Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387106640> ?p ?o ?g. }
- W4387106640 endingPage "1375" @default.
- W4387106640 startingPage "1375" @default.
- W4387106640 abstract "Background: Endocannabinoids and related N-acylethanolamines (NAEs) are bioactive lipids with important physiological functions and putative roles in mental health and addictions. Although chronic cannabis use is associated with endocannabinoid system changes, the status of circulating endocannabinoids and related NAEs in people with cannabis use disorder (CUD) is uncertain. Methods: Eleven individuals with CUD and 54 healthy non-cannabis using control participants (HC) provided plasma for measurement by high-performance liquid chromatography–mass spectrometry of endocannabinoids (2-arachidonoylglycerol (2-AG) and N-arachidonoylethanolamine (AEA)) and related NAE fatty acids (N-docosahexaenoylethanolamine (DHEA) and N-oleoylethanolamine (OEA)). Participants were genotyped for the functional gene variant of FAAH (rs324420, C385A) which may affect concentrations of AEA as well as other NAEs (OEA, DHEA). Results: In overnight abstinent CUD, AEA, OEA and DHEA concentrations were significantly higher (31–40%; p < 0.05) and concentrations of the endocannabinoid 2-AG were marginally elevated (55%, p = 0.13) relative to HC. There were no significant correlations between endocannabinoids/NAE concentrations and cannabis analytes, self-reported cannabis use frequency or withdrawal symptoms. DHEA concentration was inversely related with marijuana craving (r = −0.86; p = 0.001). Genotype had no significant effect on plasma endocannabinoids/NAE concentrations. Conclusions: Our preliminary findings, requiring replication, might suggest that activity of the endocannabinoid system is elevated in chronic cannabis users. It is unclear whether this elevation is a compensatory response or a predating state. Studies examining endocannabinoids and NAEs during prolonged abstinence as well as the potential role of DHEA in craving are warranted." @default.
- W4387106640 created "2023-09-28" @default.
- W4387106640 creator A5000016116 @default.
- W4387106640 creator A5000210550 @default.
- W4387106640 creator A5015860750 @default.
- W4387106640 creator A5019986083 @default.
- W4387106640 creator A5027044666 @default.
- W4387106640 creator A5027965558 @default.
- W4387106640 creator A5036295499 @default.
- W4387106640 creator A5040666465 @default.
- W4387106640 creator A5046628089 @default.
- W4387106640 creator A5060841302 @default.
- W4387106640 creator A5063108898 @default.
- W4387106640 creator A5063648717 @default.
- W4387106640 date "2023-09-27" @default.
- W4387106640 modified "2023-09-28" @default.
- W4387106640 title "Circulating Endocannabinoids and N-Acylethanolamines in Individuals with Cannabis Use Disorder—Preliminary Findings" @default.
- W4387106640 cites W1488329806 @default.
- W4387106640 cites W1525045334 @default.
- W4387106640 cites W1605113209 @default.
- W4387106640 cites W1785252265 @default.
- W4387106640 cites W1948760417 @default.
- W4387106640 cites W1967119923 @default.
- W4387106640 cites W1970307887 @default.
- W4387106640 cites W1974532623 @default.
- W4387106640 cites W1974852599 @default.
- W4387106640 cites W1977165453 @default.
- W4387106640 cites W1978307963 @default.
- W4387106640 cites W1979315934 @default.
- W4387106640 cites W1983215698 @default.
- W4387106640 cites W1989073099 @default.
- W4387106640 cites W2002535987 @default.
- W4387106640 cites W2003159048 @default.
- W4387106640 cites W2003561040 @default.
- W4387106640 cites W2006062215 @default.
- W4387106640 cites W2025437677 @default.
- W4387106640 cites W2027835625 @default.
- W4387106640 cites W2039516936 @default.
- W4387106640 cites W2040077055 @default.
- W4387106640 cites W2047244415 @default.
- W4387106640 cites W2051741667 @default.
- W4387106640 cites W2052794650 @default.
- W4387106640 cites W2059254350 @default.
- W4387106640 cites W2062181435 @default.
- W4387106640 cites W2067495470 @default.
- W4387106640 cites W2067683495 @default.
- W4387106640 cites W2067705047 @default.
- W4387106640 cites W2075282427 @default.
- W4387106640 cites W2075894678 @default.
- W4387106640 cites W2077169466 @default.
- W4387106640 cites W2085741941 @default.
- W4387106640 cites W2089244898 @default.
- W4387106640 cites W2090705977 @default.
- W4387106640 cites W2097747770 @default.
- W4387106640 cites W2098853434 @default.
- W4387106640 cites W2104652079 @default.
- W4387106640 cites W2111728944 @default.
- W4387106640 cites W2113545425 @default.
- W4387106640 cites W2119758521 @default.
- W4387106640 cites W2131897052 @default.
- W4387106640 cites W2141343547 @default.
- W4387106640 cites W2141551684 @default.
- W4387106640 cites W2143264078 @default.
- W4387106640 cites W2150821313 @default.
- W4387106640 cites W2154855551 @default.
- W4387106640 cites W2157501942 @default.
- W4387106640 cites W2167845627 @default.
- W4387106640 cites W2171396692 @default.
- W4387106640 cites W2171503950 @default.
- W4387106640 cites W2286619620 @default.
- W4387106640 cites W2322180695 @default.
- W4387106640 cites W2344299676 @default.
- W4387106640 cites W2522874465 @default.
- W4387106640 cites W2526667480 @default.
- W4387106640 cites W2612325272 @default.
- W4387106640 cites W2725622653 @default.
- W4387106640 cites W2775395495 @default.
- W4387106640 cites W2902311239 @default.
- W4387106640 cites W2908582841 @default.
- W4387106640 cites W2968306934 @default.
- W4387106640 cites W2996080671 @default.
- W4387106640 cites W2997801845 @default.
- W4387106640 cites W3089317890 @default.
- W4387106640 cites W3131397527 @default.
- W4387106640 cites W3138143309 @default.
- W4387106640 cites W4220797312 @default.
- W4387106640 cites W4225083961 @default.
- W4387106640 cites W4229446974 @default.
- W4387106640 cites W4281567095 @default.
- W4387106640 cites W4308834593 @default.
- W4387106640 cites W4315754522 @default.
- W4387106640 doi "https://doi.org/10.3390/brainsci13101375" @default.
- W4387106640 hasPublicationYear "2023" @default.
- W4387106640 type Work @default.
- W4387106640 citedByCount "0" @default.
- W4387106640 crossrefType "journal-article" @default.
- W4387106640 hasAuthorship W4387106640A5000016116 @default.
- W4387106640 hasAuthorship W4387106640A5000210550 @default.