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• W4387053729 abstract "Telomeres play a key role in the protection of chromosomes. A good index of biological aging is the length of telomeres. Telomeres gradually shorten over time. Hence, they are strongly related to chronological age. Lifestyle is also an important factor influencing telomere length. PURPOSE: This investigation was designed to study the relationship between 10-yr weight change and leukocyte telomere length (LTL) in a large sample of 3,059 randomly selected U.S. adults, 36-70 years old. METHODS: NHANES (National Health and Nutrition Examination Study) data were used with a cross-sectional design to examine the relationship between percent weight change and LTL. Percent weight change was calculated by subtracting body weight 10-yrs earlier from current body weight and then dividing by baseline weight. The quantitative polymerase chain reaction method was used to measure LTL relative to standard reference DNA (T/S ratio). Covariates included age, sex, race, assessment year, economic status, intent to lose weight, BMI, smoking, total physical activity, and disease status, (i.e., having or not having diabetes, cardiovascular disease, and/or cancer). Multiple regression was used to quantify the linear relationship between percent weight change and LTL. Potential mediating variables were controlled using partial correlation. Because women and men differed in percent 10-yr weight change and telomere length, data were analyzed separately by sex. RESULTS: After adjusting for age, race, year, and economic status, the association between percent 10-yr weight change and LTL was significant in women (F = 6.9, P = 0.0134). Controlling for all the covariates weakened the relationship slightly (F = 5.5, P = 0.0266). With all the covariates controlled, for each 1 percentage point increase in weight over the previous 10-yrs, telomeres were 3.6 base pairs (bp) shorter, on average. Given each 1-yr increase in age was associated with telomeres that were 12.6 bp shorter in women, each 10-percentage point increase in weight over the previous 10-yrs (the median) was predictive of LTL that were 36 bp shorter, on average, or an increase of 2.9 years of biological aging. 10-yr percent weight change was not associated with LTL in men. CONCLUSION: 10-yr weight change is a strong predictor of biological aging in U.S. women, but not in men." @default.
• W4387053729 created "2023-09-27" @default.
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• W4387053729 date "2023-09-01" @default.
• W4387053729 modified "2023-09-27" @default.
• W4387053729 title "10-year Weight Change Is Predictive Of Biological Aging In 3,059 U.S. Adults" @default.
• W4387053729 doi "https://doi.org/10.1249/01.mss.0000986960.33613.58" @default.
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