Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387059199> ?p ?o ?g. }
- W4387059199 endingPage "14543" @default.
- W4387059199 startingPage "14543" @default.
- W4387059199 abstract "Breast cancer (BC) is one of the biggest health problems worldwide, characterized by intricate metabolic and biochemical complexities stemming from pronounced variations across dysregulated molecular pathways. If BC is not diagnosed early, complications may lead to death. Thus, the pursuit of novel therapeutic avenues persists, notably focusing on epigenetic pathways such as histone deacetylases (HDACs). The compound N-(2-hydroxyphenyl)-2-propylpentanamide (HO-AAVPA), a derivative of valproic acid (VPA), has emerged as a promising candidate warranting pre-clinical investigation. HO-AAVPA is an HDAC inhibitor with antiproliferative effects on BC, but its molecular mechanism has yet to be deciphered. Furthermore, in the present study, we determined the metabolomic effects of HO-AAVPA and VPA on cells of luminal breast cancer (MCF-7) and triple-negative breast cancer (MDA-MB-231) subtypes. The LC-MS untargeted metabolomic study allowed for the simultaneous measurement of multiple metabolites and pathways, identifying that both compounds affect glycerophospholipid and sphingolipid metabolism in the MCF-7 and MDA-MB-231 cell lines, suggesting that other biological targets were different from HDACs. In addition, there are different dysregulate metabolites, possibly due to the physicochemical differences between HO-AAVPA and VPA." @default.
- W4387059199 created "2023-09-27" @default.
- W4387059199 creator A5009535929 @default.
- W4387059199 creator A5046638873 @default.
- W4387059199 creator A5054136264 @default.
- W4387059199 creator A5070296386 @default.
- W4387059199 creator A5072377320 @default.
- W4387059199 creator A5075929981 @default.
- W4387059199 date "2023-09-26" @default.
- W4387059199 modified "2023-10-17" @default.
- W4387059199 title "Untargeted LC-MS/MS Metabolomics Study of HO-AAVPA and VPA on Breast Cancer Cell Lines" @default.
- W4387059199 cites W1831272119 @default.
- W4387059199 cites W1862292403 @default.
- W4387059199 cites W1968076212 @default.
- W4387059199 cites W1970210902 @default.
- W4387059199 cites W1971606140 @default.
- W4387059199 cites W1971621147 @default.
- W4387059199 cites W1972149587 @default.
- W4387059199 cites W1973348591 @default.
- W4387059199 cites W1976327004 @default.
- W4387059199 cites W1995900324 @default.
- W4387059199 cites W1999316749 @default.
- W4387059199 cites W2015159011 @default.
- W4387059199 cites W2025701648 @default.
- W4387059199 cites W2037679360 @default.
- W4387059199 cites W2042889901 @default.
- W4387059199 cites W2055158339 @default.
- W4387059199 cites W2056901945 @default.
- W4387059199 cites W2070652529 @default.
- W4387059199 cites W2071559249 @default.
- W4387059199 cites W2088666810 @default.
- W4387059199 cites W2115593774 @default.
- W4387059199 cites W2124196964 @default.
- W4387059199 cites W2124855293 @default.
- W4387059199 cites W2142856784 @default.
- W4387059199 cites W2167540852 @default.
- W4387059199 cites W2197271423 @default.
- W4387059199 cites W2295182096 @default.
- W4387059199 cites W2415247663 @default.
- W4387059199 cites W2475853404 @default.
- W4387059199 cites W2494284414 @default.
- W4387059199 cites W2511667040 @default.
- W4387059199 cites W2520784563 @default.
- W4387059199 cites W2530515030 @default.
- W4387059199 cites W2565873626 @default.
- W4387059199 cites W2724336500 @default.
- W4387059199 cites W2744970765 @default.
- W4387059199 cites W2756562465 @default.
- W4387059199 cites W2774922710 @default.
- W4387059199 cites W2775295060 @default.
- W4387059199 cites W2790234382 @default.
- W4387059199 cites W2795612666 @default.
- W4387059199 cites W2802842185 @default.
- W4387059199 cites W2805590406 @default.
- W4387059199 cites W2890007217 @default.
- W4387059199 cites W2891747284 @default.
- W4387059199 cites W2900545456 @default.
- W4387059199 cites W2901627401 @default.
- W4387059199 cites W2912993657 @default.
- W4387059199 cites W2913467766 @default.
- W4387059199 cites W2946284425 @default.
- W4387059199 cites W2952752961 @default.
- W4387059199 cites W2963386271 @default.
- W4387059199 cites W2974361058 @default.
- W4387059199 cites W2992324722 @default.
- W4387059199 cites W3008673110 @default.
- W4387059199 cites W3012149251 @default.
- W4387059199 cites W3016613456 @default.
- W4387059199 cites W3022228983 @default.
- W4387059199 cites W3049235536 @default.
- W4387059199 cites W3120949185 @default.
- W4387059199 cites W3121448169 @default.
- W4387059199 cites W3128646645 @default.
- W4387059199 cites W3152234698 @default.
- W4387059199 cites W3158660301 @default.
- W4387059199 cites W3159995035 @default.
- W4387059199 cites W3163466446 @default.
- W4387059199 cites W3183381955 @default.
- W4387059199 cites W3207668409 @default.
- W4387059199 cites W3207713111 @default.
- W4387059199 cites W4206447491 @default.
- W4387059199 cites W4214607379 @default.
- W4387059199 cites W4225529913 @default.
- W4387059199 cites W4250269528 @default.
- W4387059199 cites W4283017342 @default.
- W4387059199 cites W4285394750 @default.
- W4387059199 cites W4304587345 @default.
- W4387059199 cites W4306153355 @default.
- W4387059199 cites W4310672670 @default.
- W4387059199 cites W4322765913 @default.
- W4387059199 doi "https://doi.org/10.3390/ijms241914543" @default.
- W4387059199 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37833990" @default.
- W4387059199 hasPublicationYear "2023" @default.
- W4387059199 type Work @default.
- W4387059199 citedByCount "0" @default.
- W4387059199 crossrefType "journal-article" @default.
- W4387059199 hasAuthorship W4387059199A5009535929 @default.
- W4387059199 hasAuthorship W4387059199A5046638873 @default.