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• W4387091803 abstract "Natriuretic peptides (NPs) are hormones with a range of key functions vital for cardiometabolic health. However, the reference ranges of NPs and the prevalence of NP deficiency in the healthy United States population remains poorly defined.This study aims to establish the reference range for N-terminal pro-B-type natriuretic peptide (NT-proBNP) values and to assess the prevalence of NP deficiency in a nationally representative healthy United States population.Healthy participants with NT-proBNP measurements from the 1999-2004 National Health and Nutrition Examination Survey were included. Weighted multivariable-adjusted linear regression models were used to assess the adjusted percentage difference of NT-proBNP concentrations by sex and race and ethnicity. NP deficiency was defined as concentrations <2.5th percentile in the study cohort.Among 18,145 individuals (median age: 33.9 years [IQR: 17.1, 49.0 years], 49.8% males, and 68.5% non-Hispanic White individuals), females had similar NT-proBNP concentrations in the 1-10 years group (4.2% [95% CI: -3.3% to 12.2%]), and highest differences in the 20-30 years group (150.5% [95% CI: 123.5%-180.8%]) compared with males in their respective age groups. Compared with non-Hispanic White individuals, non-Hispanic Black individuals had lower NT-proBNP concentrations in the 1- to 10-years group (19.6% [95% CI: 10.7%-27.6%]), and these differences were most pronounced in the 30-40 years group (40.2% [95% CI: 33.7%-46.0%]). An estimated 9.1 million United States individuals had NP deficiency. NP deficiency was associated with a higher risk of cardiometabolic diseases such as hypertension, dyslipidemia, obesity, and insulin resistance.This study establishes the normative NP concentrations across the lifespan of a healthy United States population." @default.
• W4387091803 created "2023-09-28" @default.
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• W4387091803 date "2023-09-01" @default.
• W4387091803 modified "2023-10-14" @default.
• W4387091803 title "Natriuretic Peptide Normative Levels and Deficiency" @default.
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• W4387091803 doi "https://doi.org/10.1016/j.jchf.2023.07.018" @default.
• W4387091803 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37768244" @default.
• W4387091803 hasPublicationYear "2023" @default.
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