Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387103312> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W4387103312 endingPage "e32" @default.
- W4387103312 startingPage "e32" @default.
- W4387103312 abstract "Resistance to anti-tuberculosis drugs, especially ethambutol (EMB), has been widely reported worldwide. EMB resistance is caused by mutations in the embB gene, which encodes the arabinosyl transferase enzyme. This study aimed to detect mutations in the embB gene of Mycobacterium tuberculosis from Papua and to evaluate their impact on the effectiveness of EMB. We analyzed 20 samples of M. tuberculosis culture that had undergone whole-genome sequencing, of which 19 samples were of sufficient quality for further bioinformatics analysis. Mutation analysis was performed using TBProfiler, which identified M306L, M306V, D1024N, and E378A mutations. In sample TB035, the M306L mutation was present along with E378A. The binding affinity of EMB to arabinosyl transferase was calculated using AutoDock Vina. The molecular docking results revealed that all mutants demonstrated an increased binding affinity to EMB compared to the native protein (-0.948 kcal/mol). The presence of the M306L mutation, when coexisting with E378A, resulted in a slight increase in binding affinity compared to the M306L mutation alone. The molecular dynamics simulation results indicated that the M306L, M306L + E378A, M306V, and E378A mutants decreased protein stability. Conversely, the D1024N mutant exhibited stability comparable to the native protein. In conclusion, this study suggests that the M306L, M306L + E378A, M306V, and E378A mutations may contribute to EMB resistance, while the D1024N mutation may be consistent with continued susceptibility to EMB." @default.
- W4387103312 created "2023-09-28" @default.
- W4387103312 creator A5060273304 @default.
- W4387103312 creator A5076016262 @default.
- W4387103312 creator A5083999961 @default.
- W4387103312 date "2023-09-30" @default.
- W4387103312 modified "2023-10-11" @default.
- W4387103312 title "Structural dynamics insights into the M306L, M306V, and D1024N mutations in Mycobacterium tuberculosis inducing resistance to ethambutol" @default.
- W4387103312 cites W1031578623 @default.
- W4387103312 cites W1935845864 @default.
- W4387103312 cites W1985588649 @default.
- W4387103312 cites W2021520922 @default.
- W4387103312 cites W2023490488 @default.
- W4387103312 cites W2028046413 @default.
- W4387103312 cites W2058417246 @default.
- W4387103312 cites W2089685396 @default.
- W4387103312 cites W2101478678 @default.
- W4387103312 cites W2115294037 @default.
- W4387103312 cites W2118374299 @default.
- W4387103312 cites W2136380288 @default.
- W4387103312 cites W2145407927 @default.
- W4387103312 cites W2148922378 @default.
- W4387103312 cites W2150863863 @default.
- W4387103312 cites W2151436508 @default.
- W4387103312 cites W2156298917 @default.
- W4387103312 cites W2158023121 @default.
- W4387103312 cites W2166566986 @default.
- W4387103312 cites W2206954826 @default.
- W4387103312 cites W2265245360 @default.
- W4387103312 cites W2461183954 @default.
- W4387103312 cites W2555870966 @default.
- W4387103312 cites W2809418964 @default.
- W4387103312 cites W2934655292 @default.
- W4387103312 cites W2952463453 @default.
- W4387103312 cites W2999857229 @default.
- W4387103312 cites W3009469344 @default.
- W4387103312 cites W3022055142 @default.
- W4387103312 cites W3048707618 @default.
- W4387103312 cites W3215222034 @default.
- W4387103312 cites W4210263858 @default.
- W4387103312 cites W4226424306 @default.
- W4387103312 doi "https://doi.org/10.5808/gi.23019" @default.
- W4387103312 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37813628" @default.
- W4387103312 hasPublicationYear "2023" @default.
- W4387103312 type Work @default.
- W4387103312 citedByCount "0" @default.
- W4387103312 crossrefType "journal-article" @default.
- W4387103312 hasAuthorship W4387103312A5060273304 @default.
- W4387103312 hasAuthorship W4387103312A5076016262 @default.
- W4387103312 hasAuthorship W4387103312A5083999961 @default.
- W4387103312 hasBestOaLocation W43871033121 @default.
- W4387103312 hasConcept C104317684 @default.
- W4387103312 hasConcept C114851261 @default.
- W4387103312 hasConcept C142724271 @default.
- W4387103312 hasConcept C143065580 @default.
- W4387103312 hasConcept C153911025 @default.
- W4387103312 hasConcept C2776228421 @default.
- W4387103312 hasConcept C2777975735 @default.
- W4387103312 hasConcept C2781069245 @default.
- W4387103312 hasConcept C2994225774 @default.
- W4387103312 hasConcept C501734568 @default.
- W4387103312 hasConcept C54355233 @default.
- W4387103312 hasConcept C71924100 @default.
- W4387103312 hasConcept C86803240 @default.
- W4387103312 hasConceptScore W4387103312C104317684 @default.
- W4387103312 hasConceptScore W4387103312C114851261 @default.
- W4387103312 hasConceptScore W4387103312C142724271 @default.
- W4387103312 hasConceptScore W4387103312C143065580 @default.
- W4387103312 hasConceptScore W4387103312C153911025 @default.
- W4387103312 hasConceptScore W4387103312C2776228421 @default.
- W4387103312 hasConceptScore W4387103312C2777975735 @default.
- W4387103312 hasConceptScore W4387103312C2781069245 @default.
- W4387103312 hasConceptScore W4387103312C2994225774 @default.
- W4387103312 hasConceptScore W4387103312C501734568 @default.
- W4387103312 hasConceptScore W4387103312C54355233 @default.
- W4387103312 hasConceptScore W4387103312C71924100 @default.
- W4387103312 hasConceptScore W4387103312C86803240 @default.
- W4387103312 hasIssue "3" @default.
- W4387103312 hasLocation W43871033121 @default.
- W4387103312 hasLocation W43871033122 @default.
- W4387103312 hasOpenAccess W4387103312 @default.
- W4387103312 hasPrimaryLocation W43871033121 @default.
- W4387103312 hasRelatedWork W2059563976 @default.
- W4387103312 hasRelatedWork W2110949356 @default.
- W4387103312 hasRelatedWork W2148466251 @default.
- W4387103312 hasRelatedWork W2152075272 @default.
- W4387103312 hasRelatedWork W2362774094 @default.
- W4387103312 hasRelatedWork W2392748791 @default.
- W4387103312 hasRelatedWork W2546518088 @default.
- W4387103312 hasRelatedWork W2972094210 @default.
- W4387103312 hasRelatedWork W3143090593 @default.
- W4387103312 hasRelatedWork W4308058527 @default.
- W4387103312 hasVolume "21" @default.
- W4387103312 isParatext "false" @default.
- W4387103312 isRetracted "false" @default.
- W4387103312 workType "article" @default.