Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387083843> ?p ?o ?g. }
- W4387083843 endingPage "113176" @default.
- W4387083843 startingPage "113176" @default.
- W4387083843 abstract "MCL-1 is a high-priority target due to its dominant role in the pathogenesis and chemoresistance of cancer, yet clinical trials of MCL-1 inhibitors are revealing toxic side effects. MCL-1 biology is complex, extending beyond apoptotic regulation and confounded by its multiple isoforms, its domains of unresolved structure and function, and challenges in distinguishing noncanonical activities from the apoptotic response. We find that, in the presence or absence of an intact mitochondrial apoptotic pathway, genetic deletion or pharmacologic targeting of MCL-1 induces DNA damage and retards cell proliferation. Indeed, the cancer cell susceptibility profile of MCL-1 inhibitors better matches that of anti-proliferative than pro-apoptotic drugs, expanding their potential therapeutic applications, including synergistic combinations, but heightening therapeutic window concerns. Proteomic profiling provides a resource for mechanistic dissection and reveals the minichromosome maintenance DNA helicase as an interacting nuclear protein complex that links MCL-1 to the regulation of DNA integrity and cell-cycle progression." @default.
- W4387083843 created "2023-09-28" @default.
- W4387083843 creator A5004787236 @default.
- W4387083843 creator A5013448420 @default.
- W4387083843 creator A5020222350 @default.
- W4387083843 creator A5026734370 @default.
- W4387083843 creator A5035008583 @default.
- W4387083843 creator A5041594267 @default.
- W4387083843 creator A5048704959 @default.
- W4387083843 creator A5052507376 @default.
- W4387083843 creator A5058382295 @default.
- W4387083843 creator A5071163756 @default.
- W4387083843 creator A5072929658 @default.
- W4387083843 creator A5079793809 @default.
- W4387083843 date "2023-10-01" @default.
- W4387083843 modified "2023-10-14" @default.
- W4387083843 title "Targeting MCL-1 triggers DNA damage and an anti-proliferative response independent from apoptosis induction" @default.
- W4387083843 cites W1418224 @default.
- W4387083843 cites W1976720365 @default.
- W4387083843 cites W1984324503 @default.
- W4387083843 cites W1984754431 @default.
- W4387083843 cites W1986722992 @default.
- W4387083843 cites W1988146323 @default.
- W4387083843 cites W1990983360 @default.
- W4387083843 cites W1992089991 @default.
- W4387083843 cites W2008845432 @default.
- W4387083843 cites W2009790690 @default.
- W4387083843 cites W2012626734 @default.
- W4387083843 cites W2017333581 @default.
- W4387083843 cites W2026873116 @default.
- W4387083843 cites W2031793643 @default.
- W4387083843 cites W2041399392 @default.
- W4387083843 cites W2043398720 @default.
- W4387083843 cites W2044388181 @default.
- W4387083843 cites W2053105723 @default.
- W4387083843 cites W2059871989 @default.
- W4387083843 cites W2059958613 @default.
- W4387083843 cites W2062133747 @default.
- W4387083843 cites W2064937772 @default.
- W4387083843 cites W2070050178 @default.
- W4387083843 cites W2073031672 @default.
- W4387083843 cites W2073825741 @default.
- W4387083843 cites W2085419794 @default.
- W4387083843 cites W2089273345 @default.
- W4387083843 cites W2096057003 @default.
- W4387083843 cites W2098276373 @default.
- W4387083843 cites W2098629192 @default.
- W4387083843 cites W2106799894 @default.
- W4387083843 cites W2117692326 @default.
- W4387083843 cites W2120921507 @default.
- W4387083843 cites W2123347941 @default.
- W4387083843 cites W2132740145 @default.
- W4387083843 cites W2136910701 @default.
- W4387083843 cites W2139123529 @default.
- W4387083843 cites W2148043260 @default.
- W4387083843 cites W2152247516 @default.
- W4387083843 cites W2152883907 @default.
- W4387083843 cites W2153056550 @default.
- W4387083843 cites W2154141161 @default.
- W4387083843 cites W2159482845 @default.
- W4387083843 cites W2163717251 @default.
- W4387083843 cites W2168270559 @default.
- W4387083843 cites W2294987656 @default.
- W4387083843 cites W2294990791 @default.
- W4387083843 cites W2489003193 @default.
- W4387083843 cites W2491691281 @default.
- W4387083843 cites W2534349779 @default.
- W4387083843 cites W2616561032 @default.
- W4387083843 cites W2761167910 @default.
- W4387083843 cites W2775609536 @default.
- W4387083843 cites W2794049848 @default.
- W4387083843 cites W2800169557 @default.
- W4387083843 cites W2926677816 @default.
- W4387083843 cites W2953067954 @default.
- W4387083843 cites W3003119869 @default.
- W4387083843 cites W3009182715 @default.
- W4387083843 cites W3154819335 @default.
- W4387083843 cites W3157357317 @default.
- W4387083843 cites W3174563165 @default.
- W4387083843 cites W3197313036 @default.
- W4387083843 cites W3208691473 @default.
- W4387083843 cites W4220888985 @default.
- W4387083843 cites W4256409604 @default.
- W4387083843 cites W4301394769 @default.
- W4387083843 cites W974578078 @default.
- W4387083843 doi "https://doi.org/10.1016/j.celrep.2023.113176" @default.
- W4387083843 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37773750" @default.
- W4387083843 hasPublicationYear "2023" @default.
- W4387083843 type Work @default.
- W4387083843 citedByCount "0" @default.
- W4387083843 crossrefType "journal-article" @default.
- W4387083843 hasAuthorship W4387083843A5004787236 @default.
- W4387083843 hasAuthorship W4387083843A5013448420 @default.
- W4387083843 hasAuthorship W4387083843A5020222350 @default.
- W4387083843 hasAuthorship W4387083843A5026734370 @default.
- W4387083843 hasAuthorship W4387083843A5035008583 @default.
- W4387083843 hasAuthorship W4387083843A5041594267 @default.
- W4387083843 hasAuthorship W4387083843A5048704959 @default.