Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387057546> ?p ?o ?g. }
- W4387057546 abstract "ABSTRACT Overlapping or convergent stress-activated molecular pathways exist to coordinate cell fate in response to stimuli such as hypoxia, oxidative stress, DNA damage, and unfolded proteins. Cells can remodel the splicing and translation machineries to mount a specialized gene expression response to certain stresses. Here, we show that hypoxic human cells in 2D and 3D culture models increase the relative abundance by 1.7- to 2.6-fold and 4.7- to 11.5-fold, respectively, of a longer mRNA variant of ribosomal protein S24 (RPS24L) compared to a shorter mRNA variant (RPS24S) by favoring the inclusion of a 22 bp cassette exon. Mechanistically, RPS24L and RPS24S are induced and repressed, respectively, by distinct parallel pathways in hypoxia: RPS24L is induced in an autophagy-dependent manner, while RPS24S is reduced by mTORC1 repression and in a HIF-dependent manner. RPS24L is a more stable mRNA in hypoxia and produces a more stable protein isoform compared to RPS24S. Cells overexpressing RPS24L display improved survival and growth in hypoxia relative to control cells and cells overexpressing RPS24S, which display impaired survival. Previous work from our group showed a correlation between RPS24L levels and tumor hypoxia in prostate cancer. These data highlight RPS24L as a stress-induced alternative splicing event that favors hypoxic cell survival, which could be exploited by cancer cells in the tumor microenvironment." @default.
- W4387057546 created "2023-09-27" @default.
- W4387057546 creator A5009335720 @default.
- W4387057546 creator A5016823222 @default.
- W4387057546 creator A5021908863 @default.
- W4387057546 creator A5075273267 @default.
- W4387057546 creator A5076605314 @default.
- W4387057546 creator A5078045222 @default.
- W4387057546 creator A5092945656 @default.
- W4387057546 creator A5092945657 @default.
- W4387057546 date "2023-09-25" @default.
- W4387057546 modified "2023-10-14" @default.
- W4387057546 title "Autophagy-dependent alternative splicing event produces a more stable ribosomal protein S24 isoform that aids in hypoxic cell survival" @default.
- W4387057546 cites W1561152519 @default.
- W4387057546 cites W1970838453 @default.
- W4387057546 cites W1981496699 @default.
- W4387057546 cites W2002636911 @default.
- W4387057546 cites W2003670869 @default.
- W4387057546 cites W2010386340 @default.
- W4387057546 cites W2010614742 @default.
- W4387057546 cites W2013932632 @default.
- W4387057546 cites W2019692639 @default.
- W4387057546 cites W2024334459 @default.
- W4387057546 cites W2026834042 @default.
- W4387057546 cites W2041144268 @default.
- W4387057546 cites W2042573239 @default.
- W4387057546 cites W2043882563 @default.
- W4387057546 cites W2056032938 @default.
- W4387057546 cites W2058312109 @default.
- W4387057546 cites W2060167034 @default.
- W4387057546 cites W2061473417 @default.
- W4387057546 cites W2066928298 @default.
- W4387057546 cites W2108086395 @default.
- W4387057546 cites W2112018328 @default.
- W4387057546 cites W2115021528 @default.
- W4387057546 cites W2115820946 @default.
- W4387057546 cites W2127063807 @default.
- W4387057546 cites W2128677683 @default.
- W4387057546 cites W2158535498 @default.
- W4387057546 cites W2264806126 @default.
- W4387057546 cites W2292986614 @default.
- W4387057546 cites W2312098803 @default.
- W4387057546 cites W2312506538 @default.
- W4387057546 cites W2527239283 @default.
- W4387057546 cites W2552872119 @default.
- W4387057546 cites W2557904026 @default.
- W4387057546 cites W2762658812 @default.
- W4387057546 cites W2762717139 @default.
- W4387057546 cites W2808848024 @default.
- W4387057546 cites W2909992178 @default.
- W4387057546 cites W2969931491 @default.
- W4387057546 cites W2981732241 @default.
- W4387057546 cites W2998930842 @default.
- W4387057546 cites W3003727514 @default.
- W4387057546 cites W3008346374 @default.
- W4387057546 cites W3034600147 @default.
- W4387057546 cites W4210730317 @default.
- W4387057546 cites W4293216102 @default.
- W4387057546 cites W4313446177 @default.
- W4387057546 cites W4313516466 @default.
- W4387057546 cites W4319827419 @default.
- W4387057546 doi "https://doi.org/10.1101/2023.09.25.559338" @default.
- W4387057546 hasPublicationYear "2023" @default.
- W4387057546 type Work @default.
- W4387057546 citedByCount "0" @default.
- W4387057546 crossrefType "posted-content" @default.
- W4387057546 hasAuthorship W4387057546A5009335720 @default.
- W4387057546 hasAuthorship W4387057546A5016823222 @default.
- W4387057546 hasAuthorship W4387057546A5021908863 @default.
- W4387057546 hasAuthorship W4387057546A5075273267 @default.
- W4387057546 hasAuthorship W4387057546A5076605314 @default.
- W4387057546 hasAuthorship W4387057546A5078045222 @default.
- W4387057546 hasAuthorship W4387057546A5092945656 @default.
- W4387057546 hasAuthorship W4387057546A5092945657 @default.
- W4387057546 hasBestOaLocation W43870575461 @default.
- W4387057546 hasConcept C104317684 @default.
- W4387057546 hasConcept C105580179 @default.
- W4387057546 hasConcept C143425029 @default.
- W4387057546 hasConcept C153911025 @default.
- W4387057546 hasConcept C178790620 @default.
- W4387057546 hasConcept C185592680 @default.
- W4387057546 hasConcept C190283241 @default.
- W4387057546 hasConcept C194583182 @default.
- W4387057546 hasConcept C203522944 @default.
- W4387057546 hasConcept C36823959 @default.
- W4387057546 hasConcept C38062823 @default.
- W4387057546 hasConcept C53345823 @default.
- W4387057546 hasConcept C540031477 @default.
- W4387057546 hasConcept C54355233 @default.
- W4387057546 hasConcept C54458228 @default.
- W4387057546 hasConcept C552990157 @default.
- W4387057546 hasConcept C62478195 @default.
- W4387057546 hasConcept C67705224 @default.
- W4387057546 hasConcept C7836513 @default.
- W4387057546 hasConcept C81885089 @default.
- W4387057546 hasConcept C86554907 @default.
- W4387057546 hasConcept C86803240 @default.
- W4387057546 hasConcept C88478588 @default.
- W4387057546 hasConcept C95444343 @default.
- W4387057546 hasConcept C98490376 @default.