Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387102018> ?p ?o ?g. }
- W4387102018 endingPage "14602" @default.
- W4387102018 startingPage "14602" @default.
- W4387102018 abstract "Legionella pneumophila is the primary causative agent of Legionnaires' disease. The mutant-type strain interrupted in the ORF7 gene region responsible for the lipopolysaccharide biosynthesis of the L. pneumophila strain Heysham-1, lacking the O-acetyl groups attached to the rhamnose of the core part, showed a higher surface polarity compared with the wild-type strain. The measurement of excitation energy transfer between fluorophores located on the surface of bacteria and eukaryotic cells showed that, at an early stage of interaction with host cells, the mutant exhibited weaker interactions with Acanthamoeba castellanii cells and THP-1-derived macrophages. The mutant displayed reduced adherence to macrophages but enhanced adherence to A. castellanii, suggesting that the O-acetyl group of the LPS core region plays a crucial role in facilitating interaction with macrophages. The lack of core rhamnose O-acetyl groups made it easier for the bacteria to multiply in amoebae and macrophages. The mutant induced TNF-α production more strongly compared with the wild-type strain. The mutant synthesized twice as many ceramides Cer(t34:0) and Cer(t38:0) than the wild-type strain. The study showed that the internal sugars of the LPS core region of L. pneumophila sg 1 can interact with eukaryotic cell surface receptors and mediate in contacting and attaching bacteria to host cells as well as modulating the immune response to infection." @default.
- W4387102018 created "2023-09-28" @default.
- W4387102018 creator A5011855593 @default.
- W4387102018 creator A5016952614 @default.
- W4387102018 creator A5020961080 @default.
- W4387102018 creator A5034945499 @default.
- W4387102018 creator A5058447684 @default.
- W4387102018 creator A5059098044 @default.
- W4387102018 creator A5062198218 @default.
- W4387102018 creator A5063541844 @default.
- W4387102018 creator A5073499995 @default.
- W4387102018 creator A5076756639 @default.
- W4387102018 creator A5090570934 @default.
- W4387102018 date "2023-09-27" @default.
- W4387102018 modified "2023-10-18" @default.
- W4387102018 title "Lipopolysaccharide of Legionella pneumophila Serogroup 1 Facilitates Interaction with Host Cells" @default.
- W4387102018 cites W137180150 @default.
- W4387102018 cites W1539147750 @default.
- W4387102018 cites W1936705259 @default.
- W4387102018 cites W1963617896 @default.
- W4387102018 cites W1972348350 @default.
- W4387102018 cites W1982443133 @default.
- W4387102018 cites W1988819087 @default.
- W4387102018 cites W1999947108 @default.
- W4387102018 cites W2004583149 @default.
- W4387102018 cites W2013128100 @default.
- W4387102018 cites W2035835006 @default.
- W4387102018 cites W2041505579 @default.
- W4387102018 cites W2043709715 @default.
- W4387102018 cites W2058741484 @default.
- W4387102018 cites W2095506200 @default.
- W4387102018 cites W2097279258 @default.
- W4387102018 cites W2114385318 @default.
- W4387102018 cites W2115421395 @default.
- W4387102018 cites W2115916876 @default.
- W4387102018 cites W2127092072 @default.
- W4387102018 cites W2132396919 @default.
- W4387102018 cites W2135541591 @default.
- W4387102018 cites W2139472905 @default.
- W4387102018 cites W2152127667 @default.
- W4387102018 cites W2152311269 @default.
- W4387102018 cites W2155187758 @default.
- W4387102018 cites W2155676103 @default.
- W4387102018 cites W2164350459 @default.
- W4387102018 cites W2166771178 @default.
- W4387102018 cites W2300552860 @default.
- W4387102018 cites W2584314266 @default.
- W4387102018 cites W2913111334 @default.
- W4387102018 cites W2952744179 @default.
- W4387102018 cites W2959975879 @default.
- W4387102018 cites W2982322669 @default.
- W4387102018 cites W2990421552 @default.
- W4387102018 cites W2996013297 @default.
- W4387102018 cites W3017203947 @default.
- W4387102018 cites W3044917564 @default.
- W4387102018 cites W3048950091 @default.
- W4387102018 cites W3152813579 @default.
- W4387102018 cites W4200576288 @default.
- W4387102018 cites W4224311325 @default.
- W4387102018 cites W4229375955 @default.
- W4387102018 cites W4240882249 @default.
- W4387102018 cites W4253610652 @default.
- W4387102018 doi "https://doi.org/10.3390/ijms241914602" @default.
- W4387102018 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37834049" @default.
- W4387102018 hasPublicationYear "2023" @default.
- W4387102018 type Work @default.
- W4387102018 citedByCount "0" @default.
- W4387102018 crossrefType "journal-article" @default.
- W4387102018 hasAuthorship W4387102018A5011855593 @default.
- W4387102018 hasAuthorship W4387102018A5016952614 @default.
- W4387102018 hasAuthorship W4387102018A5020961080 @default.
- W4387102018 hasAuthorship W4387102018A5034945499 @default.
- W4387102018 hasAuthorship W4387102018A5058447684 @default.
- W4387102018 hasAuthorship W4387102018A5059098044 @default.
- W4387102018 hasAuthorship W4387102018A5062198218 @default.
- W4387102018 hasAuthorship W4387102018A5063541844 @default.
- W4387102018 hasAuthorship W4387102018A5073499995 @default.
- W4387102018 hasAuthorship W4387102018A5076756639 @default.
- W4387102018 hasAuthorship W4387102018A5090570934 @default.
- W4387102018 hasBestOaLocation W43871020181 @default.
- W4387102018 hasConcept C104317684 @default.
- W4387102018 hasConcept C105702510 @default.
- W4387102018 hasConcept C143065580 @default.
- W4387102018 hasConcept C185592680 @default.
- W4387102018 hasConcept C203014093 @default.
- W4387102018 hasConcept C207583985 @default.
- W4387102018 hasConcept C2776118409 @default.
- W4387102018 hasConcept C2778022156 @default.
- W4387102018 hasConcept C2778173381 @default.
- W4387102018 hasConcept C2778754761 @default.
- W4387102018 hasConcept C2779164008 @default.
- W4387102018 hasConcept C2779213145 @default.
- W4387102018 hasConcept C2780295090 @default.
- W4387102018 hasConcept C49039625 @default.
- W4387102018 hasConcept C523546767 @default.
- W4387102018 hasConcept C54355233 @default.
- W4387102018 hasConcept C55493867 @default.
- W4387102018 hasConcept C86803240 @default.