Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387092024> ?p ?o ?g. }
- W4387092024 abstract "Incidence of anal carcinoma (AC) in people living with HIV (PLWH) is increased compared to the general population. Adverse effects of chemoradiotherapy (CRT) on the immune system are associtated with a significant detrimental prognosis on overall survival in patients receiving CRT for solid tumors. The aim of this study was to evaluate immunological factors, in particular the differences in recovery of CD4+ and CD8+ cell counts before and after chemoradiotherapy (CRT) for AC in PLWH.Retrospective single-center chart review extraction, in order to analyze immunological data collected from PLWH with AC; descriptive statistics were used.Thirty-six PLWH with histologically proven AC were inlcuded in the analysis. Absolute CD4 cell count 60 months after CRT was 67.2% of the value at the beginning of CRT, whereas the CD8 cell count reached 82.3%. These differences were statistically significant (p = 0.048), whereas CD4/CD8-ratio remained stable.The findings of the presented study regarding CD4+ and CD8+ cell recovery after CRT are congruent with results from prior studies in Non-HIV infected patients. Although not reaching the level of prior CRT T cell numbers, the ability to generate CD8+ cells seems to be better recovered, while CD4+ regeneration is more impaired. These observations are best explained by faster recovery of CD8+ cells via thymic-independent pathways, which are not available for regeneration of CD4+ cells. Further studies with larger numbers of patients are required to analyse the specific CD4+ and CD8+ cell subsets." @default.
- W4387092024 created "2023-09-28" @default.
- W4387092024 creator A5004966574 @default.
- W4387092024 creator A5019258496 @default.
- W4387092024 creator A5020511633 @default.
- W4387092024 creator A5028185132 @default.
- W4387092024 creator A5028206592 @default.
- W4387092024 creator A5030943230 @default.
- W4387092024 creator A5037785954 @default.
- W4387092024 creator A5047626680 @default.
- W4387092024 creator A5067383538 @default.
- W4387092024 creator A5070006495 @default.
- W4387092024 creator A5084376310 @default.
- W4387092024 creator A5092952439 @default.
- W4387092024 date "2023-09-27" @default.
- W4387092024 modified "2023-09-29" @default.
- W4387092024 title "Differences in the course of CD4 and CD8 cells after chemoradiotherapy in PLWH with anal cancer" @default.
- W4387092024 cites W1481612531 @default.
- W4387092024 cites W1998561285 @default.
- W4387092024 cites W2011070132 @default.
- W4387092024 cites W2017151415 @default.
- W4387092024 cites W2024643457 @default.
- W4387092024 cites W2049998759 @default.
- W4387092024 cites W2102752413 @default.
- W4387092024 cites W2108238886 @default.
- W4387092024 cites W2108714828 @default.
- W4387092024 cites W2144467686 @default.
- W4387092024 cites W2156912242 @default.
- W4387092024 cites W2180656014 @default.
- W4387092024 cites W2291521219 @default.
- W4387092024 cites W2413104908 @default.
- W4387092024 cites W2512407700 @default.
- W4387092024 cites W2558848378 @default.
- W4387092024 cites W2895290062 @default.
- W4387092024 cites W3096793790 @default.
- W4387092024 cites W3156593532 @default.
- W4387092024 cites W84036071 @default.
- W4387092024 doi "https://doi.org/10.1089/aid.2023.0003" @default.
- W4387092024 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37756364" @default.
- W4387092024 hasPublicationYear "2023" @default.
- W4387092024 type Work @default.
- W4387092024 citedByCount "0" @default.
- W4387092024 crossrefType "journal-article" @default.
- W4387092024 hasAuthorship W4387092024A5004966574 @default.
- W4387092024 hasAuthorship W4387092024A5019258496 @default.
- W4387092024 hasAuthorship W4387092024A5020511633 @default.
- W4387092024 hasAuthorship W4387092024A5028185132 @default.
- W4387092024 hasAuthorship W4387092024A5028206592 @default.
- W4387092024 hasAuthorship W4387092024A5030943230 @default.
- W4387092024 hasAuthorship W4387092024A5037785954 @default.
- W4387092024 hasAuthorship W4387092024A5047626680 @default.
- W4387092024 hasAuthorship W4387092024A5067383538 @default.
- W4387092024 hasAuthorship W4387092024A5070006495 @default.
- W4387092024 hasAuthorship W4387092024A5084376310 @default.
- W4387092024 hasAuthorship W4387092024A5092952439 @default.
- W4387092024 hasConcept C120665830 @default.
- W4387092024 hasConcept C121332964 @default.
- W4387092024 hasConcept C121608353 @default.
- W4387092024 hasConcept C126322002 @default.
- W4387092024 hasConcept C143998085 @default.
- W4387092024 hasConcept C167672396 @default.
- W4387092024 hasConcept C203014093 @default.
- W4387092024 hasConcept C2778424827 @default.
- W4387092024 hasConcept C2779840525 @default.
- W4387092024 hasConcept C2908647359 @default.
- W4387092024 hasConcept C2909287720 @default.
- W4387092024 hasConcept C3013748606 @default.
- W4387092024 hasConcept C3020391436 @default.
- W4387092024 hasConcept C61511704 @default.
- W4387092024 hasConcept C71924100 @default.
- W4387092024 hasConcept C8891405 @default.
- W4387092024 hasConcept C90924648 @default.
- W4387092024 hasConcept C99454951 @default.
- W4387092024 hasConceptScore W4387092024C120665830 @default.
- W4387092024 hasConceptScore W4387092024C121332964 @default.
- W4387092024 hasConceptScore W4387092024C121608353 @default.
- W4387092024 hasConceptScore W4387092024C126322002 @default.
- W4387092024 hasConceptScore W4387092024C143998085 @default.
- W4387092024 hasConceptScore W4387092024C167672396 @default.
- W4387092024 hasConceptScore W4387092024C203014093 @default.
- W4387092024 hasConceptScore W4387092024C2778424827 @default.
- W4387092024 hasConceptScore W4387092024C2779840525 @default.
- W4387092024 hasConceptScore W4387092024C2908647359 @default.
- W4387092024 hasConceptScore W4387092024C2909287720 @default.
- W4387092024 hasConceptScore W4387092024C3013748606 @default.
- W4387092024 hasConceptScore W4387092024C3020391436 @default.
- W4387092024 hasConceptScore W4387092024C61511704 @default.
- W4387092024 hasConceptScore W4387092024C71924100 @default.
- W4387092024 hasConceptScore W4387092024C8891405 @default.
- W4387092024 hasConceptScore W4387092024C90924648 @default.
- W4387092024 hasConceptScore W4387092024C99454951 @default.
- W4387092024 hasLocation W43870920241 @default.
- W4387092024 hasLocation W43870920242 @default.
- W4387092024 hasOpenAccess W4387092024 @default.
- W4387092024 hasPrimaryLocation W43870920241 @default.
- W4387092024 hasRelatedWork W1580426574 @default.
- W4387092024 hasRelatedWork W2089620537 @default.
- W4387092024 hasRelatedWork W2275480158 @default.
- W4387092024 hasRelatedWork W2371214482 @default.
- W4387092024 hasRelatedWork W2374149423 @default.