Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387107974> ?p ?o ?g. }
- W4387107974 endingPage "176061" @default.
- W4387107974 startingPage "176061" @default.
- W4387107974 abstract "Coronavirus disease 2019 (COVID-19) has been declared a new pandemic in March 2020. Although most patients are asymptomatic, those with underlying cardiovascular comorbidities may develop a more severe systemic infection which is often associated with fatal pneumonia. Nonetheless, neurological and cardiovascular manifestations could be present even without respiratory symptoms. To date, no COVID-19-specific drugs are able for preventing or treating the infection and generally, the symptoms are relieved with general anti-inflammatory drugs. Angiotensin-converting-enzyme 2 (ACE2) may function as the receptor for virus entry within the cells favoring the progression of infection in the organism. On the other hand, ACE2 is a relevant enzyme in renin angiotensin system (RAS) cascade fostering Ang1-7/Mas receptor activation which promotes protective effects in neurological and cardiovascular systems. It is known that RAS is composed by two functional countervailing axes the ACE/AngII/AT1 receptor and the ACE/AngII/AT2 receptor which counteracts the actions mediated by AngII/AT1 receptor by inducing anti-inflammatory, antioxidant and anti-growth functions. Subsequently an “alternative” ACE2/Ang1-7/Mas receptor axis has been described with functions similar to the latter protective arm. Here, we discuss the neurological and cardiovascular effects of COVID-19 highlighting the role of the stimulation of the RAS “alternative” protective arm in attenuating pulmonary, cerebral and cardiovascular damages. In conclusion, only two clinical trials are running for Mas receptor agonists but few other molecules are in preclinical phase and if successful these drugs might represent a successful strategy for the treatment of the acute phase of COVID-19 infection." @default.
- W4387107974 created "2023-09-28" @default.
- W4387107974 creator A5020814480 @default.
- W4387107974 creator A5029321754 @default.
- W4387107974 creator A5029889770 @default.
- W4387107974 creator A5031769855 @default.
- W4387107974 creator A5032007978 @default.
- W4387107974 creator A5064998679 @default.
- W4387107974 creator A5082001767 @default.
- W4387107974 date "2023-11-01" @default.
- W4387107974 modified "2023-10-11" @default.
- W4387107974 title "From cardiovascular system to brain, the potential protective role of mas receptors in COVID-19 infection." @default.
- W4387107974 cites W1485797085 @default.
- W4387107974 cites W1501390797 @default.
- W4387107974 cites W1538839647 @default.
- W4387107974 cites W1581300995 @default.
- W4387107974 cites W1594981111 @default.
- W4387107974 cites W1951245962 @default.
- W4387107974 cites W1970527112 @default.
- W4387107974 cites W1970643176 @default.
- W4387107974 cites W1976319679 @default.
- W4387107974 cites W1980434555 @default.
- W4387107974 cites W1980437561 @default.
- W4387107974 cites W1982533785 @default.
- W4387107974 cites W1991841545 @default.
- W4387107974 cites W1995952126 @default.
- W4387107974 cites W2001788362 @default.
- W4387107974 cites W2002928279 @default.
- W4387107974 cites W2007178349 @default.
- W4387107974 cites W2007361910 @default.
- W4387107974 cites W2009170528 @default.
- W4387107974 cites W2012405903 @default.
- W4387107974 cites W2015386277 @default.
- W4387107974 cites W2016107840 @default.
- W4387107974 cites W2020834404 @default.
- W4387107974 cites W2025672718 @default.
- W4387107974 cites W2028417220 @default.
- W4387107974 cites W2028521865 @default.
- W4387107974 cites W2032062610 @default.
- W4387107974 cites W2034426742 @default.
- W4387107974 cites W2039223857 @default.
- W4387107974 cites W2044422062 @default.
- W4387107974 cites W2046254616 @default.
- W4387107974 cites W2050496951 @default.
- W4387107974 cites W2053816356 @default.
- W4387107974 cites W2059287255 @default.
- W4387107974 cites W2061241639 @default.
- W4387107974 cites W2070459088 @default.
- W4387107974 cites W2070463916 @default.
- W4387107974 cites W2075550688 @default.
- W4387107974 cites W2082133861 @default.
- W4387107974 cites W2083529118 @default.
- W4387107974 cites W2085250186 @default.
- W4387107974 cites W2085864105 @default.
- W4387107974 cites W2096665985 @default.
- W4387107974 cites W2099008038 @default.
- W4387107974 cites W2100104153 @default.
- W4387107974 cites W2101075976 @default.
- W4387107974 cites W2101176145 @default.
- W4387107974 cites W2105161414 @default.
- W4387107974 cites W2109740270 @default.
- W4387107974 cites W2111584700 @default.
- W4387107974 cites W2112430900 @default.
- W4387107974 cites W2117758586 @default.
- W4387107974 cites W2122411629 @default.
- W4387107974 cites W2127470172 @default.
- W4387107974 cites W2128651238 @default.
- W4387107974 cites W2131748151 @default.
- W4387107974 cites W2132224038 @default.
- W4387107974 cites W2132483044 @default.
- W4387107974 cites W2133171760 @default.
- W4387107974 cites W2135274101 @default.
- W4387107974 cites W2135832604 @default.
- W4387107974 cites W2137225581 @default.
- W4387107974 cites W2141671076 @default.
- W4387107974 cites W2146131666 @default.
- W4387107974 cites W2146490898 @default.
- W4387107974 cites W2150193183 @default.
- W4387107974 cites W2150649236 @default.
- W4387107974 cites W2151150148 @default.
- W4387107974 cites W2151190145 @default.
- W4387107974 cites W2151622529 @default.
- W4387107974 cites W2159872857 @default.
- W4387107974 cites W2160829270 @default.
- W4387107974 cites W2161091338 @default.
- W4387107974 cites W2161150359 @default.
- W4387107974 cites W2161399617 @default.
- W4387107974 cites W2161477365 @default.
- W4387107974 cites W2161930158 @default.
- W4387107974 cites W2163395116 @default.
- W4387107974 cites W2164686130 @default.
- W4387107974 cites W2167369100 @default.
- W4387107974 cites W2167384912 @default.
- W4387107974 cites W2168194361 @default.
- W4387107974 cites W2168580426 @default.
- W4387107974 cites W2168782395 @default.
- W4387107974 cites W2259233326 @default.
- W4387107974 cites W2317678845 @default.