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- W4387053062 abstract "PURPOSE: Hyperacute serum is a blood-derived product obtained from the serum fraction of platelet rich fibrin. It has been observed that similar blood-derived products, such as platelet-rich plasma (PRP) induce improvements in injured or degenerative knee joints in terms of pain and mobility. However, manufacturing processes for PRP are not able to produce a standarized product, leading to high batch to batch variability, a limitation overcome by hyperacute serum. This study is a first-in-man study of hyperacute serum in patients with early-stage osteoarthritis. METHODS: 24 patients underwent 3 autologous hyperacute serum intraarticular knee injections. Clinical monitoring was followed up at 3 and 6 months and the outcome was validated by VAS, KOOS and Lysholm scores. Synovial fluid was collected for cytokine profile analysis. RESULTS: VAS, KOOS and Lysholm scores showed an improvement in pain and mobility. Principal component analysis of cytokine levels identified two groups with a high correlation between proteins. Group A was a more compact group in terms of expression, with 9 out of 10 cytokines been upregulated. It consisted on the following proteins: IL-8, MMP-9, fractalkine, IFNγ, IL-1β, IL-10, IL-1ra, IL-33, resistin and RANKL. On the other hand, Group B was a more heterogeneous group with more diversity in individual behaviour, still with a connection between the cytokines, including MMP-3, IL-2, IL-5, VEGF-A, aggrecan, CCL-3, COL1a, IL-12p70, IL-2, IL-23, LIF, OSM and TNFα. CONCLUSIONS: Patient reported outcomes following hyperacute serum intraarticular injections were very promising in short and long term. Pain decreased and mobility and stability of the osteoarthritic knee increased leading to a better quality of life 6 months after treatment, as shown in the VAS, KOOS and Lysholm scores. Two groups of cytokines showing high correlations were found, indicating that at least two separate sub-populations exist among early osteoarthritic patients, who may respond differently to serum therapy." @default.
- W4387053062 created "2023-09-27" @default.
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- W4387053062 date "2023-09-01" @default.
- W4387053062 modified "2023-09-27" @default.
- W4387053062 title "Clinical Effects And Cytokine Changes After Intraarticular Hyperacute Serum Injection In The Knee." @default.
- W4387053062 doi "https://doi.org/10.1249/01.mss.0000988696.50010.1d" @default.
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