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• W4387079169 endingPage "167435" @default.
• W4387079169 startingPage "167435" @default.
• W4387079169 abstract "Metals, including lead (Pb), manganese (Mn), chromium (Cr) and copper (Cu), have been associated with neurodevelopment; iron (Fe) plays a role in the metabolism and neurotoxicity of metals, suggesting Fe may mediate metal-neurodevelopment associations. However, no study to date has examined Fe as a mediator of the association between metal mixtures and neurodevelopment. We assessed Fe status as a mediator of a mixture of Pb, Mn, Cr and Cu in relation to verbal learning and memory in a cohort of Italian adolescents. We used cross-sectional data from 383 adolescents (10–14 years) in the Public Health Impact of Metals Exposure Study. Metals were quantified in blood (Pb) or hair (Mn, Cr, Cu) using ICP-MS, and three metrics of Fe status (blood hemoglobin, serum ferritin and transferrin) were quantified using luminescence assays or immunoassays. Verbal learning and memory were assessed using the California Verbal Learning Test for Children (CVLT-C). We used Bayesian Kernel Machine Regression Causal Mediation Analysis to estimate four mediation effects: the natural direct effect (NDE), natural indirect effect (NIE), controlled direct effect (CDE) and total effect (TE). Beta (β) coefficients and 95 % credible intervals (CIs) were estimated for all effects. The metal mixture was jointly associated with a greater number of words recalled on the CVLT-C, but these associations were not mediated by Fe status. For example, when ferritin was considered as the mediator, the NIE for long delay free recall was null (β = 0.00; 95 % CI = −0.22, 0.23). Conversely, the NDE (β = 0.23; 95 % CI = 0.01, 0.44) indicated a beneficial association of the mixture with recall that operated independently of Fe status. An industry-relevant metal mixture was associated with learning and memory, but there was no evidence of mediation by Fe status. Further studies in populations with Fe deficiency and greater variation in metal exposure are warranted." @default.
• W4387079169 created "2023-09-28" @default.
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• W4387079169 date "2024-01-01" @default.
• W4387079169 modified "2023-10-07" @default.
• W4387079169 title "Assessing the mediating role of iron status on associations between an industry-relevant metal mixture and verbal learning and memory in Italian adolescents" @default.
• W4387079169 cites W1979247330 @default.
• W4387079169 cites W1985092163 @default.
• W4387079169 cites W1986183560 @default.
• W4387079169 cites W1995940893 @default.
• W4387079169 cites W1999029956 @default.
• W4387079169 cites W2001575125 @default.
• W4387079169 cites W2001624515 @default.
• W4387079169 cites W2002249066 @default.
• W4387079169 cites W2003071749 @default.
• W4387079169 cites W2005441291 @default.
• W4387079169 cites W2005529814 @default.
• W4387079169 cites W2009033194 @default.
• W4387079169 cites W2010728755 @default.
• W4387079169 cites W2011476170 @default.
• W4387079169 cites W2016623748 @default.
• W4387079169 cites W2028176757 @default.
• W4387079169 cites W2028662420 @default.
• W4387079169 cites W2030562185 @default.
• W4387079169 cites W2036239299 @default.
• W4387079169 cites W2038058487 @default.
• W4387079169 cites W2043368865 @default.
• W4387079169 cites W2046200968 @default.
• W4387079169 cites W2047814923 @default.
• W4387079169 cites W2049250976 @default.
• W4387079169 cites W2050237932 @default.
• W4387079169 cites W2053141566 @default.
• W4387079169 cites W2053191107 @default.
• W4387079169 cites W2056694377 @default.
• W4387079169 cites W2062800202 @default.
• W4387079169 cites W2064567214 @default.
• W4387079169 cites W2064612203 @default.
• W4387079169 cites W2066226784 @default.
• W4387079169 cites W2071053091 @default.
• W4387079169 cites W2073263177 @default.
• W4387079169 cites W2077996034 @default.
• W4387079169 cites W2084037331 @default.
• W4387079169 cites W2088097018 @default.
• W4387079169 cites W2088655915 @default.
• W4387079169 cites W2093685823 @default.
• W4387079169 cites W2099704407 @default.
• W4387079169 cites W2100850796 @default.
• W4387079169 cites W2104360637 @default.
• W4387079169 cites W2112516091 @default.
• W4387079169 cites W2113885080 @default.
• W4387079169 cites W2116199693 @default.
• W4387079169 cites W2125771903 @default.
• W4387079169 cites W2128610713 @default.
• W4387079169 cites W2128617741 @default.
• W4387079169 cites W2131208076 @default.
• W4387079169 cites W2131626819 @default.
• W4387079169 cites W2134462026 @default.
• W4387079169 cites W2134694407 @default.
• W4387079169 cites W2136588713 @default.
• W4387079169 cites W2139916990 @default.
• W4387079169 cites W2141594472 @default.
• W4387079169 cites W2144579323 @default.
• W4387079169 cites W2156207817 @default.
• W4387079169 cites W2163472591 @default.
• W4387079169 cites W2171588737 @default.
• W4387079169 cites W2182962053 @default.
• W4387079169 cites W2340320436 @default.
• W4387079169 cites W2517341032 @default.
• W4387079169 cites W2588520772 @default.
• W4387079169 cites W2608466962 @default.
• W4387079169 cites W2730524918 @default.
• W4387079169 cites W2755905423 @default.
• W4387079169 cites W2757097042 @default.
• W4387079169 cites W2760375546 @default.
• W4387079169 cites W2783143899 @default.
• W4387079169 cites W2789820493 @default.
• W4387079169 cites W2790770877 @default.
• W4387079169 cites W2801556408 @default.
• W4387079169 cites W2886775863 @default.
• W4387079169 cites W2888209655 @default.
• W4387079169 cites W2890804838 @default.
• W4387079169 cites W2895803213 @default.
• W4387079169 cites W2912157567 @default.
• W4387079169 cites W2942067946 @default.
• W4387079169 cites W2947232877 @default.
• W4387079169 cites W2954511778 @default.
• W4387079169 cites W2967124299 @default.

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