Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387078039> ?p ?o ?g. }
- W4387078039 abstract "Abstract Purpose As a member of the ubiquitin‐conjugating enzyme (E2) family, UBE2V2 demonstrates significant tumorigenicity in many cancers. However, the relationship between UBE2V2 expression and the morbidity of lung adenocarcinoma (LUAD) is still unknown. Methods We detected the mRNA and protein expression of UBE2V2 and analyzed its relationship with clinical parameters as well as survival prognosis based on bioinformatic and immunohistochemistry (IHC) in LUAD. The signaling pathway of UBE2V2 in the development of LUAD was obtained by GSEA. The TIMER database was used to investigate the association between UBE2V2 expression and the level of infiltration of different immune cells. Finally, we explored the effects of UBE2V2 knockdown on the proliferation, apoptosis, and migration of LUAD cells. Results The results showed that UBE2V2 was a potential oncogene and might be considered an independent prognostic molecule for LUAD patients based on TCGA prediction (HR: 1.497 p = 0.012) and IHC (HR:1.864 p = 0.044). IHC showed that UBE2V2 was related to the following clinicopathological factors: gender ( p = 0.043), stage ( p = 0.042), and lymph node metastasis ( p = 0.002). Finally, knockdown of UBE2V2 reduced the migration of LUAD cells by regulating EMT‐related proteins. Knockdown of UBE2V2 induced LUAD cells to arrest in the G1 phase. Knockdown of UBE2V2 increased LUAD cell apoptosis and decreased proliferation, which might be related to the downregulation of PCNA and upregulation of P53 and ƳH2AX expression. Interestingly, UBE2V2 is negatively correlated with B cells, CD4+ T cells, macrophages, and dendritic cells. Conclusion UBE2V2 may be a valuable therapeutic target for lung cancer." @default.
- W4387078039 created "2023-09-28" @default.
- W4387078039 creator A5022193491 @default.
- W4387078039 creator A5034653353 @default.
- W4387078039 creator A5046941806 @default.
- W4387078039 creator A5063335890 @default.
- W4387078039 creator A5086672406 @default.
- W4387078039 creator A5087325483 @default.
- W4387078039 date "2023-09-27" @default.
- W4387078039 modified "2023-09-28" @default.
- W4387078039 title "<scp>UBE2V2</scp> promotes metastasis by regulating <scp>EMT</scp> and predicts a poor prognosis in lung adenocarcinoma" @default.
- W4387078039 cites W1525117983 @default.
- W4387078039 cites W1965923359 @default.
- W4387078039 cites W1967827870 @default.
- W4387078039 cites W1974666401 @default.
- W4387078039 cites W1983441877 @default.
- W4387078039 cites W1988617344 @default.
- W4387078039 cites W2011338138 @default.
- W4387078039 cites W2042062849 @default.
- W4387078039 cites W2042386784 @default.
- W4387078039 cites W2042939784 @default.
- W4387078039 cites W2043157255 @default.
- W4387078039 cites W2054918042 @default.
- W4387078039 cites W2055124781 @default.
- W4387078039 cites W2058680827 @default.
- W4387078039 cites W2061580741 @default.
- W4387078039 cites W2076712649 @default.
- W4387078039 cites W2097096572 @default.
- W4387078039 cites W2101101375 @default.
- W4387078039 cites W2115182182 @default.
- W4387078039 cites W2126435004 @default.
- W4387078039 cites W2130410032 @default.
- W4387078039 cites W2131424666 @default.
- W4387078039 cites W2133819225 @default.
- W4387078039 cites W2134320577 @default.
- W4387078039 cites W2135631135 @default.
- W4387078039 cites W2136128861 @default.
- W4387078039 cites W2147268908 @default.
- W4387078039 cites W2148473493 @default.
- W4387078039 cites W2477961080 @default.
- W4387078039 cites W2890810370 @default.
- W4387078039 cites W2911188335 @default.
- W4387078039 cites W3195166887 @default.
- W4387078039 doi "https://doi.org/10.1002/cam4.6566" @default.
- W4387078039 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37755128" @default.
- W4387078039 hasPublicationYear "2023" @default.
- W4387078039 type Work @default.
- W4387078039 citedByCount "0" @default.
- W4387078039 crossrefType "journal-article" @default.
- W4387078039 hasAuthorship W4387078039A5022193491 @default.
- W4387078039 hasAuthorship W4387078039A5034653353 @default.
- W4387078039 hasAuthorship W4387078039A5046941806 @default.
- W4387078039 hasAuthorship W4387078039A5063335890 @default.
- W4387078039 hasAuthorship W4387078039A5086672406 @default.
- W4387078039 hasAuthorship W4387078039A5087325483 @default.
- W4387078039 hasBestOaLocation W43870780391 @default.
- W4387078039 hasConcept C104317684 @default.
- W4387078039 hasConcept C121608353 @default.
- W4387078039 hasConcept C126322002 @default.
- W4387078039 hasConcept C127561419 @default.
- W4387078039 hasConcept C173396325 @default.
- W4387078039 hasConcept C190283241 @default.
- W4387078039 hasConcept C204232928 @default.
- W4387078039 hasConcept C2779013556 @default.
- W4387078039 hasConcept C2781018059 @default.
- W4387078039 hasConcept C2781182431 @default.
- W4387078039 hasConcept C29537977 @default.
- W4387078039 hasConcept C502942594 @default.
- W4387078039 hasConcept C54355233 @default.
- W4387078039 hasConcept C55493867 @default.
- W4387078039 hasConcept C62112901 @default.
- W4387078039 hasConcept C71924100 @default.
- W4387078039 hasConcept C86803240 @default.
- W4387078039 hasConceptScore W4387078039C104317684 @default.
- W4387078039 hasConceptScore W4387078039C121608353 @default.
- W4387078039 hasConceptScore W4387078039C126322002 @default.
- W4387078039 hasConceptScore W4387078039C127561419 @default.
- W4387078039 hasConceptScore W4387078039C173396325 @default.
- W4387078039 hasConceptScore W4387078039C190283241 @default.
- W4387078039 hasConceptScore W4387078039C204232928 @default.
- W4387078039 hasConceptScore W4387078039C2779013556 @default.
- W4387078039 hasConceptScore W4387078039C2781018059 @default.
- W4387078039 hasConceptScore W4387078039C2781182431 @default.
- W4387078039 hasConceptScore W4387078039C29537977 @default.
- W4387078039 hasConceptScore W4387078039C502942594 @default.
- W4387078039 hasConceptScore W4387078039C54355233 @default.
- W4387078039 hasConceptScore W4387078039C55493867 @default.
- W4387078039 hasConceptScore W4387078039C62112901 @default.
- W4387078039 hasConceptScore W4387078039C71924100 @default.
- W4387078039 hasConceptScore W4387078039C86803240 @default.
- W4387078039 hasLocation W43870780391 @default.
- W4387078039 hasLocation W43870780392 @default.
- W4387078039 hasOpenAccess W4387078039 @default.
- W4387078039 hasPrimaryLocation W43870780391 @default.
- W4387078039 hasRelatedWork W2048225838 @default.
- W4387078039 hasRelatedWork W2150002449 @default.
- W4387078039 hasRelatedWork W2354760635 @default.
- W4387078039 hasRelatedWork W2379203010 @default.
- W4387078039 hasRelatedWork W2494327966 @default.
- W4387078039 hasRelatedWork W2562103693 @default.