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• W4387079225 endingPage "103519" @default.
• W4387079225 startingPage "103519" @default.
• W4387079225 abstract "The loss of dopamine in the striatum underlies motor symptoms of Parkinson's disease (PD). Rapid eye movement sleep behaviour disorder (RBD) is considered prodromal PD and has shown similar neural changes in the striatum. Alterations in brain iron suggest neurodegeneration; however, the literature on striatal iron has been inconsistent in PD and scant in RBD. Toward clarifying pathophysiological changes in PD and RBD, and uncovering possible biomarkers, we imaged 26 early-stage PD patients, 16 RBD patients, and 39 age-matched healthy controls with 3 T MRI. We compared mean susceptibility using quantitative susceptibility mapping (QSM) in the standard striatum (caudate, putamen, and nucleus accumbens) and tractography-parcellated striatum. Diffusion MRI permitted parcellation of the striatum into seven subregions based on the cortical areas of maximal connectivity from the Tziortzi atlas. No significant differences in mean susceptibility were found in the standard striatum anatomy. For the parcellated striatum, the caudal motor subregion, the most affected region in PD, showed lower iron levels compared to healthy controls. Receiver operating characteristic curves using mean susceptibility in the caudal motor striatum showed a good diagnostic accuracy of 0.80 when classifying early-stage PD from healthy controls. This study highlights that tractography-based parcellation of the striatum could enhance sensitivity to changes in iron levels, which have not been consistent in the PD literature. The decreased caudal motor striatum iron was sufficiently sensitive to PD, but not RBD. QSM in the striatum could contribute to development of a multivariate or multimodal biomarker of early-stage PD, but further work in larger datasets is needed to confirm its utility in prodromal groups." @default.
• W4387079225 created "2023-09-28" @default.
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• W4387079225 date "2023-01-01" @default.
• W4387079225 modified "2023-10-18" @default.
• W4387079225 title "Subregional analysis of striatum iron in Parkinson’s disease and rapid eye movement sleep behaviour disorder" @default.
• W4387079225 cites W1498733903 @default.
• W4387079225 cites W1593182658 @default.
• W4387079225 cites W1593930369 @default.
• W4387079225 cites W1967659552 @default.
• W4387079225 cites W1972319230 @default.
• W4387079225 cites W1981835221 @default.
• W4387079225 cites W1981903187 @default.
• W4387079225 cites W1984453610 @default.
• W4387079225 cites W1985613988 @default.
• W4387079225 cites W1997122959 @default.
• W4387079225 cites W1997183854 @default.
• W4387079225 cites W2002867180 @default.
• W4387079225 cites W2008445652 @default.
• W4387079225 cites W2008560062 @default.
• W4387079225 cites W2019738036 @default.
• W4387079225 cites W2023130608 @default.
• W4387079225 cites W2026752633 @default.
• W4387079225 cites W2035198783 @default.
• W4387079225 cites W2050113652 @default.
• W4387079225 cites W2091910928 @default.
• W4387079225 cites W2101135654 @default.
• W4387079225 cites W2107956652 @default.
• W4387079225 cites W2123913108 @default.
• W4387079225 cites W2127309075 @default.
• W4387079225 cites W2128017834 @default.
• W4387079225 cites W2133955737 @default.
• W4387079225 cites W2149092213 @default.
• W4387079225 cites W2150298956 @default.
• W4387079225 cites W2150312009 @default.
• W4387079225 cites W2152552783 @default.
• W4387079225 cites W2154600934 @default.
• W4387079225 cites W2164561646 @default.
• W4387079225 cites W2165758561 @default.
• W4387079225 cites W2166211493 @default.
• W4387079225 cites W2168205746 @default.
• W4387079225 cites W2171800484 @default.
• W4387079225 cites W2292251439 @default.
• W4387079225 cites W2294172555 @default.
• W4387079225 cites W2327686392 @default.
• W4387079225 cites W2336893408 @default.
• W4387079225 cites W2470259419 @default.
• W4387079225 cites W2474259138 @default.
• W4387079225 cites W2508982726 @default.
• W4387079225 cites W2517121990 @default.
• W4387079225 cites W2539957110 @default.
• W4387079225 cites W2559405322 @default.
• W4387079225 cites W2606337386 @default.
• W4387079225 cites W2610862164 @default.
• W4387079225 cites W2737166034 @default.
• W4387079225 cites W2741826558 @default.
• W4387079225 cites W2743165471 @default.
• W4387079225 cites W2758113150 @default.
• W4387079225 cites W2767027378 @default.
• W4387079225 cites W2768364432 @default.
• W4387079225 cites W2802434510 @default.
• W4387079225 cites W2808495410 @default.
• W4387079225 cites W2897320412 @default.
• W4387079225 cites W2898132477 @default.
• W4387079225 cites W2901069064 @default.
• W4387079225 cites W2904404980 @default.
• W4387079225 cites W2917107887 @default.
• W4387079225 cites W2929714440 @default.
• W4387079225 cites W2945475836 @default.
• W4387079225 cites W2946627637 @default.
• W4387079225 cites W2951103577 @default.
• W4387079225 cites W2953134824 @default.
• W4387079225 cites W2962681100 @default.
• W4387079225 cites W2977883299 @default.
• W4387079225 cites W2995376722 @default.
• W4387079225 cites W3021955698 @default.
• W4387079225 cites W3031196681 @default.
• W4387079225 cites W3131532480 @default.
• W4387079225 cites W3163106865 @default.
• W4387079225 cites W3163737948 @default.
• W4387079225 cites W3186052749 @default.
• W4387079225 cites W3197579772 @default.
• W4387079225 cites W3203040313 @default.
• W4387079225 cites W3204330673 @default.
• W4387079225 cites W4235806146 @default.
• W4387079225 cites W4285097303 @default.
• W4387079225 cites W4318767763 @default.
• W4387079225 cites W4320489431 @default.

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