Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387106834> ?p ?o ?g. }
- W4387106834 abstract "Exchange of genetic material through sexual reproduction or horizontal gene transfer is ubiquitous in nature. Among the few outliers that rarely recombine and mainly evolve by de novo mutation are a group of deadly bacterial pathogens, including the causative agents of leprosy, plague, typhoid, and tuberculosis. The interplay of evolutionary processes is poorly understood in these organisms. Population genetic methods allowing to infer mutation, recombination, genetic drift, and natural selection make strong assumptions that are difficult to reconcile with clonal reproduction and fully linked genomes consisting mainly of coding regions. In this review, we highlight the challenges of extreme clonality by discussing population genetic inference with the Mycobacterium tuberculosis complex, a group of closely related obligate bacterial pathogens of mammals. We show how uncertainties underlying quantitative models and verbal arguments affect previous conclusions about the way these organisms evolve. A question mark remains behind various quantities of applied and theoretical interest, including mutation rates, the interpretation of nonsynonymous polymorphisms, or the role of genetic bottlenecks. Looking ahead, we discuss how new tools for evolutionary simulations, going beyond the traditional Wright-Fisher framework, promise a more rigorous treatment of basic evolutionary processes in clonal bacteria." @default.
- W4387106834 created "2023-09-28" @default.
- W4387106834 creator A5030164695 @default.
- W4387106834 creator A5081756586 @default.
- W4387106834 date "2023-09-27" @default.
- W4387106834 modified "2023-10-07" @default.
- W4387106834 title "How do monomorphic bacteria evolve? The Mycobacterium tuberculosis complex and the awkward population genetics of extreme clonality" @default.
- W4387106834 cites W1561849362 @default.
- W4387106834 cites W1563635490 @default.
- W4387106834 cites W1772281102 @default.
- W4387106834 cites W1833387197 @default.
- W4387106834 cites W1963900359 @default.
- W4387106834 cites W1965293597 @default.
- W4387106834 cites W1967585857 @default.
- W4387106834 cites W1968179480 @default.
- W4387106834 cites W1985986410 @default.
- W4387106834 cites W1992027784 @default.
- W4387106834 cites W1992663777 @default.
- W4387106834 cites W1997898977 @default.
- W4387106834 cites W1999286199 @default.
- W4387106834 cites W2000063205 @default.
- W4387106834 cites W2002363009 @default.
- W4387106834 cites W2003025878 @default.
- W4387106834 cites W2005360702 @default.
- W4387106834 cites W2005412543 @default.
- W4387106834 cites W2007707812 @default.
- W4387106834 cites W2012577134 @default.
- W4387106834 cites W2014300152 @default.
- W4387106834 cites W2015358533 @default.
- W4387106834 cites W2023304660 @default.
- W4387106834 cites W2024018864 @default.
- W4387106834 cites W2030009629 @default.
- W4387106834 cites W2032694101 @default.
- W4387106834 cites W2038662463 @default.
- W4387106834 cites W2043532115 @default.
- W4387106834 cites W2043926219 @default.
- W4387106834 cites W2045716211 @default.
- W4387106834 cites W2046793790 @default.
- W4387106834 cites W2046956642 @default.
- W4387106834 cites W2052903982 @default.
- W4387106834 cites W2055861579 @default.
- W4387106834 cites W2056981303 @default.
- W4387106834 cites W2058607113 @default.
- W4387106834 cites W2062210712 @default.
- W4387106834 cites W2063263897 @default.
- W4387106834 cites W2066093582 @default.
- W4387106834 cites W2071490229 @default.
- W4387106834 cites W2072550492 @default.
- W4387106834 cites W2074456979 @default.
- W4387106834 cites W2083539954 @default.
- W4387106834 cites W2086067658 @default.
- W4387106834 cites W2093323099 @default.
- W4387106834 cites W2100238259 @default.
- W4387106834 cites W2102075559 @default.
- W4387106834 cites W2102302276 @default.
- W4387106834 cites W2102692786 @default.
- W4387106834 cites W2105341822 @default.
- W4387106834 cites W2106813347 @default.
- W4387106834 cites W2107303144 @default.
- W4387106834 cites W2107514803 @default.
- W4387106834 cites W2107828572 @default.
- W4387106834 cites W2108638835 @default.
- W4387106834 cites W2110129027 @default.
- W4387106834 cites W2110150994 @default.
- W4387106834 cites W2110335151 @default.
- W4387106834 cites W2111159572 @default.
- W4387106834 cites W2113055661 @default.
- W4387106834 cites W2115453787 @default.
- W4387106834 cites W2115622704 @default.
- W4387106834 cites W2116111392 @default.
- W4387106834 cites W2119125893 @default.
- W4387106834 cites W2129163909 @default.
- W4387106834 cites W2130315111 @default.
- W4387106834 cites W2137120669 @default.
- W4387106834 cites W2137478816 @default.
- W4387106834 cites W2140425076 @default.
- W4387106834 cites W2142410038 @default.
- W4387106834 cites W2143431740 @default.
- W4387106834 cites W2143718468 @default.
- W4387106834 cites W2144368480 @default.
- W4387106834 cites W2147571700 @default.
- W4387106834 cites W2148734328 @default.
- W4387106834 cites W2150600032 @default.
- W4387106834 cites W2153953403 @default.
- W4387106834 cites W2158023121 @default.
- W4387106834 cites W2164217177 @default.
- W4387106834 cites W2165206297 @default.
- W4387106834 cites W2169720428 @default.
- W4387106834 cites W2170093840 @default.
- W4387106834 cites W2171598486 @default.
- W4387106834 cites W2172569011 @default.
- W4387106834 cites W2202834013 @default.
- W4387106834 cites W2255134164 @default.
- W4387106834 cites W2279580203 @default.
- W4387106834 cites W2289445866 @default.
- W4387106834 cites W2340203382 @default.
- W4387106834 cites W2466909028 @default.
- W4387106834 cites W2517845626 @default.
- W4387106834 cites W2536215034 @default.
- W4387106834 cites W2563526198 @default.