into the molecular mechanisms driving cell-type diversity." @default.
- W4387048304 created "2023-09-27" @default.
- W4387048304 date "2023-09-26" @default.
- W4387048304 modified "2023-09-27" @default.
- W4387048304 title "Reviewer #3 (Public Review): Translational regulation enhances distinction of cell types in the nervous system" @default.
- W4387048304 doi "https://doi.org/10.7554/elife.90713.1.sa3" @default.
- W4387048304 hasPublicationYear "2023" @default.
- W4387048304 type Work @default.
- W4387048304 citedByCount "0" @default.
- W4387048304 crossrefType "peer-review" @default.
- W4387048304 hasBestOaLocation W43870483041 @default.
- W4387048304 hasConcept C104317684 @default.
- W4387048304 hasConcept C104397665 @default.
- W4387048304 hasConcept C105580179 @default.
- W4387048304 hasConcept C1491633281 @default.
- W4387048304 hasConcept C149364088 @default.
- W4387048304 hasConcept C150194340 @default.
- W4387048304 hasConcept C162317418 @default.
- W4387048304 hasConcept C169760540 @default.
- W4387048304 hasConcept C189014844 @default.
- W4387048304 hasConcept C22667442 @default.
- W4387048304 hasConcept C3675279 @default.
- W4387048304 hasConcept C39685955 @default.
- W4387048304 hasConcept C54355233 @default.
- W4387048304 hasConcept C70721500 @default.
- W4387048304 hasConcept C74318829 @default.
- W4387048304 hasConcept C86803240 @default.
- W4387048304 hasConcept C89604277 @default.
- W4387048304 hasConcept C95444343 @default.
- W4387048304 hasConceptScore W4387048304C104317684 @default.
- W4387048304 hasConceptScore W4387048304C104397665 @default.
- W4387048304 hasConceptScore W4387048304C105580179 @default.
- W4387048304 hasConceptScore W4387048304C1491633281 @default.
- W4387048304 hasConceptScore W4387048304C149364088 @default.
- W4387048304 hasConceptScore W4387048304C150194340 @default.
- W4387048304 hasConceptScore W4387048304C162317418 @default.
- W4387048304 hasConceptScore W4387048304C169760540 @default.
- W4387048304 hasConceptScore W4387048304C189014844 @default.
- W4387048304 hasConceptScore W4387048304C22667442 @default.
- W4387048304 hasConceptScore W4387048304C3675279 @default.
- W4387048304 hasConceptScore W4387048304C39685955 @default.
- W4387048304 hasConceptScore W4387048304C54355233 @default.
- W4387048304 hasConceptScore W4387048304C70721500 @default.
- W4387048304 hasConceptScore W4387048304C74318829 @default.
- W4387048304 hasConceptScore W4387048304C86803240 @default.
- W4387048304 hasConceptScore W4387048304C89604277 @default.
- W4387048304 hasConceptScore W4387048304C95444343 @default.
- W4387048304 hasLocation W43870483041 @default.
- W4387048304 hasOpenAccess W4387048304 @default.
- W4387048304 hasPrimaryLocation W43870483041 @default.
- W4387048304 hasRelatedWork W1947010805 @default.
- W4387048304 hasRelatedWork W1992935306 @default.
- W4387048304 hasRelatedWork W2036661917 @default.
- W4387048304 hasRelatedWork W2062021343 @default.
- W4387048304 hasRelatedWork W2077921152 @default.
- W4387048304 hasRelatedWork W2122103373 @default.
- W4387048304 hasRelatedWork W2145047295 @default.
- W4387048304 hasRelatedWork W3023577933 @default.
- W4387048304 hasRelatedWork W4213030072 @default.
- W4387048304 hasRelatedWork W4313210658 @default.
- W4387048304 isParatext "false" @default.
- W4387048304 isRetracted "false" @default.
- W4387048304 workType "peer-review" @default.