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- W4387078162 abstract "ABSTRACTIntroduction Liver X receptors (LXRs) have emerged as novel targets for tumor treatment. LXRs within the tumor microenvironment show the capacity to impact tumorigenesis and tumor development by regulating the infiltration of immune cells and release of cytokines to moderate inflammation.Areas covered In this review, we present a systematic description of recent progress in understanding the impact of LXRs on the tumor microenvironment and tumorigenesis. We also summarize the antitumor effects mediated by LXRs via their regulation of cytokine expression. Additionally, we discuss the limitations of LXR research in tumor studies to date.Expert opinion Previous studies have demonstrated abnormal LXR expression in tumor tissues, and activation of LXRs has been shown to inhibit tumorigenesis and promote apoptosis in tumor cells. However, LXRs can also affect tumorigenesis by regulating immune cell functions within the tumor immune microenvironment. By summarizing the impact of LXRs on immune cells, we provide new insights into the multifaceted nature of LXRs as antitumor targets.KEYWORDS: Liver X receptorCancertumor microenvironmentimmune cellCytokineinflammationDisclaimerAs a service to authors and researchers we are providing this version of an accepted manuscript (AM). Copyediting, typesetting, and review of the resulting proofs will be undertaken on this manuscript before final publication of the Version of Record (VoR). During production and pre-press, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal relate to these versions also. Article highlightsLXRs are de-orphanized members of the nuclear receptor superfamily. They play an important role in the regulation of various physiological activities, including cholesterol, metabolism fat formation, and inflammation.LXRs have been identified as targets for tumor therapy, acting on tumor cells, and also exerting anti-tumor effects in the tumor microenvironment.LXR affects the proliferation and differentiation of various immune cells.LXR also regulate the expression of multiple cytokines.LXR modulates immune cell-related metabolic pathways, thereby impacting tumorigenesis and development.Declaration of interestThe authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.Reviewer disclosuresPeer reviewers on this manuscript have no relevant financial or other relationships to disclose.Figure 1. Molecular mechanism of liver X receptor (LXR) transcriptional activation.Display full sizeFigure 2. The antitumor mechanisms of liver X receptors (LXRs) in immunity.Display full sizeFigure 3. The effect of liver X receptor (LXR) activation on dendritic cells (DCs).Display full sizeFigure 4. Liver X receptor (LXR)-related reverse cholesterol transport in macrophages.Display full sizeAdditional informationFundingThis manuscript was funded by key research and development program of Zhenjiang [SH2023039] and the Students’ platform for innovation and entrepreneurship training programme [202310299015Z]." @default.
- W4387078162 created "2023-09-28" @default.
- W4387078162 creator A5000957687 @default.
- W4387078162 creator A5030799319 @default.
- W4387078162 creator A5036781407 @default.
- W4387078162 creator A5037677450 @default.
- W4387078162 creator A5086595329 @default.
- W4387078162 creator A5089460772 @default.
- W4387078162 date "2023-09-27" @default.
- W4387078162 modified "2023-10-14" @default.
- W4387078162 title "Regulatory mechanism underlying liver X receptor effects on the tumor microenvironment, inflammation and tumorigenesis" @default.
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