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- W4387078284 abstract "Abstract This review compiles the mechanisms of acute liver failure (ALF) as well as the current and potential therapeutic approaches, including aetiology‐specific treatment, and the issues encountered with such approaches. On a cellular level, ALF is characterized by massive hepatocyte death due to different types of cellular demise. Compensatory hyperplasia and functional recovery are possible when the regenerative capacity is sufficient to sustain hepatic function. ALF has a high mortality of about 30% and can lead to death in a very short time despite maximum therapeutic intervention. Besides aetiology‐specific therapy and intensive care, the therapeutic option of emergency liver transplantation has significantly improved the prognosis of patients with ALF. However, due to limiting factors such as organ shortage, many patients die on the waiting list. In addition to graft assessment, machine perfusion may have the potential to recondition marginal organs and thus expand the organ donor pool." @default.
- W4387078284 created "2023-09-28" @default.
- W4387078284 creator A5001703227 @default.
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- W4387078284 creator A5012430341 @default.
- W4387078284 creator A5023914331 @default.
- W4387078284 creator A5031616590 @default.
- W4387078284 date "2023-09-26" @default.
- W4387078284 modified "2023-09-28" @default.
- W4387078284 title "Mechanisms and aetiology‐dependent treatment of acute liver failure" @default.
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