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• W4387081323 abstract "Abstract To explore the mechanisms behind tumor electric field treatment (TEFT) in reversing temozolomide (TMZ) resistance in glioblastoma (GBM). Transcriptome data of TMZ- resistant GBM cells treated with TEFT were obtained using a novel electric field cell culture device (CL-301A). Key biological processes and genes were identified through differential gene analysis and enrichment analysis. The association between key genes and patient prognosis was examined using a GBM open-source database. The results were validated in two GBM-resistant cell lines(U251R,T98GR)and primary cell lines (GPDC1,GPDC8). The results suggest that TEFT increased the sensitivity of U251R and T98GR to TMZ. Bioinformatics analysis showed the importance of the extracellular matrix structure and identified BCL3 as a key gene. Survival analysis indicated that GBM patients with high BCL3 expression had a poor prognosis. BCL3 was upregulated in U251R and T98GR, increased resistance to TMZ, while BCL3 knockdown resulted in increased sensitivity to TMZ. Western blot assays showed that downregulation of BCL3 decreased AKT phosphorylation and correlated with reduced resistance to TMZ. It was finally concluded that TEFT reversed the drug resistance of GBM to TMZ by reducing AKT phosphorylation and BCL3 expression, enhancing the proapoptotic effect of TMZ on GBM cells. Keywords: tumor electric field therapy; BCL3; drug resistance; glioblastoma; temozolomide." @default.
• W4387081323 created "2023-09-28" @default.
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• W4387081323 date "2023-09-27" @default.
• W4387081323 modified "2023-10-06" @default.
• W4387081323 title "Mechanisms of reversal of temozolomide resistance in glioblastoma through downregulation of BCL3 by the Tumor Electric Field Therapy" @default.
• W4387081323 doi "https://doi.org/10.21203/rs.3.rs-3301483/v1" @default.
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