FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387097497> ?p ?o ?g. }

• W4387097497 abstract "Abstract Background and Aims: Liver inflammation is important in guiding the initiation of antiviral treatment and affect the disease progression of chronic hepatitis B(CHB). Soluble programmed cell death 1 protein(sPD-1) was upregulated in inflammatory, infectious diseases and correlated with disease severity. We aimed to investigate the correlation between serum sPD-1 and liver inflammation in CHB patients and role in indicating liver inflammation. Methods: 241 CHB patients who underwent a liver biopsy were enrolled. Correlation between sPD-1 levels and the degree of liver inflammation was analyzed. Univariate and multivariate logistic regression were performed to analyze independent variables of severe liver inflammation. Binary logistic regression was conducted to construct the predictive model for severe liver inflammation, and receiver operator characteristic curve(ROC) was used to evaluate the diagnostic accuracy of the predictive model. Results: sPD-1 was the highest in CHB patients with severe liver inflammation, which was higher than that in CHB patients with mild or moderate liver inflammation(P<0.001). Besides, sPD-1 was weakly correlated with AST(r=0.278, P<0.001). Multivariable analysis showed that sPD-1 was an independent predictor of severe liver inflammation. The predictive model contained sPD-1 had an area under the ROC(AUROC) of 0.917 and 0.921 in predicting severe liver inflammation in CHB patients and CHB patients with ALT≤1×upper limit of normal(ULN), respectively. Conclusions: Serum sPD-1 is associated with liver inflammation in CHB patients, and high levels of sPD-1 reflect severe liver inflammation. Serum sPD-1 is an independent predictor of severe liver inflammation and shows improved diagnostic accuracy when combined with other clinical indicators." @default.
• W4387097497 created "2023-09-28" @default.
• W4387097497 creator A5004026570 @default.
• W4387097497 creator A5007774021 @default.
• W4387097497 creator A5010670327 @default.
• W4387097497 creator A5014963018 @default.
• W4387097497 creator A5023606351 @default.
• W4387097497 creator A5028127962 @default.
• W4387097497 creator A5046174516 @default.
• W4387097497 creator A5059632354 @default.
• W4387097497 creator A5061140388 @default.
• W4387097497 creator A5064869771 @default.
• W4387097497 date "2023-09-27" @default.
• W4387097497 modified "2023-09-28" @default.
• W4387097497 title "Soluble programmed cell death 1 protein is a promising biomarker to predict severe liver inflammation in chronic hepatitis B patients" @default.
• W4387097497 cites W1562492193 @default.
• W4387097497 cites W1751697559 @default.
• W4387097497 cites W1949743561 @default.
• W4387097497 cites W1965999622 @default.
• W4387097497 cites W1969776963 @default.
• W4387097497 cites W2049923191 @default.
• W4387097497 cites W2052217197 @default.
• W4387097497 cites W2053366731 @default.
• W4387097497 cites W2081260856 @default.
• W4387097497 cites W2124060252 @default.
• W4387097497 cites W2149479626 @default.
• W4387097497 cites W2155510029 @default.
• W4387097497 cites W2165653319 @default.
• W4387097497 cites W2166093525 @default.
• W4387097497 cites W2218587941 @default.
• W4387097497 cites W2413344701 @default.
• W4387097497 cites W2512352043 @default.
• W4387097497 cites W2553467581 @default.
• W4387097497 cites W2605785536 @default.
• W4387097497 cites W2618952129 @default.
• W4387097497 cites W2619926503 @default.
• W4387097497 cites W2791839818 @default.
• W4387097497 cites W2895545371 @default.
• W4387097497 cites W2895848124 @default.
• W4387097497 cites W2906267046 @default.
• W4387097497 cites W2912069976 @default.
• W4387097497 cites W2961676072 @default.
• W4387097497 cites W2966036367 @default.
• W4387097497 cites W2986291221 @default.
• W4387097497 cites W3023526733 @default.
• W4387097497 cites W3169765227 @default.
• W4387097497 cites W3170775917 @default.
• W4387097497 cites W4200022353 @default.
• W4387097497 cites W4200524321 @default.
• W4387097497 cites W4225473815 @default.
• W4387097497 cites W4229458244 @default.
• W4387097497 cites W4306672691 @default.
• W4387097497 doi "https://doi.org/10.21203/rs.3.rs-3324436/v1" @default.
• W4387097497 hasPublicationYear "2023" @default.
• W4387097497 type Work @default.
• W4387097497 citedByCount "0" @default.
• W4387097497 crossrefType "posted-content" @default.
• W4387097497 hasAuthorship W4387097497A5004026570 @default.
• W4387097497 hasAuthorship W4387097497A5007774021 @default.
• W4387097497 hasAuthorship W4387097497A5010670327 @default.
• W4387097497 hasAuthorship W4387097497A5014963018 @default.
• W4387097497 hasAuthorship W4387097497A5023606351 @default.
• W4387097497 hasAuthorship W4387097497A5028127962 @default.
• W4387097497 hasAuthorship W4387097497A5046174516 @default.
• W4387097497 hasAuthorship W4387097497A5059632354 @default.
• W4387097497 hasAuthorship W4387097497A5061140388 @default.
• W4387097497 hasAuthorship W4387097497A5064869771 @default.
• W4387097497 hasBestOaLocation W43870974971 @default.
• W4387097497 hasConcept C126322002 @default.
• W4387097497 hasConcept C144301174 @default.
• W4387097497 hasConcept C151956035 @default.
• W4387097497 hasConcept C2775934546 @default.
• W4387097497 hasConcept C2776029263 @default.
• W4387097497 hasConcept C2776637226 @default.
• W4387097497 hasConcept C2776914184 @default.
• W4387097497 hasConcept C2777075537 @default.
• W4387097497 hasConcept C2777766500 @default.
• W4387097497 hasConcept C2781197716 @default.
• W4387097497 hasConcept C38180746 @default.
• W4387097497 hasConcept C55493867 @default.
• W4387097497 hasConcept C58471807 @default.
• W4387097497 hasConcept C71924100 @default.
• W4387097497 hasConcept C86803240 @default.
• W4387097497 hasConcept C90924648 @default.
• W4387097497 hasConceptScore W4387097497C126322002 @default.
• W4387097497 hasConceptScore W4387097497C144301174 @default.
• W4387097497 hasConceptScore W4387097497C151956035 @default.
• W4387097497 hasConceptScore W4387097497C2775934546 @default.
• W4387097497 hasConceptScore W4387097497C2776029263 @default.
• W4387097497 hasConceptScore W4387097497C2776637226 @default.
• W4387097497 hasConceptScore W4387097497C2776914184 @default.
• W4387097497 hasConceptScore W4387097497C2777075537 @default.
• W4387097497 hasConceptScore W4387097497C2777766500 @default.
• W4387097497 hasConceptScore W4387097497C2781197716 @default.
• W4387097497 hasConceptScore W4387097497C38180746 @default.
• W4387097497 hasConceptScore W4387097497C55493867 @default.
• W4387097497 hasConceptScore W4387097497C58471807 @default.
• W4387097497 hasConceptScore W4387097497C71924100 @default.
• W4387097497 hasConceptScore W4387097497C86803240 @default.
• W4387097497 hasConceptScore W4387097497C90924648 @default.

• next