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• W4387108229 endingPage "107114" @default.
• W4387108229 startingPage "107114" @default.
• W4387108229 abstract "Nitric oxide (NO) is known to be an important regulator of neurological processes in the central nervous system which acts directly on the presynaptic neuron and enhances the release of neurotransmitters like glutamate into the synaptic cleft. Calcium influx activates a cascade of biochemical reactions to influence the production of nitric oxide in the postsynaptic neuron. This has been modeled in the present work as a system of ordinary differential equations, to explore the dynamics of the interacting components and predict the dynamical behavior of the postsynaptic neuron. It has been hypothesized that nitric oxide modulates the NMDA receptor via a feedback mechanism and regulates the dynamic behavior of postsynaptic components. Results obtained by numerical analyses indicate that the biochemical system is stimulus-dependent and shows oscillations of calcium and other components within a limited range of concentration. Some of the parameters such as stimulus strength, extracellular calcium concentration, and rate of nitric oxide feedback are crucial for the dynamics of the components in the postsynaptic neuron." @default.
• W4387108229 created "2023-09-28" @default.
• W4387108229 creator A5015849619 @default.
• W4387108229 creator A5038366883 @default.
• W4387108229 creator A5072400587 @default.
• W4387108229 date "2023-12-01" @default.
• W4387108229 modified "2023-10-15" @default.
• W4387108229 title "Nitric oxide modulates NMDA receptor through a negative feedback mechanism and regulates the dynamical behavior of neuronal postsynaptic components" @default.
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