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- W4387063219 abstract "Sex differences in inflammatory responses and cardiovascular disease rates persist across the life span. Inflammation is one of the major causes of vascular dysfunction leading to cardiovascular disease. A high-fat meal (HFM) can be used as a model to induce acute inflammation. Previous literature has shown sex differences in vascular function following a HFM, however, it is currently unknown if sex differences persist in measures of arterial stiffness and wave reflection following a HFM in young, healthy adults. PURPOSE: To elucidate whether there are sex differences in arterial stiffness and wave reflection responses to a HFM in a young, healthy population. METHODS: Augmentation index (AIx; %), augmentation index standardized to a heart rate of 75 bpm (AIx75; %), and carotid-femoral pulse wave velocity (cfPWV; m/s) were measured at baseline (BL) and 4 hours-post HFM (4HP) in eight women (26 ± 4 y) and twelve men (22 ± 3 y). RESULTS: AIx, AIx75, and cfPWV remained unchanged in both men (AIx BL: -1.25 ± 4.73% vs. AIx 4HP: -5.33 ± 6.99%; AIx75 BL: -10.83 ± 5.15% vs AIx75 4HP: -12.58 ± 7.39%; cfPWV BL: 5.34 ± 0.77 m/s vs. cfPWV 4HP: 5.66 ± 0.67 m/s, n = 11) and women (AIx BL: 3.25 ± 8.81% vs. AIx 4HP: -5.43 ± 13.86% (n = 7); AIx75 BL: -6.50 ± 11.92% vs. AIx75 4HP: -11.57 ± 10.74% (n = 7); cfPWV BL: 5.36 ± 0.89 m/s vs. cfPWV 4HP: 5.44 ± 0.78 m/s) following the HFM. There were no significant model effects or interaction between time and sex for AIx (F (1, 35) = 0.6864, p = 0.41), AIx75 (F (1, 35) = 0.3446, p = 0.56), or cfPWV (F (1, 35) = 0.1803, p = 0.67). CONCLUSIONS: Arterial stiffness and wave reflection responses are similar in young, healthy men and women following a HFM. Supported by MPower (University of Maryland)" @default.
- W4387063219 created "2023-09-27" @default.
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- W4387063219 date "2023-09-01" @default.
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- W4387063219 title "Men And Women Have Similar Responses In Arterial Stiffness And Wave Reflection Post-High-Fat Meal" @default.
- W4387063219 doi "https://doi.org/10.1249/01.mss.0000979756.30419.3b" @default.
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