FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387117633> ?p ?o ?g. }

• W4387117633 abstract "Chronic metabolic changes relevant to human immunodeficiency virus type 1 (HIV-1) infection and in response to antiretroviral therapy (ART) remain undetermined. Moreover, links between metabolic dysfunction caused by HIV and immunological inflammation in long-term treated individuals have been poorly studied.Untargeted metabolomics and inflammatory cytokine levels were assessed in 47 HIV-infected individuals including 22 immunological responders (IRs) and 25 non-responders (INRs) before and after ART. The IRs and INRs were matched by age, gender, baseline viral load, and baseline CD4+T cell counts. Another 25 age-matched uninfected healthy individuals were also included as controls.Among the 770 plasma compounds detected in the current study, significant changes were identified in lipids, nucleotides, and biogenic amino acids between HIV-infected patients and healthy controls. Principal Component Analysis (PCA) and the Random Forest (RF) model suggested that levels of selected metabolites could differentiate HIV-infected patients clearly from healthy controls. However, the metabolite profiles identified in our patients were similar, and only three metabolites, maltotetraose, N, N-dimethyl-5-aminovalerate, and decadienedioic acid (C10:2-DC), were different between IRs and INRs following long-term ART. The pathway enrichment analysis results revealed that disturbances in pyrimidine metabolism, sphingolipid metabolism, and purine metabolism after HIV infection and these changes did not recover to normal levels in healthy controls even with suppressive ART. Correlation analysis of the metabolism-immune network indicated that interleukin (IL)-10, D-dimer, vascular cell adhesion molecule-1 (VCAM-1), intercellular cell adhesion molecule-1 (ICAM-1), and TNF-RII were positively correlated with most of the significantly changed lipid and amino acid metabolites but negatively correlated with metabolites in nucleotide metabolism.Significant changes in many metabolites were observed in HIV-infected individuals before and after ART regardless of their immunological recovery status. The disturbed metabolic profiles of lipids and nucleotides in HIV infection did not recover to normal levels even after long-term ART. These changes are correlated with modified cytokines and biomarkers of chronic non-AIDS events, warranting tryout of interventions other than ART." @default.
• W4387117633 created "2023-09-29" @default.
• W4387117633 creator A5001819052 @default.
• W4387117633 creator A5009696416 @default.
• W4387117633 creator A5016140099 @default.
• W4387117633 creator A5031998757 @default.
• W4387117633 creator A5036532057 @default.
• W4387117633 creator A5044185317 @default.
• W4387117633 creator A5044459845 @default.
• W4387117633 creator A5049692788 @default.
• W4387117633 creator A5050745421 @default.
• W4387117633 creator A5051817115 @default.
• W4387117633 creator A5057762207 @default.
• W4387117633 creator A5076357748 @default.
• W4387117633 date "2023-09-27" @default.
• W4387117633 modified "2023-10-15" @default.
• W4387117633 title "Altered plasma metabolites and inflammatory networks in HIV-1 infected patients with different immunological responses after long-term antiretroviral therapy" @default.
• W4387117633 cites W2032722583 @default.
• W4387117633 cites W2037619924 @default.
• W4387117633 cites W2058610272 @default.
• W4387117633 cites W2095199804 @default.
• W4387117633 cites W2096380205 @default.
• W4387117633 cites W2345060140 @default.
• W4387117633 cites W2412816857 @default.
• W4387117633 cites W2564682719 @default.
• W4387117633 cites W2776196691 @default.
• W4387117633 cites W2790526544 @default.
• W4387117633 cites W2804627297 @default.
• W4387117633 cites W2901309372 @default.
• W4387117633 cites W2932485707 @default.
• W4387117633 cites W2966651789 @default.
• W4387117633 cites W2975708155 @default.
• W4387117633 cites W2990797528 @default.
• W4387117633 cites W3028711203 @default.
• W4387117633 cites W3110399623 @default.
• W4387117633 cites W3181214794 @default.
• W4387117633 cites W3192920595 @default.
• W4387117633 cites W3193479513 @default.
• W4387117633 cites W4221107073 @default.
• W4387117633 cites W4224031304 @default.
• W4387117633 cites W4229366362 @default.
• W4387117633 cites W4283161425 @default.
• W4387117633 cites W4283773782 @default.
• W4387117633 cites W4291015035 @default.
• W4387117633 cites W4293093336 @default.
• W4387117633 cites W4293531246 @default.
• W4387117633 cites W4308687743 @default.
• W4387117633 cites W4311142663 @default.
• W4387117633 cites W4313250565 @default.
• W4387117633 cites W4319293970 @default.
• W4387117633 cites W4324307160 @default.
• W4387117633 cites W4362601901 @default.
• W4387117633 cites W4362704104 @default.
• W4387117633 cites W4376601423 @default.
• W4387117633 doi "https://doi.org/10.3389/fimmu.2023.1254155" @default.
• W4387117633 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37828979" @default.
• W4387117633 hasPublicationYear "2023" @default.
• W4387117633 type Work @default.
• W4387117633 citedByCount "0" @default.
• W4387117633 crossrefType "journal-article" @default.
• W4387117633 hasAuthorship W4387117633A5001819052 @default.
• W4387117633 hasAuthorship W4387117633A5009696416 @default.
• W4387117633 hasAuthorship W4387117633A5016140099 @default.
• W4387117633 hasAuthorship W4387117633A5031998757 @default.
• W4387117633 hasAuthorship W4387117633A5036532057 @default.
• W4387117633 hasAuthorship W4387117633A5044185317 @default.
• W4387117633 hasAuthorship W4387117633A5044459845 @default.
• W4387117633 hasAuthorship W4387117633A5049692788 @default.
• W4387117633 hasAuthorship W4387117633A5050745421 @default.
• W4387117633 hasAuthorship W4387117633A5051817115 @default.
• W4387117633 hasAuthorship W4387117633A5057762207 @default.
• W4387117633 hasAuthorship W4387117633A5076357748 @default.
• W4387117633 hasBestOaLocation W43871176331 @default.
• W4387117633 hasConcept C126322002 @default.
• W4387117633 hasConcept C134659918 @default.
• W4387117633 hasConcept C142462285 @default.
• W4387117633 hasConcept C1491633281 @default.
• W4387117633 hasConcept C181199279 @default.
• W4387117633 hasConcept C203014093 @default.
• W4387117633 hasConcept C2522874641 @default.
• W4387117633 hasConcept C2776476023 @default.
• W4387117633 hasConcept C2776914184 @default.
• W4387117633 hasConcept C2777477808 @default.
• W4387117633 hasConcept C2778690821 @default.
• W4387117633 hasConcept C55493867 @default.
• W4387117633 hasConcept C71924100 @default.
• W4387117633 hasConcept C85789140 @default.
• W4387117633 hasConcept C86803240 @default.
• W4387117633 hasConcept C8891405 @default.
• W4387117633 hasConceptScore W4387117633C126322002 @default.
• W4387117633 hasConceptScore W4387117633C134659918 @default.
• W4387117633 hasConceptScore W4387117633C142462285 @default.
• W4387117633 hasConceptScore W4387117633C1491633281 @default.
• W4387117633 hasConceptScore W4387117633C181199279 @default.
• W4387117633 hasConceptScore W4387117633C203014093 @default.
• W4387117633 hasConceptScore W4387117633C2522874641 @default.
• W4387117633 hasConceptScore W4387117633C2776476023 @default.
• W4387117633 hasConceptScore W4387117633C2776914184 @default.
• W4387117633 hasConceptScore W4387117633C2777477808 @default.
• W4387117633 hasConceptScore W4387117633C2778690821 @default.

• next