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- W4387068900 abstract "Complete cicatricial closure of the ostium is one of the common causes of a failed DCR [1–3]. The precise nasal mucosal wound healing is unclear. However, human models of wound healing have shown four distinct phases: the first phase (7–12 days) of wound enveloping by blood crusts, the second phase (2–4 weeks) of granulation tissue formation, the third phase (4–8 weeks) of tissue edema, and the fourth phase (12–14 weeks) of macroscopic normalization. Tissues from complete cicatricial closures of the DCR ostia, analyzed by electron microscopy, showed irregular laying of collagen in bundles with numerous intervening fibroblasts and mononuclear lymphocytic infiltrates (immunophenotyping showed them to be CD3+, CD5+, and CD20+ essentially reflecting mixed T and B lymphocytes) [3]. Amorphous bony osteoid was noted in the fibrillary background with numerous metabolically active osteoblasts. These osteoblasts showed hyper-proliferative mitochondria, large Golgi apparatus, and dense endoplasmic reticulum [3]. There is ample evidence of new bone formation within the scarred DCR tissues, which may open newer avenues in understanding the wound healing patterns and possible adjunctive pharmacotherapies." @default.
- W4387068900 created "2023-09-27" @default.
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- W4387068900 date "2023-01-01" @default.
- W4387068900 modified "2023-09-27" @default.
- W4387068900 title "The Dacryocystorhinostomy Ostium Cicatrix" @default.
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- W4387068900 doi "https://doi.org/10.1007/978-981-99-1401-2_71-1" @default.
- W4387068900 hasPublicationYear "2023" @default.
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