FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387102726> ?p ?o ?g. }

• W4387102726 abstract "ABSTRACT The motility of Vibrio species plays a pivotal role in their survival and adaptation to diverse environments, and is intricately associated with pathogenicity in both humans and aquatic animals. Numerous mutant strains of Vibrio alginolyticus have been generated using UV or EMS mutagenesis to probe flagellar motility using molecular genetic approaches. Identifying these mutations promises to yield valuable insights into motility at the protein structural physiology level. In this study, we conducted an exhaustive analysis of the genomic structures of laboratory Vibrio strains that served as reference specimens. This assemblage notably encompassed the progenitor strain V. alginolyticus 138-2, alongside two strains displaying deficiencies in the lateral flagella (VIO5 and YM4) and one evincing a deficiency in the polar flagella (YM19). Subsequently, we meticulously ascertained the specific mutation sites within the 18 motility-deficient strains whose parents could be traced back to VIO5 or YM4. The identified mutations were conclusively localized within well-established flagella-related genes, providing a coherent rationale for the phenotypic traits exhibited by each motility-deficient mutant. In addition to these motility-related mutations, an average of 20 additional mutations was detected in each mutant strain. Genomic analysis of many mutants is a highly effective tool for comprehensively identifying genes related to specific phenotypes using forward genetics. IMPORTANCE Bacteria of the Vibrio species rely on their motility for survival, adaptation, and pathogenicity. Identifying specific changes in the genome of non-motile mutants can help understand the genes that regulate flagella and motility in these bacteria. Herin, we sequenced the genome of Vibrio alginolyticus 138-2 strain and other motility defective strains and identified most of the mutations to be within genes encoding flagella. Additionally, we also provide a coherent rationale for the motility deficiency in these mutants. We believe that this study could provide a framework for genome sequencing-based methods for studying molecular functions in bacteria." @default.
• W4387102726 created "2023-09-28" @default.
• W4387102726 creator A5013637488 @default.
• W4387102726 creator A5015904741 @default.
• W4387102726 creator A5043714375 @default.
• W4387102726 creator A5054236221 @default.
• W4387102726 creator A5062510801 @default.
• W4387102726 creator A5063474200 @default.
• W4387102726 date "2023-09-26" @default.
• W4387102726 modified "2023-10-06" @default.
• W4387102726 title "Deciphering the Genomes of Motility-Deficient Mutants of<i>Vibrio alginolyticus</i>138-2" @default.
• W4387102726 cites W1499500424 @default.
• W4387102726 cites W1576205762 @default.
• W4387102726 cites W1982855075 @default.
• W4387102726 cites W1990038841 @default.
• W4387102726 cites W1991330646 @default.
• W4387102726 cites W1997329740 @default.
• W4387102726 cites W1997695751 @default.
• W4387102726 cites W2003727205 @default.
• W4387102726 cites W2060466458 @default.
• W4387102726 cites W2068372433 @default.
• W4387102726 cites W2077739444 @default.
• W4387102726 cites W2103441770 @default.
• W4387102726 cites W2117131162 @default.
• W4387102726 cites W2120318998 @default.
• W4387102726 cites W2120902911 @default.
• W4387102726 cites W2122543489 @default.
• W4387102726 cites W2131271579 @default.
• W4387102726 cites W2134718761 @default.
• W4387102726 cites W2143478285 @default.
• W4387102726 cites W2143693701 @default.
• W4387102726 cites W2147984453 @default.
• W4387102726 cites W2161874530 @default.
• W4387102726 cites W2162098634 @default.
• W4387102726 cites W2165621888 @default.
• W4387102726 cites W2166265186 @default.
• W4387102726 cites W2167826782 @default.
• W4387102726 cites W2168133698 @default.
• W4387102726 cites W2170931363 @default.
• W4387102726 cites W2194068775 @default.
• W4387102726 cites W2290768068 @default.
• W4387102726 cites W2318806263 @default.
• W4387102726 cites W2613127536 @default.
• W4387102726 cites W2789843538 @default.
• W4387102726 cites W2793388751 @default.
• W4387102726 cites W2851144202 @default.
• W4387102726 cites W2951912016 @default.
• W4387102726 cites W3007173889 @default.
• W4387102726 cites W3085526196 @default.
• W4387102726 cites W3216289774 @default.
• W4387102726 cites W4285677122 @default.
• W4387102726 cites W4306409918 @default.
• W4387102726 cites W4317475996 @default.
• W4387102726 cites W4318020103 @default.
• W4387102726 cites W4322757129 @default.
• W4387102726 doi "https://doi.org/10.1101/2023.09.26.559574" @default.
• W4387102726 hasPublicationYear "2023" @default.
• W4387102726 type Work @default.
• W4387102726 citedByCount "0" @default.
• W4387102726 crossrefType "posted-content" @default.
• W4387102726 hasAuthorship W4387102726A5013637488 @default.
• W4387102726 hasAuthorship W4387102726A5015904741 @default.
• W4387102726 hasAuthorship W4387102726A5043714375 @default.
• W4387102726 hasAuthorship W4387102726A5054236221 @default.
• W4387102726 hasAuthorship W4387102726A5062510801 @default.
• W4387102726 hasAuthorship W4387102726A5063474200 @default.
• W4387102726 hasBestOaLocation W43871027261 @default.
• W4387102726 hasConcept C104317684 @default.
• W4387102726 hasConcept C115811362 @default.
• W4387102726 hasConcept C127716648 @default.
• W4387102726 hasConcept C141231307 @default.
• W4387102726 hasConcept C143065580 @default.
• W4387102726 hasConcept C16318435 @default.
• W4387102726 hasConcept C2776154503 @default.
• W4387102726 hasConcept C2778968793 @default.
• W4387102726 hasConcept C501734568 @default.
• W4387102726 hasConcept C523546767 @default.
• W4387102726 hasConcept C54355233 @default.
• W4387102726 hasConcept C58207958 @default.
• W4387102726 hasConcept C60987743 @default.
• W4387102726 hasConcept C86803240 @default.
• W4387102726 hasConcept C89423630 @default.
• W4387102726 hasConceptScore W4387102726C104317684 @default.
• W4387102726 hasConceptScore W4387102726C115811362 @default.
• W4387102726 hasConceptScore W4387102726C127716648 @default.
• W4387102726 hasConceptScore W4387102726C141231307 @default.
• W4387102726 hasConceptScore W4387102726C143065580 @default.
• W4387102726 hasConceptScore W4387102726C16318435 @default.
• W4387102726 hasConceptScore W4387102726C2776154503 @default.
• W4387102726 hasConceptScore W4387102726C2778968793 @default.
• W4387102726 hasConceptScore W4387102726C501734568 @default.
• W4387102726 hasConceptScore W4387102726C523546767 @default.
• W4387102726 hasConceptScore W4387102726C54355233 @default.
• W4387102726 hasConceptScore W4387102726C58207958 @default.
• W4387102726 hasConceptScore W4387102726C60987743 @default.
• W4387102726 hasConceptScore W4387102726C86803240 @default.
• W4387102726 hasConceptScore W4387102726C89423630 @default.
• W4387102726 hasLocation W43871027261 @default.
• W4387102726 hasOpenAccess W4387102726 @default.
• W4387102726 hasPrimaryLocation W43871027261 @default.

• next