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• W4387053001 abstract "PURPOSE: The purpose of this investigation was to examine the chronic effects of low-load blood flow restricted (LLBFR) and traditional (TRAD) moderate-load resistance training on neuromuscular and muscle function among people living with multiple sclerosis (PwMS). METHODS: Seven women (mean age ± SD = 39 ± 14 yrs; body mass = 70.2 ± 15.2 kg; height = 164.3 ± 6.8 cm) with relapsing-remitting multiple sclerosis participated in 12 weeks (2/wk) of LLBFR (n = 4) or TRAD (n = 3) consisting of bilateral upper body (chest press, seated row, shoulder press) and bilateral lower body (leg press, leg extension, leg curl) exercises. LLBFR performed 75 repetitions (1 × 30, 3 × 15) at 30% of one-repetition maximum (1RM) with a pneumatic cuff pressurized to 60% of total arterial occlusion pressure and applied to the most proximal portion of the upper arms or legs. TRAD performed 35-40 repetitions (4 × 8-12) at 65% of 1RM. Every four weeks, surface electromyography (sEMG) of the vastus lateralis and maximal strength of the dominant and non-dominant legs were assessed, separately, during unilateral, concentric, isokinetic, leg extensions at 90°·s-1 using 2 (Group [LLBFR, TRAD]) × 4 (Time [baseline, 4-, 8-, 12-wks]) mixed factorial ANOVAs. RESULTS: There were no significant (p = 0.228-0.787) interactions or main effects for Group, but there were significant main effects for Time (p < 0.001-0.035). Normalized (to baseline) sEMG amplitude of the non-dominant leg increased from baseline, 4-wks (mean ± SD = 106.2 ± 7.4%), and 8-wks (118.6 ± 15.9%) to 12-wks (138.9 ± 26.8%). There were non-significant (p > 0.05) increases in sEMG amplitude at 12-wks (141.1 ± 36.6%) of the dominant leg. Concentric peak torque of the dominant and non-dominant legs increased from baseline (88.6 ± 12.5 Nm and 92.2 ± 15.5 Nm, respectively) to 8-wks (103.9 ± 14.7 Nm and 98.8 ± 15.2 Nm, respectively) and to 12-wks (123.5 ± 14.1 Nm and 106.1 ± 16.5 Nm, respectively). CONCLUSIONS: Bilateral resistance exercise (LLBFR and TRAD) was effective at improving unilateral muscle strength, while local muscle excitation increased for only the non-dominant leg. These findings highlight the utility of LLBFR and TRAD resistance exercise to improve muscle outcomes among PwMS, but bilateral resistance exercise may exhibit non-homogenous adaptations between limbs." @default.
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• W4387053001 date "2023-09-01" @default.
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• W4387053001 title "Resistance Exercise Improves Muscle Strength And Neuromuscular Function Among People Living With Multiple Sclerosis" @default.
• W4387053001 doi "https://doi.org/10.1249/01.mss.0000988776.44876.4c" @default.
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