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- W4387095286 abstract "Retained lead fragments from nonfatal firearm injuries pose a risk of lead poisoning. While chelation is well-established as a lead poisoning treatment, it remains unclear whether chelation mobilizes lead from embedded lead fragments. Here, we tested whether 1) DMSA/succimer or CaNa2EDTA increases mobilization of lead from fragments in vitro, and 2) succimer is efficacious in chelating fragment lead in vivo, using stable lead isotope tracer methods in a rodent model of embedded fragments. DMSA was > 10-times more effective than CaNa2EDTA in mobilizing fragment lead in vitro. In the rodent model, succimer chelation on day 1 produced the greatest blood lead reductions, and fragment lead was not mobilized into blood. However, with continued chelation and over 3-weeks post-chelation, blood lead levels rebounded with mobilization of lead from the fragments. These findings suggest prolonged chelation will increase fragment lead mobilization post-chelation, supporting the need for long-term surveillance in patients with retained fragments." @default.
- W4387095286 created "2023-09-28" @default.
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- W4387095286 date "2023-11-01" @default.
- W4387095286 modified "2023-10-14" @default.
- W4387095286 title "Succimer chelation does not produce lasting reductions of blood lead levels in a rodent model of retained lead fragments" @default.
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- W4387095286 doi "https://doi.org/10.1016/j.etap.2023.104283" @default.
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