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- W4387062334 abstract "Advancing age is associated with changes to skeletal muscle size, function, and metabolism. However, our understanding of the molecular factors that contribute to these changes are not fully understood. PURPOSE: To identify relevant biological processes that are associated with downregulated genes in the skeletal muscle of older adults. METHODS: Skeletal muscle biopsy samples (vastus lateralis) were analyzed from healthy younger (27 ± 3 yr; 8 M, 1F; BMI: 24.5 ± 2.0) and older adults (68 ± 5 yr; 6 M, 3F; BMI: 25.9 ± 4.7 kg•m-2). Muscle biopsies were obtained under resting conditions, after an overnight fast, and controlling for previous physical activity. Whole transcriptome bulk RNA sequencing (HISeq2500, Illumina) was performed on cDNA synthesized from isolated RNA. Differential gene expression between younger and older adults was identified (with young as reference) using an adjusted p-value of <0.1 for comparisons between young and old. RESULTS: 20,810 genes were identified among all samples, from which 786 genes were considered to be downregulated in the skeletal muscle of older adults. From analyses using only these downregulated genes, we identified 136 associated biological processes, most notably biological processes related to protein ubiquitination and glucose metabolism. Interestingly, aspects related to glucose/glycogen metabolism were also identified using cellular compartment and KEGG pathway analyses. The gene PHKA1, which encodes for the alpha subunit of phosphorylase b kinase, was identified as a top downregulated gene. CONCLUSION: These data highlight that future research aimed to identify molecular/biological processes associated with age-related declines in skeletal muscle function may consider examination of glucose/glycogen metabolic processes." @default.
- W4387062334 created "2023-09-27" @default.
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- W4387062334 date "2023-09-01" @default.
- W4387062334 modified "2023-09-27" @default.
- W4387062334 title "Aging Is Associated With Downregulation Of Genes Linked To Glucose Metabolism In Human Skeletal Muscle" @default.
- W4387062334 doi "https://doi.org/10.1249/01.mss.0000981720.19080.b6" @default.
- W4387062334 hasPublicationYear "2023" @default.
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