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• W4387105816 abstract "Abstract Psychedelic therapy (PT) is an emerging paradigm with great transdiagnostic potential for treating psychiatric disorders, including depression, addiction, post-traumatic stress disorder, and potentially others. ‘Classic’ serotonergic psychedelics, such as psilocybin and lysergic acid diethylamide (LSD), which have a key locus of action at the 5-HT2A receptor, form the main focus of this movement, but substances including ketamine, 3,4-Methylenedioxymethamphetamine (MDMA) and ibogaine also hold promise. The modern phase of development of these treatment modalities in the early 21st century has occurred concurrently with the wider use of advanced human neuroscientific research methods; principally neuroimaging. This can potentially enable assessment of drug and therapy brain effects with greater precision and quantification than any previous novel development in psychiatric pharmacology. We outline the major trends in existing data and suggest the modern development of PT has benefitted greatly from the use of neuroimaging. Important gaps in existing knowledge are identified, namely: the relationship between acute drug effects and longer-term (clinically-relevant) effects, the precise characterisation of effects at the 5-HT2A receptor and relationships with functional/clinical effects, and the possible impact of these compounds on neuroplasticity. A road-map for future research is laid out, outlining clinical studies which will directly address these three questions, principally using combined Positron Emission Tomography (PET) and Magnetic Resonance Imaging (MRI) methods, plus other adjunct techniques. Multimodal (PET/MRI) studies using modern PET techniques such as the 5-HT2A-selective ligand [11 C]Cimbi-36 (and other ligands sensitive to neuroplasticity changes) alongside MRI measures of brain function would provide a ‘molecular-functional-clinical bridge’ in understanding. Such results would help to resolve some of these questions and provide a firmer foundation for the ongoing development of PT." @default.
• W4387105816 created "2023-09-28" @default.
• W4387105816 creator A5005098704 @default.
• W4387105816 creator A5030356455 @default.
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• W4387105816 creator A5037416115 @default.
• W4387105816 creator A5044907549 @default.
• W4387105816 creator A5069665617 @default.
• W4387105816 date "2023-09-27" @default.
• W4387105816 modified "2023-10-17" @default.
• W4387105816 title "Neuroimaging in psychedelic drug development: past, present, and future" @default.
• W4387105816 cites W1052224991 @default.
• W4387105816 cites W1489278735 @default.
• W4387105816 cites W1496288922 @default.
• W4387105816 cites W1520852255 @default.
• W4387105816 cites W1968349239 @default.
• W4387105816 cites W1978543620 @default.
• W4387105816 cites W1984742243 @default.
• W4387105816 cites W1986425243 @default.
• W4387105816 cites W1993983615 @default.
• W4387105816 cites W1995045083 @default.
• W4387105816 cites W1997058647 @default.
• W4387105816 cites W2003861703 @default.
• W4387105816 cites W2011224808 @default.
• W4387105816 cites W2015641758 @default.
• W4387105816 cites W2017046927 @default.
• W4387105816 cites W2017360110 @default.
• W4387105816 cites W2026832357 @default.
• W4387105816 cites W2035478469 @default.
• W4387105816 cites W2058298068 @default.
• W4387105816 cites W2060895955 @default.
• W4387105816 cites W2064685959 @default.
• W4387105816 cites W2068427049 @default.
• W4387105816 cites W2074647482 @default.
• W4387105816 cites W2077885318 @default.
• W4387105816 cites W2079106221 @default.
• W4387105816 cites W2087848624 @default.
• W4387105816 cites W2089149909 @default.
• W4387105816 cites W2097563002 @default.
• W4387105816 cites W2099401653 @default.
• W4387105816 cites W2102963347 @default.
• W4387105816 cites W2107788476 @default.
• W4387105816 cites W2122127415 @default.
• W4387105816 cites W2124413615 @default.
• W4387105816 cites W2126561556 @default.
• W4387105816 cites W2132116042 @default.
• W4387105816 cites W2155757287 @default.
• W4387105816 cites W2164282704 @default.
• W4387105816 cites W2171104921 @default.
• W4387105816 cites W2171603114 @default.
• W4387105816 cites W2175115710 @default.
• W4387105816 cites W2336389811 @default.
• W4387105816 cites W2336591896 @default.
• W4387105816 cites W2337964085 @default.
• W4387105816 cites W2396675581 @default.
• W4387105816 cites W2439685582 @default.
• W4387105816 cites W2468366067 @default.
• W4387105816 cites W2503767557 @default.
• W4387105816 cites W2543481269 @default.
• W4387105816 cites W2543692442 @default.
• W4387105816 cites W2567295262 @default.
• W4387105816 cites W2602495892 @default.
• W4387105816 cites W2667975260 @default.
• W4387105816 cites W2727788737 @default.
• W4387105816 cites W2733751315 @default.
• W4387105816 cites W2753654430 @default.
• W4387105816 cites W2762746674 @default.
• W4387105816 cites W2781316183 @default.
• W4387105816 cites W2781340150 @default.
• W4387105816 cites W2784340661 @default.
• W4387105816 cites W2798279033 @default.
• W4387105816 cites W2800610744 @default.
• W4387105816 cites W2801890140 @default.
• W4387105816 cites W2810589755 @default.
• W4387105816 cites W2883640374 @default.
• W4387105816 cites W2886249511 @default.
• W4387105816 cites W2898717395 @default.
• W4387105816 cites W2914255920 @default.
• W4387105816 cites W2948924404 @default.
• W4387105816 cites W2949457836 @default.
• W4387105816 cites W2950564037 @default.
• W4387105816 cites W2962285119 @default.
• W4387105816 cites W2963170513 @default.
• W4387105816 cites W2964032412 @default.
• W4387105816 cites W2983974020 @default.
• W4387105816 cites W2996321268 @default.
• W4387105816 cites W2999279320 @default.
• W4387105816 cites W3000549374 @default.
• W4387105816 cites W3005441929 @default.
• W4387105816 cites W3009076589 @default.
• W4387105816 cites W3031742716 @default.
• W4387105816 cites W3082850425 @default.
• W4387105816 cites W3091936754 @default.
• W4387105816 cites W3092444467 @default.
• W4387105816 cites W3096208965 @default.
• W4387105816 cites W3110820786 @default.
• W4387105816 cites W3112173414 @default.
• W4387105816 cites W3112909063 @default.
• W4387105816 cites W3118379705 @default.
• W4387105816 cites W3153638782 @default.

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