FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387079148> ?p ?o ?g. }

• W4387079148 endingPage "10" @default.
• W4387079148 startingPage "1" @default.
• W4387079148 abstract "In cattle, 17β-estradiol (E2) is essential for triggering luteolysis via the synthesis of prostaglandin F2α (PGF2α). We aimed to evaluate the effects of E2-treatment on day 15 of the estrous cycle on the transcript abundance of genes involved in the PGF2α synthetic cascade. Nelore heifers (N = 50) were subjected to a hormonal protocol for the synchronization of ovulation. Between days 14 and 23 after estrus, the area (cm2) and blood perfusion (%) of the corpus luteum (CL) and progesterone (P4) plasma concentrations were evaluated daily. On day 15, the heifers were assigned to the Control (2 mL of pure sesame oil, N = 21) or Estradiol group (1 mg of E2 diluted in 2 mL of sesame oil, N = 23). After the treatments at 0 h, uterine biopsies were collected at times 1.5 h (C1.5h, N = 8 and E1.5h, N = 10) or 3 h (C3h, N = 8 and E3h, N = 11); and blood samples were obtained from 0, 3, 4, 6 and 7 h for the measurement of 13,14-dihydro-15-keto-PGF2α (PGFM) concentrations by ELISA. Transcript abundance was determined by RT-qPCR and protein abundance of ESRβ and OXTR was determined by Western Blotting. The Estradiol group showed greater (P < 0.05) concentrations of PGFM at 6 and 7 h compared to the Control group. A progressive decrease in plasma P4 concentrations characterized a hastened functional luteolysis, followed by structural luteolysis in the Estradiol group (P < 0.05). Among the treatment groups, no significant difference was detected for the abundance of PRKCα, PRKCβ, AKR1B1, PTGS2 and ESRα transcripts (P > 0.05). Estradiol treatment decreased the abundance of PLA2G4A, AKR1C4, and ESRβ both 1.5h and 3h after treatment (P < 0.05). The relative expression of PGR and OXTR was greater in E3h compared to the C3h (P > 0.05). Protein abundance did not differ between treatment groups at either experimental times (P > 0.05). Overall, E2 promoted an increase in PGFM concentrations and the hastening of functional and structural luteolysis in Nelore heifers through the upregulation of PGR and OXTR, demonstrating for the first time that the expression of these receptors within 3 h after E2 stimulus was associated with triggering luteolysis in cattle." @default.
• W4387079148 created "2023-09-28" @default.
• W4387079148 creator A5000327838 @default.
• W4387079148 creator A5005714066 @default.
• W4387079148 creator A5009581886 @default.
• W4387079148 creator A5025384160 @default.
• W4387079148 creator A5027387872 @default.
• W4387079148 creator A5059644451 @default.
• W4387079148 creator A5062630916 @default.
• W4387079148 creator A5063647391 @default.
• W4387079148 creator A5088000445 @default.
• W4387079148 creator A5091234431 @default.
• W4387079148 creator A5091253294 @default.
• W4387079148 date "2024-01-01" @default.
• W4387079148 modified "2023-10-17" @default.
• W4387079148 title "Effects of 17β-estradiol on the uterine luteolytic cascade in bovine females at the end of diestrus" @default.
• W4387079148 cites W1659749843 @default.
• W4387079148 cites W1733167316 @default.
• W4387079148 cites W1967270893 @default.
• W4387079148 cites W1970416630 @default.
• W4387079148 cites W1973374178 @default.
• W4387079148 cites W1974712212 @default.
• W4387079148 cites W1977725483 @default.
• W4387079148 cites W1984564597 @default.
• W4387079148 cites W1986129664 @default.
• W4387079148 cites W1986884292 @default.
• W4387079148 cites W1988685569 @default.
• W4387079148 cites W2001413289 @default.
• W4387079148 cites W2002071939 @default.
• W4387079148 cites W2002769936 @default.
• W4387079148 cites W2011899256 @default.
• W4387079148 cites W2015769477 @default.
• W4387079148 cites W2016260052 @default.
• W4387079148 cites W2018925187 @default.
• W4387079148 cites W2031432118 @default.
• W4387079148 cites W2035034711 @default.
• W4387079148 cites W2035158789 @default.
• W4387079148 cites W2038356261 @default.
• W4387079148 cites W2041276572 @default.
• W4387079148 cites W2041786228 @default.
• W4387079148 cites W2041946544 @default.
• W4387079148 cites W2043228339 @default.
• W4387079148 cites W2044830018 @default.
• W4387079148 cites W2046425272 @default.
• W4387079148 cites W2060092135 @default.
• W4387079148 cites W2074506682 @default.
• W4387079148 cites W2078067079 @default.
• W4387079148 cites W2082559087 @default.
• W4387079148 cites W2086523682 @default.
• W4387079148 cites W2086910152 @default.
• W4387079148 cites W2098320457 @default.
• W4387079148 cites W2101104217 @default.
• W4387079148 cites W2108244474 @default.
• W4387079148 cites W2113650514 @default.
• W4387079148 cites W2116752880 @default.
• W4387079148 cites W2116883094 @default.
• W4387079148 cites W2136940049 @default.
• W4387079148 cites W2138071010 @default.
• W4387079148 cites W2149489546 @default.
• W4387079148 cites W2153621482 @default.
• W4387079148 cites W2161461045 @default.
• W4387079148 cites W2163760661 @default.
• W4387079148 cites W2166567860 @default.
• W4387079148 cites W2170348947 @default.
• W4387079148 cites W2209762229 @default.
• W4387079148 cites W2338862446 @default.
• W4387079148 cites W2971445887 @default.
• W4387079148 cites W3121985268 @default.
• W4387079148 cites W3136472648 @default.
• W4387079148 cites W3190726109 @default.
• W4387079148 cites W4289525114 @default.
• W4387079148 doi "https://doi.org/10.1016/j.theriogenology.2023.09.019" @default.
• W4387079148 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37783065" @default.
• W4387079148 hasPublicationYear "2024" @default.
• W4387079148 type Work @default.
• W4387079148 citedByCount "0" @default.
• W4387079148 crossrefType "journal-article" @default.
• W4387079148 hasAuthorship W4387079148A5000327838 @default.
• W4387079148 hasAuthorship W4387079148A5005714066 @default.
• W4387079148 hasAuthorship W4387079148A5009581886 @default.
• W4387079148 hasAuthorship W4387079148A5025384160 @default.
• W4387079148 hasAuthorship W4387079148A5027387872 @default.
• W4387079148 hasAuthorship W4387079148A5059644451 @default.
• W4387079148 hasAuthorship W4387079148A5062630916 @default.
• W4387079148 hasAuthorship W4387079148A5063647391 @default.
• W4387079148 hasAuthorship W4387079148A5088000445 @default.
• W4387079148 hasAuthorship W4387079148A5091234431 @default.
• W4387079148 hasAuthorship W4387079148A5091253294 @default.
• W4387079148 hasConcept C126322002 @default.
• W4387079148 hasConcept C134018914 @default.
• W4387079148 hasConcept C140793950 @default.
• W4387079148 hasConcept C16685009 @default.
• W4387079148 hasConcept C185592680 @default.
• W4387079148 hasConcept C1998276 @default.
• W4387079148 hasConcept C2776608385 @default.
• W4387079148 hasConcept C2777330693 @default.
• W4387079148 hasConcept C2777702977 @default.
• W4387079148 hasConcept C2780664492 @default.

• next