Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387056927> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W4387056927 abstract "DPP4 inhibitors are widely prescribed as treatments for type 2 diabetes. Because drug responses vary among individuals, we initiated investigations to identify genetic variants associated with the magnitude of drug responses.Sitagliptin (100 mg) was administered to 47 healthy volunteers. Several endpoints were measured to assess clinically relevant responses - including the effect of sitagliptin on glucose and insulin levels during an oral glucose tolerance test (OGTT).This pilot study confirmed that sitagliptin (100 mg) decreased the area under the curve for glucose during an OGTT (p=0.0003). Furthermore, sitagliptin promoted insulin secretion during the early portion of the OGTT as reflected by in increase in the ratio of plasma insulin at 60 min divided by plasma insulin at 30 min (T30:T60) from 0.87+/-0.05 to 1.62+/-0.36 mU/L (p=0.04). The magnitude of sitagliptin's effect on insulin secretion (as judged by the increase in the T30:T60 ratio for insulin) was correlated with the magnitude of sitagliptin-induced increase in the area under the curve for intact plasma GLP1 levels during the first hour of the OGTT. This study confirmed previously reported sex differences in glucose and insulin levels during an OGTT. Specifically, females exhibited higher levels of glucose and insulin at the 90-180 min time points. However, there did not appear to be significant differences in the magnitude of sitagliptin-induced changes in T30:T60 ratios for either glucose or insulin.T30:T60 ratios for insulin and glucose during an OGTT provide useful indices to assess pharmacodynamic responses to DPP4 inhibitors." @default.
- W4387056927 created "2023-09-27" @default.
- W4387056927 creator A5009070946 @default.
- W4387056927 creator A5012822170 @default.
- W4387056927 creator A5027947946 @default.
- W4387056927 creator A5036450244 @default.
- W4387056927 creator A5048709039 @default.
- W4387056927 creator A5064924632 @default.
- W4387056927 creator A5077733401 @default.
- W4387056927 creator A5079298837 @default.
- W4387056927 date "2023-09-25" @default.
- W4387056927 modified "2023-10-18" @default.
- W4387056927 title "Acute pharmacodynamic responses to sitagliptin: Drug-induced increase in early insulin secretion in oral glucose tolerance test." @default.
- W4387056927 cites W2003946536 @default.
- W4387056927 cites W2031007269 @default.
- W4387056927 cites W2043121816 @default.
- W4387056927 cites W2054185381 @default.
- W4387056927 cites W2111473023 @default.
- W4387056927 cites W2140369318 @default.
- W4387056927 cites W2160563455 @default.
- W4387056927 cites W2774119304 @default.
- W4387056927 cites W2945243267 @default.
- W4387056927 cites W2948561231 @default.
- W4387056927 cites W3036199105 @default.
- W4387056927 cites W3107469749 @default.
- W4387056927 cites W3122081836 @default.
- W4387056927 cites W4296702771 @default.
- W4387056927 cites W4296802076 @default.
- W4387056927 cites W4300862934 @default.
- W4387056927 cites W4327711424 @default.
- W4387056927 cites W4376225273 @default.
- W4387056927 cites W4379094066 @default.
- W4387056927 cites W4385798200 @default.
- W4387056927 doi "https://doi.org/10.1101/2023.09.24.23296026" @default.
- W4387056927 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37808823" @default.
- W4387056927 hasPublicationYear "2023" @default.
- W4387056927 type Work @default.
- W4387056927 citedByCount "0" @default.
- W4387056927 crossrefType "posted-content" @default.
- W4387056927 hasAuthorship W4387056927A5009070946 @default.
- W4387056927 hasAuthorship W4387056927A5012822170 @default.
- W4387056927 hasAuthorship W4387056927A5027947946 @default.
- W4387056927 hasAuthorship W4387056927A5036450244 @default.
- W4387056927 hasAuthorship W4387056927A5048709039 @default.
- W4387056927 hasAuthorship W4387056927A5064924632 @default.
- W4387056927 hasAuthorship W4387056927A5077733401 @default.
- W4387056927 hasAuthorship W4387056927A5079298837 @default.
- W4387056927 hasBestOaLocation W43870569271 @default.
- W4387056927 hasConcept C111113717 @default.
- W4387056927 hasConcept C112705442 @default.
- W4387056927 hasConcept C126322002 @default.
- W4387056927 hasConcept C134018914 @default.
- W4387056927 hasConcept C2777180221 @default.
- W4387056927 hasConcept C2777391703 @default.
- W4387056927 hasConcept C2778881409 @default.
- W4387056927 hasConcept C2779284873 @default.
- W4387056927 hasConcept C2779306644 @default.
- W4387056927 hasConcept C2780833929 @default.
- W4387056927 hasConcept C2910260750 @default.
- W4387056927 hasConcept C555293320 @default.
- W4387056927 hasConcept C71924100 @default.
- W4387056927 hasConceptScore W4387056927C111113717 @default.
- W4387056927 hasConceptScore W4387056927C112705442 @default.
- W4387056927 hasConceptScore W4387056927C126322002 @default.
- W4387056927 hasConceptScore W4387056927C134018914 @default.
- W4387056927 hasConceptScore W4387056927C2777180221 @default.
- W4387056927 hasConceptScore W4387056927C2777391703 @default.
- W4387056927 hasConceptScore W4387056927C2778881409 @default.
- W4387056927 hasConceptScore W4387056927C2779284873 @default.
- W4387056927 hasConceptScore W4387056927C2779306644 @default.
- W4387056927 hasConceptScore W4387056927C2780833929 @default.
- W4387056927 hasConceptScore W4387056927C2910260750 @default.
- W4387056927 hasConceptScore W4387056927C555293320 @default.
- W4387056927 hasConceptScore W4387056927C71924100 @default.
- W4387056927 hasLocation W43870569271 @default.
- W4387056927 hasLocation W43870569272 @default.
- W4387056927 hasOpenAccess W4387056927 @default.
- W4387056927 hasPrimaryLocation W43870569271 @default.
- W4387056927 hasRelatedWork W1526529090 @default.
- W4387056927 hasRelatedWork W1980451564 @default.
- W4387056927 hasRelatedWork W2002937262 @default.
- W4387056927 hasRelatedWork W2051462052 @default.
- W4387056927 hasRelatedWork W2080866420 @default.
- W4387056927 hasRelatedWork W2085862152 @default.
- W4387056927 hasRelatedWork W2122654440 @default.
- W4387056927 hasRelatedWork W2146850822 @default.
- W4387056927 hasRelatedWork W2797646286 @default.
- W4387056927 hasRelatedWork W3034408257 @default.
- W4387056927 isParatext "false" @default.
- W4387056927 isRetracted "false" @default.
- W4387056927 workType "article" @default.