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- W4387051007 abstract "The first total synthesis of the potent antimicrobial agent dynobactin A is disclosed. This synthesis capitalizes on the hidden symmetry present in this complex decapeptide by enlisting an aziridine ring opening strategy to access b-branched amino acids. Featuring a number of unique maneuvers to navigate inherently sensitive and epimerizable functional groups, this convergent approach proceeds in only 14 steps (LLS) from commercial materials and should facilitate the synthesis of numerous analogs for medicinal chemistry studies." @default.
- W4387051007 created "2023-09-27" @default.
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- W4387051007 date "2023-09-26" @default.
- W4387051007 modified "2023-10-12" @default.
- W4387051007 title "Total Synthesis of Dynobactin A" @default.
- W4387051007 doi "https://doi.org/10.26434/chemrxiv-2023-kw0xn" @default.
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