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- W4387079218 endingPage "122122" @default.
- W4387079218 startingPage "122122" @default.
- W4387079218 abstract "Abnormal cardiac metabolism or cardiac metabolic remodeling is reported before the onset of heart failure with reduced ejection fraction (HFrEF) and is known to trigger and maintain the mechanical dysfunction and electrical, and structural abnormalities of the ventricle. A dysregulated cardiac autonomic tone characterized by sympathetic overdrive with blunted parasympathetic activation is another pathophysiological hallmark of HF. Emerging evidence suggests a link between autonomic nervous system activity and cardiac metabolism. Chronic β-adrenergic activation promotes maladaptive metabolic remodeling whereas cholinergic activation attenuates the metabolic aberrations through favorable modulation of key metabolic regulatory molecules. Restoration of sympathovagal balance by neuromodulation strategies is emerging as a novel nonpharmacological treatment strategy in HF. The current review attempts to evaluate the 'neuro-metabolic axis' in HFrEF and whether neuromodulation can mitigate the adverse metabolic remodeling in HFrEF." @default.
- W4387079218 created "2023-09-28" @default.
- W4387079218 creator A5004208322 @default.
- W4387079218 creator A5022649569 @default.
- W4387079218 creator A5076999391 @default.
- W4387079218 creator A5080736752 @default.
- W4387079218 date "2023-11-01" @default.
- W4387079218 modified "2023-10-15" @default.
- W4387079218 title "The neurometabolic axis: A novel therapeutic target in heart failure" @default.
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- W4387079218 doi "https://doi.org/10.1016/j.lfs.2023.122122" @default.