FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387078158> ?p ?o ?g. }

• W4387078158 abstract "Circulating tumor human papillomavirus DNA (ctHPVDNA) testing using digital-droplet polymerase chain reaction (PCR) detects fragments of tumor-modified human papillomavirus (HPV) in the plasma of patients with HPV-associated head and neck squamous cell carcinomas (HNSCCs). Its impact on tumor surveillance and primary diagnosis is limited by unresolved issues relating to sensitivity and specificity. The study population consisted of patients with HNSCC who had undergone ctHPVDNA testing. HPV status was determined by p16 immunohistochemistry and PCR-HPV genotyping on the tumor samples. For discrepant cases (HPV-positive/ctHPVDNA-negative), HPV status was confirmed by RNA in situ hybridization and, when possible, targeted single-nucleotide polymorphisms genotyping. A total of 167 patients had ctHPVDNA testing, and 141 tumors were HPV positive by p16 immunohistochemistry and PCR genotyping. Genotypes included types 16 (91.5%), 33 (4.3%), 35 (2.1%), and 18 (2.1%). ctHPVDNA was detected in 133 (94.3%) of HPV-positive HNSCCs but in none of the HPV-negative HNSCCs. Four of the 5 p16-positive cases that were negative by PCR and ctHPVDNA were positive by RNA in situ hybridization, and in 2 of these cases, rare high-risk genotypes were identified. ctHPVDNA had a sensitivity of 91.7%, specificity of 100%, positive predictive value of 100%, and negative predictive value of 63.6%. The likelihood that patients with HPV-positive HNSCC have detectable ctHPVDNA is high. Non-HPV16 genotypes contribute to discrepancies but only in a small subset of cases. This finding validates ongoing efforts to use ctHPVDNA as a surveillance tool, and even as a primary diagnostic assay in patients presenting with masses in the neck and/or oropharynx." @default.
• W4387078158 created "2023-09-28" @default.
• W4387078158 creator A5021281217 @default.
• W4387078158 creator A5038821505 @default.
• W4387078158 creator A5073960875 @default.
• W4387078158 creator A5074974316 @default.
• W4387078158 creator A5082904020 @default.
• W4387078158 creator A5086088557 @default.
• W4387078158 creator A5090322942 @default.
• W4387078158 date "2023-09-27" @default.
• W4387078158 modified "2023-09-28" @default.
• W4387078158 title "Circulating Tumor HPV DNA in Patients With Head and Neck Carcinoma" @default.
• W4387078158 cites W1579431979 @default.
• W4387078158 cites W1963790191 @default.
• W4387078158 cites W1968108709 @default.
• W4387078158 cites W1977050197 @default.
• W4387078158 cites W1981646010 @default.
• W4387078158 cites W1986141893 @default.
• W4387078158 cites W1987350137 @default.
• W4387078158 cites W2046912879 @default.
• W4387078158 cites W2086354412 @default.
• W4387078158 cites W2110664940 @default.
• W4387078158 cites W2149166037 @default.
• W4387078158 cites W2549938661 @default.
• W4387078158 cites W2742681205 @default.
• W4387078158 cites W2779288253 @default.
• W4387078158 cites W2918082188 @default.
• W4387078158 cites W2945478948 @default.
• W4387078158 cites W2990162690 @default.
• W4387078158 cites W3004553637 @default.
• W4387078158 cites W3036135178 @default.
• W4387078158 cites W3110035666 @default.
• W4387078158 cites W3211020881 @default.
• W4387078158 cites W4210889410 @default.
• W4387078158 cites W4211090013 @default.
• W4387078158 cites W4220818298 @default.
• W4387078158 cites W4221101481 @default.
• W4387078158 cites W4221128138 @default.
• W4387078158 cites W4226151440 @default.
• W4387078158 cites W4280573020 @default.
• W4387078158 cites W4307425596 @default.
• W4387078158 doi "https://doi.org/10.1097/pas.0000000000002134" @default.
• W4387078158 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37753709" @default.
• W4387078158 hasPublicationYear "2023" @default.
• W4387078158 type Work @default.
• W4387078158 citedByCount "0" @default.
• W4387078158 crossrefType "journal-article" @default.
• W4387078158 hasAuthorship W4387078158A5021281217 @default.
• W4387078158 hasAuthorship W4387078158A5038821505 @default.
• W4387078158 hasAuthorship W4387078158A5073960875 @default.
• W4387078158 hasAuthorship W4387078158A5074974316 @default.
• W4387078158 hasAuthorship W4387078158A5082904020 @default.
• W4387078158 hasAuthorship W4387078158A5086088557 @default.
• W4387078158 hasAuthorship W4387078158A5090322942 @default.
• W4387078158 hasConcept C104317684 @default.
• W4387078158 hasConcept C121608353 @default.
• W4387078158 hasConcept C126322002 @default.
• W4387078158 hasConcept C135763542 @default.
• W4387078158 hasConcept C142724271 @default.
• W4387078158 hasConcept C143998085 @default.
• W4387078158 hasConcept C150194340 @default.
• W4387078158 hasConcept C204232928 @default.
• W4387078158 hasConcept C2776530083 @default.
• W4387078158 hasConcept C2776833033 @default.
• W4387078158 hasConcept C2908647359 @default.
• W4387078158 hasConcept C2994532551 @default.
• W4387078158 hasConcept C31467283 @default.
• W4387078158 hasConcept C49105822 @default.
• W4387078158 hasConcept C54355233 @default.
• W4387078158 hasConcept C71924100 @default.
• W4387078158 hasConcept C81439078 @default.
• W4387078158 hasConcept C86803240 @default.
• W4387078158 hasConcept C99454951 @default.
• W4387078158 hasConceptScore W4387078158C104317684 @default.
• W4387078158 hasConceptScore W4387078158C121608353 @default.
• W4387078158 hasConceptScore W4387078158C126322002 @default.
• W4387078158 hasConceptScore W4387078158C135763542 @default.
• W4387078158 hasConceptScore W4387078158C142724271 @default.
• W4387078158 hasConceptScore W4387078158C143998085 @default.
• W4387078158 hasConceptScore W4387078158C150194340 @default.
• W4387078158 hasConceptScore W4387078158C204232928 @default.
• W4387078158 hasConceptScore W4387078158C2776530083 @default.
• W4387078158 hasConceptScore W4387078158C2776833033 @default.
• W4387078158 hasConceptScore W4387078158C2908647359 @default.
• W4387078158 hasConceptScore W4387078158C2994532551 @default.
• W4387078158 hasConceptScore W4387078158C31467283 @default.
• W4387078158 hasConceptScore W4387078158C49105822 @default.
• W4387078158 hasConceptScore W4387078158C54355233 @default.
• W4387078158 hasConceptScore W4387078158C71924100 @default.
• W4387078158 hasConceptScore W4387078158C81439078 @default.
• W4387078158 hasConceptScore W4387078158C86803240 @default.
• W4387078158 hasConceptScore W4387078158C99454951 @default.
• W4387078158 hasLocation W43870781581 @default.
• W4387078158 hasLocation W43870781582 @default.
• W4387078158 hasOpenAccess W4387078158 @default.
• W4387078158 hasPrimaryLocation W43870781581 @default.
• W4387078158 hasRelatedWork W1987790506 @default.
• W4387078158 hasRelatedWork W2022491072 @default.
• W4387078158 hasRelatedWork W2051586631 @default.
• W4387078158 hasRelatedWork W2055972548 @default.

• next