Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387078233> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W4387078233 abstract "Enantioconvergent catalysis enables the conversion of racemic molecules into a single enantiomer in perfect yield and is considered an ideal approach for asymmetric synthesis. Despite remarkable advances in this field, enantioconvergent transformations of inert tertiary C−H bonds remain largely unexplored due to the high bond dissociation energy and the surrounding steric repulsion that pose unparalleled constraints on bond cleavage and formation. Here, we report an enantioconvergent Pd‐catalyzed alkylation of racemic tertiary allylic C−H bonds of α‐alkenes, providing a unique approach to access a broad range of enantioenriched γ,δ‐unsaturated carbonyl compounds featuring quaternary carbon stereocenters. Mechanistic studies reveal that a stereoablative event occurs through the rate‐limiting cleavage of tertiary allylic C–H bonds to generate σ‐allyl‐Pd species, and the achieved E/Z‐selectivity of σ‐allyl‐Pd species effectively regulates the diastereoselectivity via a nucleophile coordination‐enabled SN2'‐allylation pathway." @default.
- W4387078233 created "2023-09-28" @default.
- W4387078233 creator A5006545964 @default.
- W4387078233 creator A5009790777 @default.
- W4387078233 creator A5054872651 @default.
- W4387078233 creator A5080902320 @default.
- W4387078233 creator A5082627703 @default.
- W4387078233 date "2023-09-27" @default.
- W4387078233 modified "2023-10-13" @default.
- W4387078233 title "Enantioconvergent Palladium‐Catalyzed Alkylation of Tertiary Allylic C−H Bonds" @default.
- W4387078233 doi "https://doi.org/10.1002/anie.202312547" @default.
- W4387078233 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37752890" @default.
- W4387078233 hasPublicationYear "2023" @default.
- W4387078233 type Work @default.
- W4387078233 citedByCount "0" @default.
- W4387078233 crossrefType "journal-article" @default.
- W4387078233 hasAuthorship W4387078233A5006545964 @default.
- W4387078233 hasAuthorship W4387078233A5009790777 @default.
- W4387078233 hasAuthorship W4387078233A5054872651 @default.
- W4387078233 hasAuthorship W4387078233A5080902320 @default.
- W4387078233 hasAuthorship W4387078233A5082627703 @default.
- W4387078233 hasConcept C120095180 @default.
- W4387078233 hasConcept C134195300 @default.
- W4387078233 hasConcept C146686406 @default.
- W4387078233 hasConcept C155647269 @default.
- W4387078233 hasConcept C161790260 @default.
- W4387078233 hasConcept C164361826 @default.
- W4387078233 hasConcept C178790620 @default.
- W4387078233 hasConcept C178907741 @default.
- W4387078233 hasConcept C185592680 @default.
- W4387078233 hasConcept C201194858 @default.
- W4387078233 hasConcept C21951064 @default.
- W4387078233 hasConcept C27083343 @default.
- W4387078233 hasConcept C2776254738 @default.
- W4387078233 hasConcept C3044715 @default.
- W4387078233 hasConcept C486523 @default.
- W4387078233 hasConcept C502130503 @default.
- W4387078233 hasConcept C71240020 @default.
- W4387078233 hasConceptScore W4387078233C120095180 @default.
- W4387078233 hasConceptScore W4387078233C134195300 @default.
- W4387078233 hasConceptScore W4387078233C146686406 @default.
- W4387078233 hasConceptScore W4387078233C155647269 @default.
- W4387078233 hasConceptScore W4387078233C161790260 @default.
- W4387078233 hasConceptScore W4387078233C164361826 @default.
- W4387078233 hasConceptScore W4387078233C178790620 @default.
- W4387078233 hasConceptScore W4387078233C178907741 @default.
- W4387078233 hasConceptScore W4387078233C185592680 @default.
- W4387078233 hasConceptScore W4387078233C201194858 @default.
- W4387078233 hasConceptScore W4387078233C21951064 @default.
- W4387078233 hasConceptScore W4387078233C27083343 @default.
- W4387078233 hasConceptScore W4387078233C2776254738 @default.
- W4387078233 hasConceptScore W4387078233C3044715 @default.
- W4387078233 hasConceptScore W4387078233C486523 @default.
- W4387078233 hasConceptScore W4387078233C502130503 @default.
- W4387078233 hasConceptScore W4387078233C71240020 @default.
- W4387078233 hasLocation W43870782331 @default.
- W4387078233 hasLocation W43870782332 @default.
- W4387078233 hasOpenAccess W4387078233 @default.
- W4387078233 hasPrimaryLocation W43870782331 @default.
- W4387078233 hasRelatedWork W164524458 @default.
- W4387078233 hasRelatedWork W1916349588 @default.
- W4387078233 hasRelatedWork W1994014024 @default.
- W4387078233 hasRelatedWork W2076353988 @default.
- W4387078233 hasRelatedWork W2102790079 @default.
- W4387078233 hasRelatedWork W2144257013 @default.
- W4387078233 hasRelatedWork W2806984475 @default.
- W4387078233 hasRelatedWork W2902584051 @default.
- W4387078233 hasRelatedWork W3175053346 @default.
- W4387078233 hasRelatedWork W2949940783 @default.
- W4387078233 isParatext "false" @default.
- W4387078233 isRetracted "false" @default.
- W4387078233 workType "article" @default.