FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387063556> ?p ?o ?g. }

• W4387063556 endingPage "122129" @default.
• W4387063556 startingPage "122129" @default.
• W4387063556 abstract "Ecto-5'-nucleotidase (CD73), encoded by the NT5E gene, mediates tumor immunosuppression and has been targeted for the development of new anticancer drugs. Proteasome inhibitors impair protein degradation by inhibiting proteasome and have been used in the clinic for cancer therapy. Here we report that proteasome inhibitors reduce the protein and mRNA levels of CD73. Among 127 tested small-molecule drugs, proteasome inhibitors were found to consistently decrease the protein and mRNA levels of CD73 in NSCLC NCI-H1299 cells. This effect was further confirmed in different NSCLC cells exposed to different proteasome inhibitors. In those treated cells, the protein levels of ERK and its active form p-ERK, the vital components in the MAPK pathway, were reduced. Consistently, inhibitors of MEK and ERK, another two members of the MAPK pathway, also lowered the protein and mRNA levels of CD73. Correspondingly, treatments with fibroblast growth factor 2 (FGF2), an activator of the MAPK pathway, enhanced the levels of p-ERK and partly rescued the proteasome inhibitor-driven reduction of CD73 mRNA and protein in NSCLC cells. However, exogenous CD73 overexpression in murine Lewis lung carcinoma (LLC) cells was not lowered either in vitro or in vivo, by the treatments with proteasome inhibitors and basically, did not affect their in vitro proliferative inhibition either. In contrast, CD73 overexpression dramatically reduced the in vivo anticancer activity of Bortezomib in immunocompetent mice, with tumor growth inhibition rates from 52.18 % for LLC/vector down to 8.75 % for LLC/NT5E homografts. These findings give new insights into the anticancer mechanisms of proteasome inhibitors." @default.
• W4387063556 created "2023-09-27" @default.
• W4387063556 creator A5005260665 @default.
• W4387063556 creator A5013917173 @default.
• W4387063556 creator A5022124964 @default.
• W4387063556 creator A5047491476 @default.
• W4387063556 creator A5053802610 @default.
• W4387063556 creator A5059309364 @default.
• W4387063556 creator A5086754083 @default.
• W4387063556 date "2023-11-01" @default.
• W4387063556 modified "2023-10-15" @default.
• W4387063556 title "Proteasome inhibitors reduce CD73 expression partly via decreasing p-ERK in NSCLC cells" @default.
• W4387063556 cites W1568069191 @default.
• W4387063556 cites W2005133489 @default.
• W4387063556 cites W2032065009 @default.
• W4387063556 cites W2035446838 @default.
• W4387063556 cites W2043291701 @default.
• W4387063556 cites W2044455815 @default.
• W4387063556 cites W2062371653 @default.
• W4387063556 cites W2064037082 @default.
• W4387063556 cites W2064498246 @default.
• W4387063556 cites W2080513978 @default.
• W4387063556 cites W2140765540 @default.
• W4387063556 cites W2144169031 @default.
• W4387063556 cites W2165400873 @default.
• W4387063556 cites W2600984276 @default.
• W4387063556 cites W2605136479 @default.
• W4387063556 cites W2605835842 @default.
• W4387063556 cites W2753741461 @default.
• W4387063556 cites W2761491777 @default.
• W4387063556 cites W2769890142 @default.
• W4387063556 cites W2798115114 @default.
• W4387063556 cites W2804816658 @default.
• W4387063556 cites W2890392576 @default.
• W4387063556 cites W2916314647 @default.
• W4387063556 cites W2916518076 @default.
• W4387063556 cites W2964199936 @default.
• W4387063556 cites W2990651874 @default.
• W4387063556 cites W3003893645 @default.
• W4387063556 cites W3041798570 @default.
• W4387063556 cites W3047301878 @default.
• W4387063556 cites W3091909456 @default.
• W4387063556 cites W3094319235 @default.
• W4387063556 cites W3126945948 @default.
• W4387063556 cites W3133023059 @default.
• W4387063556 cites W3134511527 @default.
• W4387063556 cites W3158627227 @default.
• W4387063556 cites W3196262155 @default.
• W4387063556 cites W3201569462 @default.
• W4387063556 cites W3202861577 @default.
• W4387063556 cites W3212818071 @default.
• W4387063556 cites W4206929088 @default.
• W4387063556 cites W4206934794 @default.
• W4387063556 cites W4220680369 @default.
• W4387063556 cites W4220955609 @default.
• W4387063556 cites W4221011919 @default.
• W4387063556 cites W4226207639 @default.
• W4387063556 cites W4229335110 @default.
• W4387063556 cites W4250417345 @default.
• W4387063556 cites W4281568158 @default.
• W4387063556 cites W4289638504 @default.
• W4387063556 cites W4293104691 @default.
• W4387063556 cites W4296793858 @default.
• W4387063556 cites W4308548730 @default.
• W4387063556 cites W4321749000 @default.
• W4387063556 doi "https://doi.org/10.1016/j.lfs.2023.122129" @default.
• W4387063556 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37769804" @default.
• W4387063556 hasPublicationYear "2023" @default.
• W4387063556 type Work @default.
• W4387063556 citedByCount "0" @default.
• W4387063556 crossrefType "journal-article" @default.
• W4387063556 hasAuthorship W4387063556A5005260665 @default.
• W4387063556 hasAuthorship W4387063556A5013917173 @default.
• W4387063556 hasAuthorship W4387063556A5022124964 @default.
• W4387063556 hasAuthorship W4387063556A5047491476 @default.
• W4387063556 hasAuthorship W4387063556A5053802610 @default.
• W4387063556 hasAuthorship W4387063556A5059309364 @default.
• W4387063556 hasAuthorship W4387063556A5086754083 @default.
• W4387063556 hasConcept C11960822 @default.
• W4387063556 hasConcept C121608353 @default.
• W4387063556 hasConcept C150903083 @default.
• W4387063556 hasConcept C185592680 @default.
• W4387063556 hasConcept C202751555 @default.
• W4387063556 hasConcept C203014093 @default.
• W4387063556 hasConcept C207001950 @default.
• W4387063556 hasConcept C27740335 @default.
• W4387063556 hasConcept C2776364478 @default.
• W4387063556 hasConcept C2777478702 @default.
• W4387063556 hasConcept C2777847059 @default.
• W4387063556 hasConcept C2778367456 @default.
• W4387063556 hasConcept C2779013556 @default.
• W4387063556 hasConcept C502942594 @default.
• W4387063556 hasConcept C54355233 @default.
• W4387063556 hasConcept C55493867 @default.
• W4387063556 hasConcept C57074206 @default.
• W4387063556 hasConcept C86803240 @default.
• W4387063556 hasConcept C95444343 @default.
• W4387063556 hasConcept C98274493 @default.

• next