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- W4387118414 abstract "Introduction: Cervical Cancer is listed as the third commonest malignancy seen in women, worldwide. E-cadherin is a molecule with an important role in interaction of cell-cell and cell-extracellular matrix and its loss is important in tumor spread. This study was planned to evaluate the expression of E-Cadherin in precancerous and cancerous lesions of cervix. In this study 60 bi Methodology: opsies of cervical lesions were included. Cervical biopsies were taken in women with CIN II, CIN III, Well- differentiated squamous cell carcinoma, Moderately differentiated carcinoma, Poorly differentiated carcinoma, Undifferentiated carcinoma and Lymphoepithelioma. Immunohistochemical staining for E cadherin was done on all parafn blocks using monoclonal antibody. HPV DNA analysis was detected by PCR. Relevant personal and clinical data were documented. E– cadherin expression showed signicantly higher grade of expression in chronic Results: cervicitis as compared to premalignant and malignant lesions. Out of the 60 cases screened for HPV DNA by PCR, 26.6 % (10 cases) tested positive for HPV infection. Further investigation for HPV type 16/18 showed that 3 (18.7%) out of 16 cases tested for HR- HPV type 16 and 7(43.7%) for type 18. Conclusion: Expression of E-cadherin was observed to be inversely proportional to loss of cell differentiation. Loss of E-cadherin staining was closely related to grade of dysplasia. It can be used as a prognostic marker for cervical squamous premalignant and malignant lesions of cervix." @default.
- W4387118414 created "2023-09-29" @default.
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- W4387118414 date "2023-09-01" @default.
- W4387118414 modified "2023-10-18" @default.
- W4387118414 title "E-CADHERIN IN PRECANCEROUS AND CANCEROUS LESIONS OF CERVIX AND CORRELATION WITH HUMAN PAPILLOMA VIRUS" @default.
- W4387118414 doi "https://doi.org/10.36106/ijsr/7102994" @default.
- W4387118414 hasPublicationYear "2023" @default.
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