FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387048315> ?p ?o ?g. }

• W4387048315 endingPage "968" @default.
• W4387048315 startingPage "968" @default.
• W4387048315 abstract "Cryptococcosis is a systemic mycosis that causes pneumonia and meningoencephalitis. Strongyloidiasis is a chronic gastrointestinal infection caused by parasites of the genus Strongyloides. Cryptococcosis and strongyloidiasis affect the lungs and are more prevalent in the same world regions, i.e., Africa and tropical countries such as Brazil. It is undeniable that those coincidences may lead to the occurrence of coinfections. However, there are no studies focused on the interaction between Cryptococcus spp. and Strongyloides spp. In this work, we aimed to investigate the interaction between Strongyloides venezuelensis (Sv) and Cryptococcus gattii (Cg) in a murine coinfection model. Murine macrophage exposure to Sv antigens reduced their ability to engulf Cg and produce reactive oxygen species, increasing the ability of fungal growth intracellularly. We then infected mice with both pathogens. Sv infection skewed the host’s response to fungal infection, increasing lethality in a murine coinfection model. In addition to increased NO levels and arginase activity, coinfected mice presented a classic Th2 anti-Sv response: eosinophilia, higher levels of alternate activated macrophages (M2), increased concentrations of CCL24 and IL-4, and lower levels of IL-1β. This milieu favored fungal growth in the lungs with prominent translocation to the brain, increasing the host’s tissue damage. In conclusion, our data shows that primary Sv infection promotes Th2 bias of the pulmonary response to Cg-infection and worsens its pathological outcomes." @default.
• W4387048315 created "2023-09-27" @default.
• W4387048315 creator A5001815687 @default.
• W4387048315 creator A5005467169 @default.
• W4387048315 creator A5005880397 @default.
• W4387048315 creator A5011370349 @default.
• W4387048315 creator A5017755825 @default.
• W4387048315 creator A5023515671 @default.
• W4387048315 creator A5034050581 @default.
• W4387048315 creator A5041929307 @default.
• W4387048315 creator A5043523399 @default.
• W4387048315 creator A5046993013 @default.
• W4387048315 creator A5050320347 @default.
• W4387048315 creator A5050419929 @default.
• W4387048315 creator A5053439787 @default.
• W4387048315 creator A5061154663 @default.
• W4387048315 creator A5065221735 @default.
• W4387048315 creator A5067919690 @default.
• W4387048315 creator A5076649716 @default.
• W4387048315 creator A5080754866 @default.
• W4387048315 creator A5087284274 @default.
• W4387048315 date "2023-09-26" @default.
• W4387048315 modified "2023-09-27" @default.
• W4387048315 title "The Th2 Response and Alternative Activation of Macrophages Triggered by Strongyloides venezuelensis Is Linked to Increased Morbidity and Mortality Due to Cryptococcosis in Mice" @default.
• W4387048315 cites W1215929254 @default.
• W4387048315 cites W1490724351 @default.
• W4387048315 cites W1549910311 @default.
• W4387048315 cites W1604499845 @default.
• W4387048315 cites W1653746199 @default.
• W4387048315 cites W1775749144 @default.
• W4387048315 cites W1975088467 @default.
• W4387048315 cites W1979839129 @default.
• W4387048315 cites W1993162648 @default.
• W4387048315 cites W1994648408 @default.
• W4387048315 cites W1996805077 @default.
• W4387048315 cites W1997183034 @default.
• W4387048315 cites W2005075125 @default.
• W4387048315 cites W2008392955 @default.
• W4387048315 cites W2010719574 @default.
• W4387048315 cites W2013666305 @default.
• W4387048315 cites W2020904791 @default.
• W4387048315 cites W2021084899 @default.
• W4387048315 cites W2035949542 @default.
• W4387048315 cites W2037663265 @default.
• W4387048315 cites W2056241473 @default.
• W4387048315 cites W2061003535 @default.
• W4387048315 cites W2081662576 @default.
• W4387048315 cites W2087234685 @default.
• W4387048315 cites W2089868234 @default.
• W4387048315 cites W2095927264 @default.
• W4387048315 cites W2104449005 @default.
• W4387048315 cites W2114400198 @default.
• W4387048315 cites W2115579627 @default.
• W4387048315 cites W2139289419 @default.
• W4387048315 cites W2139426562 @default.
• W4387048315 cites W2141130205 @default.
• W4387048315 cites W2146171603 @default.
• W4387048315 cites W2154434805 @default.
• W4387048315 cites W2160097418 @default.
• W4387048315 cites W2162598140 @default.
• W4387048315 cites W2170859937 @default.
• W4387048315 cites W2170890641 @default.
• W4387048315 cites W2219027175 @default.
• W4387048315 cites W2233272919 @default.
• W4387048315 cites W2281417782 @default.
• W4387048315 cites W2289108571 @default.
• W4387048315 cites W2336604164 @default.
• W4387048315 cites W2399715995 @default.
• W4387048315 cites W2419693770 @default.
• W4387048315 cites W2580165056 @default.
• W4387048315 cites W2619252713 @default.
• W4387048315 cites W2756943820 @default.
• W4387048315 cites W2763204636 @default.
• W4387048315 cites W2793007013 @default.
• W4387048315 cites W2886793961 @default.
• W4387048315 cites W2889457421 @default.
• W4387048315 cites W2954730393 @default.
• W4387048315 cites W2969871827 @default.
• W4387048315 cites W2989753360 @default.
• W4387048315 cites W3003127115 @default.
• W4387048315 cites W3005328698 @default.
• W4387048315 cites W3014896296 @default.
• W4387048315 cites W3017342004 @default.
• W4387048315 cites W3034185235 @default.
• W4387048315 cites W3092017430 @default.
• W4387048315 cites W4224619015 @default.
• W4387048315 cites W4245214386 @default.
• W4387048315 cites W4293509742 @default.
• W4387048315 doi "https://doi.org/10.3390/jof9100968" @default.
• W4387048315 hasPublicationYear "2023" @default.
• W4387048315 type Work @default.
• W4387048315 citedByCount "0" @default.
• W4387048315 crossrefType "journal-article" @default.
• W4387048315 hasAuthorship W4387048315A5001815687 @default.
• W4387048315 hasAuthorship W4387048315A5005467169 @default.
• W4387048315 hasAuthorship W4387048315A5005880397 @default.
• W4387048315 hasAuthorship W4387048315A5011370349 @default.
• W4387048315 hasAuthorship W4387048315A5017755825 @default.

• next