FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387079633> ?p ?o ?g. }

• W4387079633 endingPage "105625" @default.
• W4387079633 startingPage "105625" @default.
• W4387079633 abstract "Vascular dementia (VD) is the second most common cause of dementia after Alzheimer's disease. Neuroinflammation contributes to pathogenesis of VD. Neurotropin (NTP) is an analgesic that has been shown to suppress inflammation and neural repair. But its effects on VD are still unclear. Therefore, this study aimed to investigate the therapeutic effects and potential mechanisms of NTP in the VD model mice established by bilateral common carotid artery stenosis method. In VD mice, we found that NTP treatment increased cerebral blood flow by Laser speckle imaging, reduced neuron loss by Nissl, HE and immunochemistry staining, attenuated white matter damage by magnetic resonance imaging and ultrastructural damage by transmission electron microscope, improved cognitive functions by new object recognition test and three-chamber test, Y maze test and Morris water maze test, inhibited significantly glial activation by immunofluorescence methods, reduced the expression of TLR4, down-regulated expression of MyD88 and phosphorylation of NF-κB P65, decreased the levels of pro-inflammatory cytokines IL-1β, IL-6 and TNFα. Further, we showed that administration of a TLR4 inhibitor TAK242 had a similar effect to NTP, while the TLR4 agonist CRX-527 attenuated the effect of NTP in the VD mice. Collectively, our study suggested that NTP alleviates cognitive impairment by inhibiting TLR4/MyD88/NF-κB inflammation signaling pathway in the VD mice. Thus, NTP may be a promising therapeutic approach and a potential TLR4 inhibitor for VD." @default.
• W4387079633 created "2023-09-28" @default.
• W4387079633 creator A5020676504 @default.
• W4387079633 creator A5032187447 @default.
• W4387079633 creator A5061715948 @default.
• W4387079633 creator A5069310936 @default.
• W4387079633 creator A5069507022 @default.
• W4387079633 creator A5075200419 @default.
• W4387079633 creator A5075238491 @default.
• W4387079633 creator A5081531782 @default.
• W4387079633 date "2023-12-01" @default.
• W4387079633 modified "2023-10-18" @default.
• W4387079633 title "Neurotropin alleviates cognitive impairment by inhibiting TLR4/MyD88/NF-κB inflammation signaling pathway in mice with vascular dementia" @default.
• W4387079633 cites W1551533003 @default.
• W4387079633 cites W171062923 @default.
• W4387079633 cites W1981046449 @default.
• W4387079633 cites W1982771150 @default.
• W4387079633 cites W1991495749 @default.
• W4387079633 cites W2005695657 @default.
• W4387079633 cites W2007227555 @default.
• W4387079633 cites W2016561117 @default.
• W4387079633 cites W2033023829 @default.
• W4387079633 cites W203307167 @default.
• W4387079633 cites W2037426713 @default.
• W4387079633 cites W2042340624 @default.
• W4387079633 cites W2058971571 @default.
• W4387079633 cites W2070325134 @default.
• W4387079633 cites W2073578515 @default.
• W4387079633 cites W2121416631 @default.
• W4387079633 cites W2122735610 @default.
• W4387079633 cites W2124779892 @default.
• W4387079633 cites W2136002830 @default.
• W4387079633 cites W2137324084 @default.
• W4387079633 cites W2139224335 @default.
• W4387079633 cites W2145252529 @default.
• W4387079633 cites W2153397468 @default.
• W4387079633 cites W2156523000 @default.
• W4387079633 cites W2158591358 @default.
• W4387079633 cites W2165413779 @default.
• W4387079633 cites W2195487135 @default.
• W4387079633 cites W2398672153 @default.
• W4387079633 cites W2591664460 @default.
• W4387079633 cites W2604235446 @default.
• W4387079633 cites W2774879582 @default.
• W4387079633 cites W2780720325 @default.
• W4387079633 cites W2793176866 @default.
• W4387079633 cites W2793666671 @default.
• W4387079633 cites W2799391697 @default.
• W4387079633 cites W2896540078 @default.
• W4387079633 cites W2902160817 @default.
• W4387079633 cites W2907888739 @default.
• W4387079633 cites W2946315700 @default.
• W4387079633 cites W2978931957 @default.
• W4387079633 cites W2993675266 @default.
• W4387079633 cites W3006628140 @default.
• W4387079633 cites W3013502527 @default.
• W4387079633 cites W3042528727 @default.
• W4387079633 cites W3083573863 @default.
• W4387079633 cites W3121912114 @default.
• W4387079633 cites W3167967119 @default.
• W4387079633 cites W3172032590 @default.
• W4387079633 cites W3189733450 @default.
• W4387079633 cites W3205342976 @default.
• W4387079633 cites W4205480060 @default.
• W4387079633 cites W4205758540 @default.
• W4387079633 cites W4240214838 @default.
• W4387079633 cites W4379014645 @default.
• W4387079633 doi "https://doi.org/10.1016/j.neuint.2023.105625" @default.
• W4387079633 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37774797" @default.
• W4387079633 hasPublicationYear "2023" @default.
• W4387079633 type Work @default.
• W4387079633 citedByCount "0" @default.
• W4387079633 crossrefType "journal-article" @default.
• W4387079633 hasAuthorship W4387079633A5020676504 @default.
• W4387079633 hasAuthorship W4387079633A5032187447 @default.
• W4387079633 hasAuthorship W4387079633A5061715948 @default.
• W4387079633 hasAuthorship W4387079633A5069310936 @default.
• W4387079633 hasAuthorship W4387079633A5069507022 @default.
• W4387079633 hasAuthorship W4387079633A5075200419 @default.
• W4387079633 hasAuthorship W4387079633A5075238491 @default.
• W4387079633 hasAuthorship W4387079633A5081531782 @default.
• W4387079633 hasBestOaLocation W43870796331 @default.
• W4387079633 hasConcept C126322002 @default.
• W4387079633 hasConcept C134018914 @default.
• W4387079633 hasConcept C142724271 @default.
• W4387079633 hasConcept C164027704 @default.
• W4387079633 hasConcept C169760540 @default.
• W4387079633 hasConcept C2776070231 @default.
• W4387079633 hasConcept C2776914184 @default.
• W4387079633 hasConcept C2777952318 @default.
• W4387079633 hasConcept C2779134260 @default.
• W4387079633 hasConcept C2779483572 @default.
• W4387079633 hasConcept C2781161787 @default.
• W4387079633 hasConcept C44752575 @default.
• W4387079633 hasConcept C71924100 @default.
• W4387079633 hasConcept C86803240 @default.
• W4387079633 hasConcept C87753298 @default.
• W4387079633 hasConcept C98274493 @default.

• next