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• W4387052879 abstract "Previous research has shown increased platelet counts amongst firefighters exposed to rapid heat stress. However, the extent to which thermal strain contributes to immune responses (i.e., white blood cell count) in structural firefighters (SFF) warrants further investigation. Furthermore, whether desloratadine, an H1 antihistamine, can influence the heat-induced immune response remains to be investigated. PURPOSE: To evaluate the impact of rapid exertional heat stress (EHS) on SFF’s white blood cell (WBC) and platelet (PLT) count, and whether desloratadine influences the hematological response. METHODS: In two separate sessions, five male SFFs (Age: 31.6 +/- 6.44 yrs; Height: 1.91 +/- 0.06 m; Weight 94.83 +/- 12.53 kg; VO2max: 49.96 +/- 6.52 ml/kg/min) walked on a treadmill in structural firefighting protective equipment at 3.0 mph with a 5% incline until reaching volitional maximum or a core temperature (Tc) of 39.5 °C. Participants ingested 10 mg drug/placebo and a Tc capsule 2 hours prior to each session, with an identical drug/placebo dose 24 hours later. Venous blood samples were obtained immediately before, after, and 2-, 24-, 48-, and 72-hours post-heating. RESULTS: Tc increased by a mean of 1.89 +/- 0.44 °C during EHS. No significant differences between drug and placebo were observed for WBC; PLT; and number of lymphocytes (LY), monocytes (MO), neutrophils (NE), eosinophils (EO), and basophils (BA) (p > 0.05). All WBC, PLT, LY, MO, NE, EO, and BA showed significant differences over time following EHS (p < 0.05). Significant elevations in WBC, PLT, LY, & NE were found between baseline and either immediately post or 2 hours post testing (p < 0.05). In both conditions WBC count increased post-test by 36.02-42.35% from baseline (p < 0.05) and continued to increase to 68.76-87.17% 2 hours post-test (p < 0.05). By contrast, PLTs post-test increased by 45.13-49.80% from baseline (p < 0.05) and saw a recovery to 2.56-11.83% above baseline within 2 hours. CONCLUSION: EHS significantly impacts WBC markers and PLT counts within 72 hours post exposure. Desloratadine does not appear to influence these hematological responses." @default.
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• W4387052879 date "2023-09-01" @default.
• W4387052879 modified "2023-09-27" @default.
• W4387052879 title "Investigation Of The Effects Of Rapid Heat Acquisition And Desloratadine On Hematological Profiles Of Firefighters" @default.
• W4387052879 doi "https://doi.org/10.1249/01.mss.0000988484.57390.3b" @default.
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