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- W4387115104 abstract "Abstract Hydrogen peroxide (H 2 O 2 ) functions as a second messenger to signal metabolic distress through highly compartmentalized production in mitochondria. The dynamics of reactive oxygen species (ROS) generation and diffusion between mitochondrial compartments and into the cytosol govern oxidative stress responses and pathology, though these processes remain poorly understood. Here, we couple the H 2 O 2 biosensor, HyPer7, with optogenetic stimulation of the ROS-generating protein KillerRed targeted into multiple mitochondrial microdomains. Single mitochondrial photogeneration of H 2 O 2 demonstrates the spatiotemporal dynamics of ROS diffusion and transient hyperfusion of mitochondria due to ROS. This transient hyperfusion phenotype required mitochondrial fusion but not fission machinery. Measurement of microdomain-specific H 2 O 2 diffusion kinetics reveals directionally selective diffusion through mitochondrial microdomains. All-optical generation and detection of physiologically-relevant concentrations of H 2 O 2 between mitochondrial compartments provide a map of mitochondrial H 2 O 2 diffusion dynamics in situ as a framework to understand the role of ROS in health and disease." @default.
- W4387115104 created "2023-09-29" @default.
- W4387115104 creator A5003517213 @default.
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- W4387115104 date "2023-09-27" @default.
- W4387115104 modified "2023-10-17" @default.
- W4387115104 title "All-optical spatiotemporal mapping of ROS dynamics across mitochondrial microdomains in situ" @default.
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