Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387098537> ?p ?o ?g. }
- W4387098537 endingPage "2844" @default.
- W4387098537 startingPage "2833" @default.
- W4387098537 abstract "Protein arginine methyltransferase 7 (PRMT7) plays a crucial role in tumor occurrence and development; however, its expression pattern, biological function, and specific mechanism in gastric cancer (GC) remain poorly defined. The present study aimed to investigate the role of PRMT7 during GC carcinogenesis and its underlying mechanism. We found that PRMT7 is expressed at low levels in GC tissues, and this low expression is associated with tumor size, differentiation degree, lymph node metastasis, and TNM stage. Functionally, PRMT7 inhibits GC cell proliferation and migration. Mechanistically, PRMT7 induces PTEN expression and suppresses the downstream PI3K/AKT signaling cascade. Finally, we confirmed that PRMT7 interacts with PTEN protein and promotes PTEN arginine methylation. Taken together, our findings suggest that PRMT7 can inhibit PI3K/AKT signaling pathway activation by regulating PTEN, thereby inhibiting GC cell proliferation and migration. PRMT7 may be a promising therapeutic target for the prevention of GC." @default.
- W4387098537 created "2023-09-28" @default.
- W4387098537 creator A5009439599 @default.
- W4387098537 creator A5015707550 @default.
- W4387098537 creator A5044433615 @default.
- W4387098537 creator A5046135731 @default.
- W4387098537 creator A5082468101 @default.
- W4387098537 date "2023-01-01" @default.
- W4387098537 modified "2023-10-17" @default.
- W4387098537 title "PRMT7 Inhibits the Proliferation and Migration of Gastric Cancer Cells by Suppressing the PI3K/AKT Pathway via PTEN" @default.
- W4387098537 cites W1984621921 @default.
- W4387098537 cites W1988373809 @default.
- W4387098537 cites W2002226709 @default.
- W4387098537 cites W2325135904 @default.
- W4387098537 cites W2429058495 @default.
- W4387098537 cites W2885989996 @default.
- W4387098537 cites W2911631458 @default.
- W4387098537 cites W2917964400 @default.
- W4387098537 cites W2918166828 @default.
- W4387098537 cites W2924530848 @default.
- W4387098537 cites W2938145015 @default.
- W4387098537 cites W2948438687 @default.
- W4387098537 cites W2964804212 @default.
- W4387098537 cites W2984955289 @default.
- W4387098537 cites W2995204555 @default.
- W4387098537 cites W2996498230 @default.
- W4387098537 cites W3000432149 @default.
- W4387098537 cites W3022579309 @default.
- W4387098537 cites W3128646645 @default.
- W4387098537 cites W3129551551 @default.
- W4387098537 cites W3135861642 @default.
- W4387098537 cites W3139197589 @default.
- W4387098537 cites W3163513997 @default.
- W4387098537 cites W3174994934 @default.
- W4387098537 cites W3187817098 @default.
- W4387098537 cites W3203019814 @default.
- W4387098537 cites W3207956872 @default.
- W4387098537 cites W4210828322 @default.
- W4387098537 cites W4210990885 @default.
- W4387098537 cites W4221008878 @default.
- W4387098537 cites W4223515068 @default.
- W4387098537 cites W4225394279 @default.
- W4387098537 cites W4225529913 @default.
- W4387098537 cites W4280607263 @default.
- W4387098537 cites W4309311509 @default.
- W4387098537 doi "https://doi.org/10.7150/jca.88102" @default.
- W4387098537 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37781082" @default.
- W4387098537 hasPublicationYear "2023" @default.
- W4387098537 type Work @default.
- W4387098537 citedByCount "0" @default.
- W4387098537 crossrefType "journal-article" @default.
- W4387098537 hasAuthorship W4387098537A5009439599 @default.
- W4387098537 hasAuthorship W4387098537A5015707550 @default.
- W4387098537 hasAuthorship W4387098537A5044433615 @default.
- W4387098537 hasAuthorship W4387098537A5046135731 @default.
- W4387098537 hasAuthorship W4387098537A5082468101 @default.
- W4387098537 hasBestOaLocation W43870985371 @default.
- W4387098537 hasConcept C104317684 @default.
- W4387098537 hasConcept C111819275 @default.
- W4387098537 hasConcept C121608353 @default.
- W4387098537 hasConcept C185592680 @default.
- W4387098537 hasConcept C2777609662 @default.
- W4387098537 hasConcept C33288867 @default.
- W4387098537 hasConcept C502942594 @default.
- W4387098537 hasConcept C54355233 @default.
- W4387098537 hasConcept C55493867 @default.
- W4387098537 hasConcept C555283112 @default.
- W4387098537 hasConcept C62112901 @default.
- W4387098537 hasConcept C62478195 @default.
- W4387098537 hasConcept C75217442 @default.
- W4387098537 hasConcept C86554907 @default.
- W4387098537 hasConcept C86803240 @default.
- W4387098537 hasConcept C91965660 @default.
- W4387098537 hasConcept C95444343 @default.
- W4387098537 hasConceptScore W4387098537C104317684 @default.
- W4387098537 hasConceptScore W4387098537C111819275 @default.
- W4387098537 hasConceptScore W4387098537C121608353 @default.
- W4387098537 hasConceptScore W4387098537C185592680 @default.
- W4387098537 hasConceptScore W4387098537C2777609662 @default.
- W4387098537 hasConceptScore W4387098537C33288867 @default.
- W4387098537 hasConceptScore W4387098537C502942594 @default.
- W4387098537 hasConceptScore W4387098537C54355233 @default.
- W4387098537 hasConceptScore W4387098537C55493867 @default.
- W4387098537 hasConceptScore W4387098537C555283112 @default.
- W4387098537 hasConceptScore W4387098537C62112901 @default.
- W4387098537 hasConceptScore W4387098537C62478195 @default.
- W4387098537 hasConceptScore W4387098537C75217442 @default.
- W4387098537 hasConceptScore W4387098537C86554907 @default.
- W4387098537 hasConceptScore W4387098537C86803240 @default.
- W4387098537 hasConceptScore W4387098537C91965660 @default.
- W4387098537 hasConceptScore W4387098537C95444343 @default.
- W4387098537 hasIssue "15" @default.
- W4387098537 hasLocation W43870985371 @default.
- W4387098537 hasLocation W43870985372 @default.
- W4387098537 hasOpenAccess W4387098537 @default.
- W4387098537 hasPrimaryLocation W43870985371 @default.
- W4387098537 hasRelatedWork W1988747615 @default.
- W4387098537 hasRelatedWork W1993312761 @default.