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• W4387054346 abstract "TNFα converting enzyme (TACE) cleaves membrane bound TNFα (mTNFα) to its soluble (sTNFα) and more bioactive form, has been linked to cardiovascular disease and insulin resistance. PURPOSE: to investigate the effect of aerobic exercise training and/or diet induced weight loss intervention on skeletal muscle TACE in overweight older adults. Based on previously published associational data, we hypothesized that exercise training and/or weight loss would decrease TACE expression in skeletal muscle of overweight, relatively unfit older adults. METHODS: Thirty-three overweight (BMI: 33 ± 0.6 mL/kg/min), older adults (age:63 ± 0.8y, VO2max: 16.3 mL/kg/min) were randomized into four groups: control (CON, N = 9), supervised aerobic exercise training (EX, N = 10), dietitian-guided, diet-induced weight loss (DIET, N = 8), and diet + aerobic exercise training (DEX, N = 6). The interventions lasted six months. TACE expression (via Western blot), body composition, and VO2max were measured pre and post intervention. Data were expressed as percent change from pre-intervention. Comparisons were made using ANOVA. RESULTS: Percent change in skeletal muscle TACE was significantly different (p < 0.05) between CON (+16.1 ± 13%) and EX (-39 ± 13%), but not DIET (-11 ± 18%) or DEX (-18 ± 18%). Percent change in body mass was significantly different (p < 0.05) between CON (+0.5 ± 1.2%) and DIET (-6.5 ± 1.8%) and DEX (-8.9 ± 2.4%), but not EX (-0.6 ± 0.9%). Percent change in VO2max was significantly different (p < 0.05) between CON (-7.4 ± 3.8%) and EX (+13.8 ± 10.9%) and DEX (+26.6 ± 8.9%), but not DIET (7.0 ± 7.3%). CONCLUSION: The exercise training and diet-induced weight loss interventions were successful in improving VO2max in EX and DEX, and decreasing body mass in DIET and DEX. While TACE expression decreased in each of our intervention groups, only EX was significantly different than CON. Supported by NIH Grant 1R15AG055923-01" @default.
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• W4387054346 date "2023-09-01" @default.
• W4387054346 modified "2023-09-27" @default.
• W4387054346 title "The Effect Of Exercise Training And Diet-induced Weight Loss On Skeletal Muscle Tnfα Converting Enzyme" @default.
• W4387054346 doi "https://doi.org/10.1249/01.mss.0000981812.87387.36" @default.
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